Q6ZPJ3
PR
Gene name |
Ube2o (Kiaa1734) |
Protein name |
(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O |
Names |
E2/E3 hybrid ubiquitin-protein ligase UBE2O, Ubiquitin carrier protein O, Ubiquitin-conjugating enzyme E2 O, Ubiquitin-conjugating enzyme E2 of 230 kDa, Ubiquitin-conjugating enzyme E2-230K, Ubiquitin-protein ligase O |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:217342 |
EC number |
2.3.2.24: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6ZPJ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6ZPJ3-F1 | Predicted | AlphaFoldDB |
53 variants for Q6ZPJ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389235312 | 160 | T>K | No | EVA | |
| rs3389235283 | 183 | N>K | No | EVA | |
| rs3389189690 | 187 | L>I | No | EVA | |
| rs3402595537 | 280 | V>A | No | EVA | |
| rs3389214753 | 323 | I>F | No | EVA | |
| rs3389221120 | 337 | F>L | No | EVA | |
| rs3389182151 | 340 | A>G | No | EVA | |
| rs3389218403 | 347 | R>S | No | EVA | |
| rs3389189664 | 395 | C>Y | No | EVA | |
| rs3389207101 | 407 | M>I | No | EVA | |
| rs3389155493 | 412 | K>* | No | EVA | |
| rs3389218359 | 464 | G>R | No | EVA | |
| rs3389222688 | 465 | D>Y | No | EVA | |
| rs3389221084 | 498 | S>Y | No | EVA | |
| rs3389218434 | 500 | Q>H | No | EVA | |
| rs3389182084 | 539 | V>L | No | EVA | |
| rs3389182084 | 539 | V>M | No | EVA | |
| rs3389235273 | 570 | P>H | No | EVA | |
| rs3389194447 | 585 | V>E | No | EVA | |
| rs3389222708 | 655 | I>F | No | EVA | |
| rs3389222732 | 672 | S>* | No | EVA | |
| rs3389214679 | 676 | V>A | No | EVA | |
| rs3389222719 | 700 | Q>* | No | EVA | |
| rs3389220063 | 736 | W>* | No | EVA | |
| rs3389155506 | 750 | I>L | No | EVA | |
| rs3389215553 | 805 | P>S | No | EVA | |
| rs3402850265 | 814 | A>G | No | EVA | |
| rs3402595532 | 823 | N>K | No | EVA | |
| rs3389215579 | 843 | K>N | No | EVA | |
| rs3389214693 | 843 | K>R | No | EVA | |
| rs3389214693 | 843 | K>T | No | EVA | |
| rs3389219992 | 892 | Q>* | No | EVA | |
| rs3389222687 | 909 | Q>H | No | EVA | |
| rs3389218345 | 911 | G>A | No | EVA | |
| rs3389219609 | 931 | F>L | No | EVA | |
| rs3402432683 | 962 | L>Q | No | EVA | |
| rs3402432701 | 965 | S>P | No | EVA | |
| rs3402941368 | 966 | L>M | No | EVA | |
| rs3389235254 | 1052 | W>* | No | EVA | |
| rs3389219602 | 1057 | S>T | No | EVA | |
| rs13468159 | 1105 | V>M | No | EVA | |
| rs3402961789 | 1117 | P>H | No | EVA | |
| rs3402852035 | 1120 | F>V | No | EVA | |
| rs3389182091 | 1152 | A>V | No | EVA | |
| rs27002268 | 1160 | L>P | No | EVA | |
| rs3389219642 | 1162 | D>N | No | EVA | |
| rs3402735978 | 1188 | A>G | No | EVA | |
| rs3402941403 | 1188 | A>T | No | EVA | |
| rs3389218371 | 1226 | P>A | No | EVA | |
| rs3389228406 | 1229 | R>G | No | EVA | |
| rs3389207070 | 1264 | S>* | No | EVA | |
| rs3389215564 | 1275 | A>V | No | EVA | |
| rs3389231328 | 1289 | K>Y | No | EVA |
No associated diseases with Q6ZPJ3
1 regional properties for Q6ZPJ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ubiquitin-conjugating enzyme E2 | 950 - 1110 | IPR000608 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.24 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cysteine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of BMP signaling pathway | Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. |
| protein K63-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. |
