Q9LUQ5

PR
Gene name
UBC25 (At3g15355, MJK13.1)
Protein name
Probable ubiquitin-conjugating enzyme E2 25
Names
E2 ubiquitin-conjugating enzyme 25, Ubiquitin carrier protein 25
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G15355
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

121-206 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LUQ5

Entry ID Method Resolution Chain Position Source
AF-Q9LUQ5-F1 Predicted AlphaFoldDB

35 variants for Q9LUQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_5183879_A_G 8 I>V No 1000Genomes
tmp_3_5184456_C_T 28 P>S No 1000Genomes
tmp_3_5184469_A_C 32 D>A No 1000Genomes
tmp_3_5184544_C_G 57 A>G No 1000Genomes
tmp_3_5184563_G_A 63 M>I No 1000Genomes
tmp_3_5184591_G_A 73 E>K No 1000Genomes
tmp_3_5184753_G_A 97 D>N No 1000Genomes
ENSVATH05836214 99 E>D No 1000Genomes
ENSVATH05836215 152 D>E No 1000Genomes
ENSVATH05836216 184 F>V No 1000Genomes
tmp_3_5185015_T_A 184 F>Y No 1000Genomes
ENSVATH10693298 192 V>A No 1000Genomes
tmp_3_5185048_C_A 195 P>Q No 1000Genomes
ENSVATH10693299 220 A>V No 1000Genomes
tmp_3_5185141_C_A 226 A>D No 1000Genomes
ENSVATH13923303 256 A>T No 1000Genomes
ENSVATH05836219 281 P>L No 1000Genomes
tmp_3_5185308_C_T 282 P>S No 1000Genomes
tmp_3_5185369_A_G 302 Y>C No 1000Genomes
tmp_3_5185578_T_G 343 I>M No 1000Genomes
tmp_3_5185714_G_A 361 M>I No 1000Genomes
ENSVATH13923315 399 H>Y No 1000Genomes
ENSVATH05836226 478 A>T No 1000Genomes
tmp_3_5186172_C_T 483 T>I No 1000Genomes
tmp_3_5186223_A_G 500 K>R No 1000Genomes
ENSVATH05836229 512 S>G No 1000Genomes
ENSVATH02147349 519 K>E No 1000Genomes
tmp_3_5186445_G_T 536 G>W No 1000Genomes
ENSVATH10693355 537 A>P No 1000Genomes
ENSVATH10693355 537 A>T No 1000Genomes
ENSVATH00324665 538 P>L No 1000Genomes
tmp_3_5186456_T_G 539 D>E No 1000Genomes
tmp_3_5186500_C_T 554 T>I No 1000Genomes
ENSVATH05836231 585 P>A No 1000Genomes
tmp_3_5186631_A_G 598 R>G No 1000Genomes

No associated diseases with Q9LUQ5

1 regional properties for Q9LUQ5

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 332 - 492 IPR000608

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

3 GO annotations of biological process

Name Definition
postreplication repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.
protein K63-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9C0C9 UBE2O (E3-independent) E2 ubiquitin-conjugating enzyme Homo sapiens (Human) PR
Q6ZPJ3 Ube2o (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O Mus musculus (Mouse) PR
Q11076 ubc-17 Probable ubiquitin-conjugating enzyme protein 17 Caenorhabditis elegans PR
F4HPP7 UBC39 Putative ubiquitin-conjugating enzyme E2 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY87 UBC26 Probable ubiquitin-conjugating enzyme E2 26 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEPNVVEIAT PPAASCSRIR TPTKAETPEV IDVEEYDLQN GGVPNGNNVD YKNKGKAIDF
70 80 90 100 110 120
DSMSYGDYGE EDEYAVGSPG DDYGYPESSP LSNSLLDPES LIYEDDENYS EQYDFEMEAE
130 140 150 160 170 180
PDNYSMYQDL FDGKDIPTGV EVSMDWFPNS ADKESASSSK SSHANNGNNS SKKATKASGI
190 200 210 220 230 240
HSQFSSDMET PVAQPWNALP HKAEGVIPNS AYALPQNSKA FQPPYAVHYS ALKTAFSNYL
250 260 270 280 290 300
QPQTPDTVLG EAPAPAAGSS GLLPPNTPGF KSNAARFKEE PPILPPDDSR VKRNMEDYLG
310 320 330 340 350 360
LYLFFKRFDI VEDFSDHHYA SKGTTSKQHS KDWAKRIQDE WRILEKDLPE MIFVRAYESR
370 380 390 400 410 420
MDLLRAVIIG AQGTPYHDGL FFFDIFFPDT YPSTPPIVHY HSGGLRINPN LYNCGKVCLS
430 440 450 460 470 480
LLGTWSGNQR EKWIPNTSTM LQVLVSIQGL ILNQKPYFNE PGYERSAGSA HGESTSKAYS
490 500 510 520 530 540
ENTFILSLKT MVYTMRRPPK YFEDFAYGHF FSCAHDVLKA CNAYRNGATP GYLVKGAPDV
550 560 570 580 590 600
EENSAGMSSL KFRTDVATFV ETVLLKEFIL LGVLGLEPEE EEKTPETIIV AESSKCTRSR
SKRDRVSSS