Q11076
Gene name |
ubc-17 (B0403.2) |
Protein name |
Probable ubiquitin-conjugating enzyme protein 17 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_B0403.2 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q11076
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q11076-F1 | Predicted | AlphaFoldDB |
No variants for Q11076
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q11076 | |||||
No associated diseases with Q11076
1 regional properties for Q11076
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ubiquitin-conjugating enzyme E2 | 402 - 568 | IPR000608 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| ligase activity | Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9C0C9 | UBE2O | (E3-independent) E2 ubiquitin-conjugating enzyme | Homo sapiens (Human) | PR |
| Q6ZPJ3 | Ube2o | (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O | Mus musculus (Mouse) | PR |
| Q8GY87 | UBC26 | Probable ubiquitin-conjugating enzyme E2 26 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUQ5 | UBC25 | Probable ubiquitin-conjugating enzyme E2 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HPP7 | UBC39 | Putative ubiquitin-conjugating enzyme E2 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSQASQRSS | STSAVAQKTR | ERRKSKSRRR | CWFGCLWLSS | RVSLIRSSSR | FSRSPEPDES |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTAIDKVMSI | INEKPLKMAH | ILKTARFVND | VSFSERKQFV | ECGVIHHLLE | LIGETAISDF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SASSRSADEQ | KRRARRNSSA | SLSHKGTGYG | TGSTRSRWDI | ERTVEEKLIR | EEHLTWLLSI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNSFMLGWPT | TDNLKTKPEE | LVHMTEIAIK | LIADSSVLSI | LEYNLRNDSF | FDVSEHIEIY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QALLETAASM | AATPGLVPFL | VRPYTSSAKS | IAKELIPRFK | ENILSIQARW | GGTLEETNFR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MAEFTAKVTL | LSDYVINAAR | AYEQTLPPEQ | RIQTATHRRP | SHSGLHSKMQ | GPKDDETIYK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NKMQELQLQT | AKFIGDFGKL | CVPYVFRKEA | KNINPFSPHL | RDRTKRIAKE | LASIANALPL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NASNSIYVCY | DEGRVDIIKV | LISGPDDTPY | ANGLFEFDIF | FPTGYPFSPP | KCAFLTTGSG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NVRFNPNLYN | DGKICLSILG | TWEGRPEEKW | NPYCSLMQVL | VSIQGLIFVK | DPYFNEPGFE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RYQGTDRGDE | YSRKYNLQIE | HATLNYAIRE | QLKKPSEHFK | EVIEKHLWLK | REAILKQAQA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WIDNVSNDFG | DDKMSKRKDV | FAFETGFNPA | TQERVIHNLI | QELQAMQSPF | AKEEAEESER |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LKREQSEKEE | KQKKEAAALA | EIEREKRELE | LDFQRRRSSV | LATHVAVIRT | QPTGDYSVPS |
| VNEPSTSS |