Q9D2R0

PR
Gene name
Aacs
Protein name
Acetoacetyl-CoA synthetase
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:78894
EC number
6.2.1.16: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D2R0

Entry ID Method Resolution Chain Position Source
AF-Q9D2R0-F1 Predicted AlphaFoldDB

47 variants for Q9D2R0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388794430 2 S>T No EVA
rs38516850 6 R>Q No EVA
rs3396213547 40 C>G No EVA
rs248327647 59 M>V No EVA
rs3388783469 77 Y>* No EVA
rs3388792735 91 P>L No EVA
rs36326951 107 R>W No EVA
rs13471307 112 D>Y No EVA
rs3388798079 113 R>I No EVA
rs3388765561 170 M>L No EVA
rs3388795049 194 D>N No EVA
rs3388777030 194 D>V No EVA
rs3388788529 201 P>Q No EVA
rs3395473692 202 K>P No EVA
rs3388792711 207 V>M No EVA
rs3388790015 210 V>F No EVA
rs3388783540 265 S>C No EVA
rs3396206451 292 G>C No EVA
rs3396116354 294 T>R No EVA
rs3388779494 307 T>S No EVA
rs36769124 322 T>I No EVA
rs3412907535 363 P>H No EVA
rs3396142511 365 V>A No EVA
rs3396166264 365 V>M No EVA
rs3396206495 367 W>G No EVA
rs3388791738 396 V>M No EVA
rs864281472 397 E>G No EVA
rs3388779430 401 L>F No EVA
rs3388795609 406 T>M No EVA
rs241730457 425 C>Y No EVA
rs3388765551 444 C>* No EVA
rs3388765550 471 W>R No EVA
rs3388790018 476 K>N No EVA
rs3388779469 482 S>N No EVA
rs3388765560 490 P>S No EVA
rs253972771 497 H>Y No EVA
rs3388791652 517 G>D No EVA
rs3388777032 530 K>N No EVA
rs3388791655 584 V>I No EVA
rs3395473782 593 H>R No EVA
rs3396200428 597 P>A No EVA
rs3388801714 608 R>G No EVA
rs249521856 631 N>S No EVA
rs3388783453 633 K>R No EVA
rs108635678 637 V>A No EVA
rs3396077575 670 Q>L No EVA
rs3396142493 673 F>S No EVA

No associated diseases with Q9D2R0

6 regional properties for Q9D2R0

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 478 - 713 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1290 - 1533 IPR003439-2
domain AAA+ ATPase domain 506 - 691 IPR003593-1
domain AAA+ ATPase domain 1325 - 1512 IPR003593-2
domain ABC-2 type transporter, transmembrane domain 33 - 416 IPR013525
conserved_site ABC transporter-like, conserved site 615 - 629 IPR017871

Functions

Description
EC Number 6.2.1.16 Acid--thiol ligases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
acetoacetate-CoA ligase activity Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
butyrate-CoA ligase activity Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.

10 GO annotations of biological process

Name Definition
cellular response to glucose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
positive regulation of insulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
response to nutrient Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
response to oleic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus.
response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
response to organonitrogen compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic Homo sapiens (Human) PR
Q68CK6 ACSM2B Acyl-coenzyme A synthetase ACSM2B, mitochondrial Homo sapiens (Human) PR
Q08AH3 ACSM2A Acyl-coenzyme A synthetase ACSM2A, mitochondrial Homo sapiens (Human) PR
Q9QXG4 Acss2 Acetyl-coenzyme A synthetase, cytoplasmic Mus musculus (Mouse) PR
Q8K0L3 Acsm2 Acyl-coenzyme A synthetase ACSM2, mitochondrial Mus musculus (Mouse) PR
O70490 Acsm2 Acyl-coenzyme A synthetase ACSM2, mitochondrial Rattus norvegicus (Rat) PR
Q9JMI1 Aacs Acetoacetyl-CoA synthetase Rattus norvegicus (Rat) PR
Q84P17 AAE18 Probable acyl-activating enzyme 18, peroxisomal Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSKLARLERE EIMECQVMWE PDSKKDTQMD RFRAAVGTAC GLALGNYNDL YHWSVRSYMD
70 80 90 100 110 120
FWAEFWKFSG IVYSRMYDEV VDTSKGIADV PEWFRGSRLN YAENLLRHKE NDRVALYVAR
130 140 150 160 170 180
EGREEIVKVT FEELRQQVAL FAAAMRKMGV KKGDRVVGYL PNSAHAVEAM LAAASIGAIW
190 200 210 220 230 240
SSTSPDFGVN GVLDRFSQIQ PKLIFSVEAV VYNGKEHGHL EKLQRVVKGL PDLQRVVLIP
250 260 270 280 290 300
YVLPREKIDI SKIPNSVFLD DFLASGTGAQ APQLEFEQLP FSHPLFIMFS SGTTGAPKCM
310 320 330 340 350 360
VHSAGGTLIQ HLKEHMLHGN MTSSDILLYY TTVGWMMWNW MVSALATGAS LVLYDGSPLV
370 380 390 400 410 420
PTPNVLWDLV DRIGITILGT GAKWLSVLEE KDMKPVETHN LHTLHTILST GSPLKAQSYE
430 440 450 460 470 480
YVYRCIKSSV LLGSISGGTD IISCFMGQNS SIPVYKGEIQ ARNLGMAVEA WDEEGKAVWG
490 500 510 520 530 540
ASGELVCTKP IPCQPTHFWN DENGSKYRKA YFSKFPGVWA HGDYCRINPK TGGIIMLGRS
550 560 570 580 590 600
DGTLNPNGVR FGSSEIYNIV EAFDEVEDSL CVPQYNRDGE ERVVLFLKMA SGHTFQPDLV
610 620 630 640 650 660
KRIRDAIRLG LSARHVPSLI LETRGIPYTL NGKKVEVAVK QVMAGRTVEH RGAFSNPETL
670
DLYRDIPELQ DF