Q9ESZ8

PR
Gene name
Gtf2i (Bap135, Diws1t)
Protein name
General transcription factor II-I
Names
GTFII-I, TFII-I, Bruton tyrosine kinase-associated protein 135, BAP-135, BTK-associated protein 135
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14886
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9ESZ8

Entry ID Method Resolution Chain Position Source
1Q60 NMR - A 733-818 PDB
AF-Q9ESZ8-F1 Predicted AlphaFoldDB

37 variants for Q9ESZ8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs13496556 5 V>A No EVA
rs3388784547 29 A>T No EVA
rs3388778908 30 L>P No EVA
rs3396220244 123 C>Y No EVA
rs3388800864 141 M>L No EVA
rs3388791829 150 V>S No EVA
rs3388791778 157 V>F No EVA
rs3388791834 161 H>Q No EVA
rs3396222444 170 L>* No EVA
rs3388790686 207 S>Y No EVA
rs3388765699 228 S>Y No EVA
rs3396293235 229 G>A No EVA
rs3388778859 308 V>I No EVA
rs3388765685 311 T>I No EVA
rs3388793130 332 P>S No EVA
rs3388778878 360 D>V No EVA
rs3388796948 402 L>F No EVA
rs234710952 500 N>S No EVA
rs3388791769 548 T>I No EVA
rs3388796511 576 E>G No EVA
rs3388784517 602 S>Y No EVA
rs3388796871 623 W>C No EVA
rs3388782525 647 E>K No EVA
rs3388804430 703 T>N No EVA
rs3388798433 729 K>T No EVA
rs3388796913 744 K>T No EVA
rs3388798408 775 P>S No EVA
rs3388782560 812 E>* No EVA
rs3388798474 854 D>G No EVA
rs3388793123 872 V>I No EVA
rs3388778862 910 P>S No EVA
rs1134732018 934 E>D No EVA
rs3388790613 949 I>S No EVA
rs3388790652 950 N>K No EVA
rs3388788191 969 E>D No EVA
rs3388793099 983 E>V No EVA
rs3388793108 984 T>S No EVA

No associated diseases with Q9ESZ8

6 regional properties for Q9ESZ8

Type Name Position InterPro Accession
repeat GTF2I-like repeat 103 - 197 IPR004212-1
repeat GTF2I-like repeat 352 - 446 IPR004212-2
repeat GTF2I-like repeat 457 - 551 IPR004212-3
repeat GTF2I-like repeat 562 - 656 IPR004212-4
repeat GTF2I-like repeat 724 - 818 IPR004212-5
repeat GTF2I-like repeat 859 - 953 IPR004212-6

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Colocalizes with BTK in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.

3 GO annotations of biological process

Name Definition
negative regulation of angiogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of cytosolic calcium ion concentration Any process that decreases the concentration of calcium ions in the cytosol.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A7MB80 GTF2I General transcription factor II-I Bos taurus (Bovine) PR
A4IFA3 GTF2IRD2 General transcription factor II-I repeat domain-containing protein 2 Bos taurus (Bovine) PR
Q9UHL9 GTF2IRD1 General transcription factor II-I repeat domain-containing protein 1 Homo sapiens (Human) PR
P78347 GTF2I General transcription factor II-I Homo sapiens (Human) PR
Q6EKJ0 GTF2IRD2B General transcription factor II-I repeat domain-containing protein 2B Homo sapiens (Human) PR
Q86UP8 GTF2IRD2 General transcription factor II-I repeat domain-containing protein 2A Homo sapiens (Human) PR
Q9JI57 Gtf2ird1 General transcription factor II-I repeat domain-containing protein 1 Mus musculus (Mouse) PR
Q5U2Y1 Gtf2i General transcription factor II-I Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
70 80 90 100 110 120
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF
130 140 150 160 170 180
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI
190 200 210 220 230 240
SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK
250 260 270 280 290 300
EESEDPDYYQ YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS
310 320 330 340 350 360
ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN FEKWNARITD
370 380 390 400 410 420
LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE
430 440 450 460 470 480
RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE
490 500 510 520 530 540
ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR
550 560 570 580 590 600
PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF
610 620 630 640 650 660
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV SYLPPGMASK
670 680 690 700 710 720
INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA VRTPTQTNGS NVPFKPRGRE
730 740 750 760 770 780
FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF
790 800 810 820 830 840
RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG
850 860 870 880 890 900
VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN
910 920 930 940 950 960
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE
970 980 990
GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW