Q8GY87
PR
Gene name |
UBC26 (At1g53025, F8L10.11, F8L10.22) |
Protein name |
Probable ubiquitin-conjugating enzyme E2 26 |
Names |
E2 ubiquitin-conjugating enzyme 26, Ubiquitin carrier protein 26 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G53025 |
EC number |
2.3.2.23: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GY87
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GY87-F1 | Predicted | AlphaFoldDB |
66 variants for Q8GY87
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04949945 | 5 | V>L | No | 1000Genomes | |
| ENSVATH00095379 | 22 | K>R | No | 1000Genomes | |
| ENSVATH00095377 | 28 | P>S | No | 1000Genomes | |
| ENSVATH00095376 | 35 | S>R | No | 1000Genomes | |
| ENSVATH04949940 | 48 | N>T | No | 1000Genomes | |
| ENSVATH04949939 | 49 | V>I | No | 1000Genomes | |
| ENSVATH04949938 | 64 | F>L | No | 1000Genomes | |
| ENSVATH13546991 | 74 | H>P | No | 1000Genomes | |
| ENSVATH13546990 | 76 | S>P | No | 1000Genomes | |
| ENSVATH13546989 | 78 | L>P | No | 1000Genomes | |
| ENSVATH04949936 | 82 | E>D | No | 1000Genomes | |
| tmp_1_19758829_C_G | 82 | E>Q | No | 1000Genomes | |
| ENSVATH13546986 | 89 | G>S | No | 1000Genomes | |
| ENSVATH13546985 | 91 | K>N | No | 1000Genomes | |
| ENSVATH13546974 | 93 | I>N | No | 1000Genomes | |
| tmp_1_19758786_C_T | 96 | S>N | No | 1000Genomes | |
| tmp_1_19758738_T_C | 112 | Q>R | No | 1000Genomes | |
| tmp_1_19758729_A_T | 115 | L>Q | No | 1000Genomes | |
| ENSVATH00095375 | 119 | D>N | Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Flowering time was scored as the number of days for the bolt to reach 5cm [20-22c and natural light from the middle of october 2002 till march 2003] [EnsemblGenome] | No | 1000Genomes |
| ENSVATH00095374 | 136 | S>C | No | 1000Genomes | |
| ENSVATH00095374 | 136 | S>G | No | 1000Genomes | |
| tmp_1_19758664_T_C | 137 | K>E | No | 1000Genomes | |
| ENSVATH01361662 | 152 | M>T | No | 1000Genomes | |
| ENSVATH00095372 | 155 | Y>C | No | 1000Genomes | |
| tmp_1_19758606_C_T | 156 | G>E | No | 1000Genomes | |
| ENSVATH01361660 | 162 | T>K | No | 1000Genomes | |
| ENSVATH04949935 | 165 | V>F | No | 1000Genomes | |
| ENSVATH00095370 | 188 | A>S | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_1_19758510_G_A | 188 | A>V | No | 1000Genomes | |
| ENSVATH01361658 | 191 | P>R | No | 1000Genomes | |
| ENSVATH01361657 | 193 | T>I | No | 1000Genomes | |
| tmp_1_19758487_C_T | 196 | V>I | No | 1000Genomes | |
| ENSVATH13546972 | 201 | N>H | No | 1000Genomes | |
| tmp_1_19758452_A_T | 207 | F>L | No | 1000Genomes | |
| ENSVATH00095369 | 217 | H>R | No | 1000Genomes | |
| ENSVATH13546970 | 220 | A>V | No | 1000Genomes | |
| ENSVATH13546969 | 225 | S>T | No | 1000Genomes | |
| ENSVATH13546966 | 252 | D>Y | No | 1000Genomes | |
| ENSVATH04949929 | 273 | V>G | No | 1000Genomes | |
| tmp_1_19758149_C_T | 276 | V>I | No | 1000Genomes | |
| tmp_1_19758143_C_A | 278 | A>S | No | 1000Genomes | |
| tmp_1_19757941_A_T | 321 | F>Y | No | 1000Genomes | |
| tmp_1_19757749_C_T | 356 | V>I | No | 1000Genomes | |
| ENSVATH01361655 | 375 | N>K | No | 1000Genomes | |
| ENSVATH13546921 | 393 | E>G | No | 1000Genomes | |
| tmp_1_19757625_A_T | 397 | F>Y | No | 1000Genomes | |
| tmp_1_19757611_A_T | 402 | Y>N | No | 1000Genomes | |
| tmp_1_19757601_C_A | 405 | S>I | No | 1000Genomes | |
| tmp_1_19757598_G_A | 406 | A>V | No | 1000Genomes | |
| ENSVATH13546920 | 417 | V>I | No | 1000Genomes | |
| tmp_1_19757538_G_A | 426 | S>L | No | 1000Genomes | |
| ENSVATH13546919 | 434 | I>M | No | 1000Genomes | |
| ENSVATH13546918 | 436 | R>K | No | 1000Genomes | |
| ENSVATH04949925 | 439 | Q>E | No | 1000Genomes | |
| ENSVATH04949925 | 439 | Q>K | No | 1000Genomes | |
| ENSVATH01361649 | 482 | E>Q | No | 1000Genomes | |
| ENSVATH01361648 | 484 | R>S | No | 1000Genomes | |
| ENSVATH13546912 | 494 | D>G | No | 1000Genomes | |
| ENSVATH01361647 | 502 | V>L | No | 1000Genomes | |
| ENSVATH13546911 | 515 | A>V | No | 1000Genomes | |
| ENSVATH01361645 | 519 | E>K | No | 1000Genomes | |
| ENSVATH00095365 | 522 | M>V | Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| ENSVATH13546908 | 532 | K>N | No | 1000Genomes | |
| ENSVATH13546907 | 534 | K>R | No | 1000Genomes | |
| ENSVATH04949919 | 536 | R>L | No | 1000Genomes | |
| ENSVATH04949918 | 542 | S>L | No | 1000Genomes |
No associated diseases with Q8GY87
1 regional properties for Q8GY87
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ubiquitin-conjugating enzyme E2 | 271 - 431 | IPR000608 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.23 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| postreplication repair | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. |
| protein K63-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9C0C9 | UBE2O | (E3-independent) E2 ubiquitin-conjugating enzyme | Homo sapiens (Human) | PR |
| Q6ZPJ3 | Ube2o | (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O | Mus musculus (Mouse) | PR |
| Q11076 | ubc-17 | Probable ubiquitin-conjugating enzyme protein 17 | Caenorhabditis elegans | PR |
| F4HPP7 | UBC39 | Putative ubiquitin-conjugating enzyme E2 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUQ5 | UBC25 | Probable ubiquitin-conjugating enzyme E2 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPDVVEIPP | PPLIASGSRT | RKPRKAVPEV | IDVESYEFRN | VGVVKDNNVV | DKKNKGKAIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VDSFSFNNVQ | SHHHGSSLLN | LETFQDYYGH | KNIPFSEFAN | QPIDVDDYSM | YQDVLDPKDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PAGAEVTVPW | GLNSSSKGTA | KSSISIMRSQ | SMKGYGTVSL | ATTNVPQLWD | YTLPQQNQAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YSSVSFSAVQ | PQTPDVVMVT | NPTPNPFSYD | ASASSSHPIA | AEPISSVQDS | SNARKLKEEF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRDFKRFDTV | EDFSDHHYAS | KGKSSKQHSK | NWVKKVQADW | KILENDLPEA | ISVRACESRM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DLLRAVIIGA | EGTPYHDGLF | FFDIQFPDTY | PSVPPNVHYH | SGGLRINPNL | YNCGKVCLSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGTWAGSARE | KWLPNESTML | QLLVSIQALI | LNEKPYFNEP | GYVQSAGTAS | GESKSKVYSE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NVFLLSLKTM | VYSIRRPPQH | FEEYVQNHYF | VRSHDIVKAC | NAYKAGAPLG | SMVKGGVQDL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EEARQSGSKK | FKTDVASFMQ | TVVDEFVKLG | VKELAEKPEP | PMSNANTENQ | SKKKTRKRSR |
| SSR |