AiPD: Autoinhibited Protein Database

Gene name	Acsm2
Protein name	Acyl-coenzyme A synthetase ACSM2, mitochondrial
Names	Acyl-CoA synthetase medium-chain family member 2, Benzoate--CoA ligase, Butyrate--CoA ligase 2, Butyryl-coenzyme A synthetase 2, Middle-chain acyl-CoA synthetase 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:233799
EC number	6.2.1.2: Acid--thiol ligases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

183-267 (Predicted disordered autoinhibitory region) PR

183-267 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8K0L3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs228867113	21	R>C	No	EVA
rs3388941652	27	I>N	No	EVA
rs3388939240	34	Q>E	No	EVA
rs243000849	57	V>I	No	EVA
rs231762316	84	R>Q	No	EVA
rs3388899046	137	T>S	No	EVA
rs3388939694	167	V>L	No	EVA
rs3388945798	185	E>G	No	EVA
rs3388915023	189	E>D	No	EVA
rs32561385	213	R>Q	No	EVA
rs3388944974	233	H>L	No	EVA
rs3398553324	248	S>R	No	EVA
rs227696573	268	M>L	No	EVA
rs3388899061	276	E>D	No	EVA
rs213845667	288	L>V	No	EVA
rs3398481993	289	L>*	No	EVA
rs32557893	303	S>R	No	EVA
rs257616574	308	T>S	No	EVA
rs227884249	308	T>S	No	EVA
rs219602722	315	I>V	No	EVA
rs221980725	361	I>F	No	EVA
rs221723292	370	I>T	No	EVA
rs3388945121	371	C>Y	No	EVA
rs32560048	389	A>P	No	EVA
rs32562165	418	I>T	No	EVA
rs219641773	445	M>T	No	EVA
rs228397711	448	R>Q	No	EVA
rs3388941322	466	I>F	No	EVA
rs3388936350	477	S>P	No	EVA
rs3388939302	505	V>G	No	EVA
rs3388945134	543	R>G	No	EVA
rs3388941716	551	L>P	No	EVA
rs3388939262	558	K>N	No	EVA
rs3388945825	566	A>S	No	EVA
rs3388941715	568	E>D	No	EVA
rs579137449	574	R>Q	No	EVA
rs582379148	576	A>Y	No	EVA

Type	Name	Position	InterPro Accession
domain	AMP-dependent synthetase/ligase domain	62 - 469	IPR000873
conserved_site	AMP-binding, conserved site	218 - 229	IPR020845
domain	AMP-binding enzyme, C-terminal domain	478 - 558	IPR025110

		Description
EC Number	6.2.1.2	Acid--thiol ligases
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
benzoate-CoA ligase activity	Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.
butyrate-CoA ligase activity	Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.
decanoate-CoA ligase activity	Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA.
fatty acid ligase activity	Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP.
fatty-acyl-CoA synthase activity	Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
metal ion binding	Binding to a metal ion.

Name	Definition
acyl-CoA metabolic process	The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NR19	ACSS2	Acetyl-coenzyme A synthetase, cytoplasmic	Homo sapiens (Human)	PR
Q08AH3	ACSM2A	Acyl-coenzyme A synthetase ACSM2A, mitochondrial	Homo sapiens (Human)	PR
Q68CK6	ACSM2B	Acyl-coenzyme A synthetase ACSM2B, mitochondrial	Homo sapiens (Human)	PR
Q9QXG4	Acss2	Acetyl-coenzyme A synthetase, cytoplasmic	Mus musculus (Mouse)	PR
Q9D2R0	Aacs	Acetoacetyl-CoA synthetase	Mus musculus (Mouse)	PR
Q9JMI1	Aacs	Acetoacetyl-CoA synthetase	Rattus norvegicus (Rat)	PR
O70490	Acsm2	Acyl-coenzyme A synthetase ACSM2, mitochondrial	Rattus norvegicus (Rat)	PR
Q84P17	AAE18	Probable acyl-activating enzyme 18, peroxisomal	Arabidopsis thaliana (Mouse-ear cress)	PR