F4HPP7

PR
Gene name
UBC39 (At1g53023, F14G24.31, F8L10)
Protein name
Putative ubiquitin-conjugating enzyme E2 39
Names
E2 ubiquitin-conjugating enzyme 39, Ubiquitin carrier protein 39
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G53023
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4HPP7

Entry ID Method Resolution Chain Position Source
AF-F4HPP7-F1 Predicted AlphaFoldDB

46 variants for F4HPP7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04949891 5 K>E No 1000Genomes
tmp_1_19755532_T_C 11 R>G No 1000Genomes
ENSVATH04949881 16 E>K No 1000Genomes
tmp_1_19755503_G_C 20 D>E No 1000Genomes
tmp_1_19755421_G_A 48 H>Y No 1000Genomes
ENSVATH01361619 55 P>Q No 1000Genomes
ENSVATH13546825 55 P>S No 1000Genomes
ENSVATH13546814 60 K>N No 1000Genomes
ENSVATH04949875 71 K>Q No 1000Genomes
ENSVATH13546812 73 L>F No 1000Genomes
ENSVATH14303489 81 A>V No 1000Genomes
ENSVATH01361616 88 L>I No 1000Genomes
tmp_1_19755096_A_G 93 I>T No 1000Genomes
ENSVATH04949874 102 H>Y No 1000Genomes
ENSVATH13546811 108 F>Y No 1000Genomes
ENSVATH14303487 127 S>W No 1000Genomes
ENSVATH00095357 152 G>R No 1000Genomes
ENSVATH00095355 183 Y>F No 1000Genomes
ENSVATH13546810 192 M>T No 1000Genomes
tmp_1_19754709_C_T 193 G>R No 1000Genomes
tmp_1_19754705_G_A 194 T>I No 1000Genomes
ENSVATH04949868 201 S>Y No 1000Genomes
ENSVATH04949867 208 V>I No 1000Genomes
ENSVATH01361615 214 K>R No 1000Genomes
ENSVATH13546809 216 M>K No 1000Genomes
tmp_1_19754510_CA_TA,C 219 E>K No 1000Genomes
ENSVATH01361612 223 R>C No 1000Genomes
ENSVATH13546807 223 R>H No 1000Genomes
ENSVATH04949861 226 F>V No 1000Genomes
tmp_1_19754408_C_T 253 G>R No 1000Genomes
tmp_1_19754396_G_C 257 Q>E No 1000Genomes
tmp_1_19754393_T_G 258 T>P No 1000Genomes
tmp_1_19754389_C_G 259 R>T No 1000Genomes
tmp_1_19754387_G_A 260 Q>* No 1000Genomes
ENSVATH01361610 271 T>A No 1000Genomes
tmp_1_19754350_C_A 272 S>I No 1000Genomes
ENSVATH04949859 273 F>S No 1000Genomes
ENSVATH13546804 281 F>L No 1000Genomes
ENSVATH13546803 287 I>K No 1000Genomes
ENSVATH04949856 289 E>D No 1000Genomes
ENSVATH04949854 303 C>F No 1000Genomes
ENSVATH04949853 304 F>Y No 1000Genomes
tmp_1_19754245_CAAA_AAAA,CAA,CA,C 307 C>F No 1000Genomes
ENSVATH01361609 309 L>P No 1000Genomes
ENSVATH13546763 315 S>N No 1000Genomes
ENSVATH14303452 316 V>L No 1000Genomes

No associated diseases with F4HPP7

1 regional properties for F4HPP7

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 57 - 217 IPR000608

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9C0C9 UBE2O (E3-independent) E2 ubiquitin-conjugating enzyme Homo sapiens (Human) PR
Q6ZPJ3 Ube2o (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O Mus musculus (Mouse) PR
Q11076 ubc-17 Probable ubiquitin-conjugating enzyme protein 17 Caenorhabditis elegans PR
Q8GY87 UBC26 Probable ubiquitin-conjugating enzyme E2 26 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUQ5 UBC25 Probable ubiquitin-conjugating enzyme E2 25 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVEIKDSSNV RKLKEEFLRD FKRFDTVEDF SDHHYAAEGS PAKLSLWHLK FKGRPKNWVK
70 80 90 100 110 120
DIQKEWKILD KNLPETIFVR ACESRIDLLR AVIIGAEGTP YHDGLFFFDI QFPDTYPSVP
130 140 150 160 170 180
PKVHYHSGGL RINPNLYKCG KVCLSLISTW TGKKREKWLP KESTMLQLLV SIQALILNEK
190 200 210 220 230 240
PYYNEPGYEK SMGTPLGESY SKDYSENVFV FSLKTMHFEE FVRSHFFVRS HDIVKACNAY
250 260 270 280 290 300
KDGAPVGSID KGGVKKQTRQ RGSLKFRINV TSFMKTVVDE FVNLGAIREA NHRGEPNPTL
310
FSCFFFCYLE LIICSV