| protein monoubiquitination | Addition of a single ubiquitin group to a protein. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9C0C9 | UBE2O | (E3-independent) E2 ubiquitin-conjugating enzyme | Homo sapiens (Human) | PR |
| Q11076 | ubc-17 | Probable ubiquitin-conjugating enzyme protein 17 | Caenorhabditis elegans | PR |
| F4HPP7 | UBC39 | Putative ubiquitin-conjugating enzyme E2 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY87 | UBC26 | Probable ubiquitin-conjugating enzyme E2 26 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUQ5 | UBC25 | Probable ubiquitin-conjugating enzyme E2 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADPAAPAPA | QAQAAAAPTP | AAAPAAAAPP | PAPATDSASG | PSSDSGPEAG | SQRLLFSHDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VSGRYRGSVH | FGLVRLIHGE | DSDSEGDDDG | RGSSGCSEAG | GAGHEEGRAS | PLRRGYVRVQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WYPEGVKQHV | KETKLKLEDR | SVVPRDVVRH | MRSTDSQCGT | VIDVNIDCAV | KLIGTNCIIY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVNSKDLQHI | WPFMYGDYIA | YDCWLGKVYD | LKNQIILKLS | NGARCSMNTE | DGAKLYDVCP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HVSDSGLFFD | DSYGFYPGQV | LIGPAKIFSS | VQWLSGVKPV | LSTKSKFRVV | VEEVQVVELK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VTWITKSFCP | GGTDSVSPPP | SIITQENLGR | VKRLGCFDHA | QRQLGERCLY | VFPAKVEPAK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IAWECPEKNC | AQGEGSMAKK | VKRLLKKQVV | RIMSCTPDTQ | CPRDHSMEDP | DKKGEARAGS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EIGSASPEEQ | PDGSASPVEM | QDEGSEELQE | TCEPLPPFLL | KEGGDDGLHS | AEQDADDEAA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DDTDDTSSVT | SSASSTTSSQ | SGSGTGRKKS | IPLSIKNLKR | KHKRKKNKVT | RDFKPGDRVA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VEVVTTMTSA | DVMWQDGSVE | CNIRSNDLFP | VHHLDNNEFC | PGDFVVDKRV | QSCPDPAVYG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VVQSGDHVGR | TCMVKWFKLR | PSGDDVELIG | EEEDVSVYDI | ADHPDFRFRT | TDIVIRIGNT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EDGALPKEDE | PSVGQVARVD | VSSKVEVVWA | DNSKTIILPQ | HLYNIESEIE | ESDYDSVEGS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SSGASSDEWE | DDSDSWETDN | GLVDDEHPKI | EELAAILPAE | QPTAPEEDKG | VVISEEAATA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AIQGAVAMAA | PVAGLMEKAG | KDGPPKSFRE | LKEAIKILES | LKNMTVEQLL | TGSPTSPTVE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PEKPTREKKF | LDDIKKLQEN | LKKTLDNVAI | AEEEKMEAVP | DTERKEEKPE | VQSPVKAEWP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SETPVLCQQC | GGRPGVTFTS | AKGEVFSVLE | FAPSNHSFKK | IEFQPPEAKK | FFSTVRKEMA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LLATSLPDGI | MVKTFEDRMD | LFSALIKGPT | RTPYEDGLYL | FDIQLPNIYP | AVPPHFCYLS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| QCSGRLNPNL | YDNGKVCVSL | LGTWIGKGTE | RWTSKSSLLQ | VLISIQGLIL | VNEPYYNEAG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| FDSDRGLQEG | YENSRCYNEM | ALIRVVQSMT | QLVRRPPEVF | EQEIRQHFSV | GGWRLVNRIE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SWLETHAMQE | RAQVMPNGAL | KDSSSLEPMA | AAELSDSGRE | EPEDVGMAPG | EASQGSDSEG |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| GAQGPASASR | DHTEQTETAP | DASAPPSVRP | KRRRKSYRSF | LPEKSGYPDI | GFPLFPLSKG |
| 1270 | 1280 | ||||
| FIKSIRGVLT | QFRAALLEAG | MPESTEDK |