AiPD: Autoinhibited Protein Database

Gene name	Gtf2ird1 (Ben)
Protein name	General transcription factor II-I repeat domain-containing protein 1
Names	GTF2I repeat domain-containing protein 1, Binding factor for early enhancer
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:57080
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

984-1067 (Predicted disordered autoinhibitory region) PR

984-1067 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9JI57-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388795802	6	K>E	No	EVA
rs3388788194	83	D>N	No	EVA
rs3388798491	94	N>S	No	EVA
rs3388798679	122	C>*	No	EVA
rs3388788132	129	Q>K	No	EVA
rs3388778849	210	D>E	No	EVA
rs3388798184	236	A>G	No	EVA
rs3388798122	236	A>T	No	EVA
rs3388798666	250	P>L	No	EVA
rs3388804442	274	V>M	No	EVA
rs3388800834	283	D>H	No	EVA
rs3388791822	294	H>Y	No	EVA
rs3388778847	307	Q>*	No	EVA
rs3388786394	318	Q>K	No	EVA
rs3388788168	329	S>P	No	EVA
rs3388793126	357	I>F	No	EVA
rs3388798635	385	E>*	No	EVA
rs3388804360	428	D>VSDG*	No	EVA
rs3388796532	440	D>Y	No	EVA
rs3388788115	445	E>D	No	EVA
rs3388798200	446	P>S	No	EVA
rs3388800892	467	G>V	No	EVA
rs3388796881	469	A>V	No	EVA
rs3388804389	478	E>D	No	EVA
rs3388790624	498	P>VSDG*	No	EVA
rs3388793163	502	D>G	No	EVA
rs3388786405	552	R>W	No	EVA
rs3388782557	604	L>V	No	EVA
rs3388796512	618	F>S	No	EVA
rs3388791759	624	R>E*	No	EVA
rs3388786260	625	K>R	No	EVA
rs3388795880	628	E>G	No	EVA
rs3396202162	705	A>P	No	EVA
rs3396087862	709	K>*	No	EVA
rs3396002787	709	K>R	No	EVA
rs3396002792	710	Y>C	No	EVA
rs3388790662	712	V>A	No	EVA
rs3388790662	712	V>E	No	EVA
rs3388800841	712	V>L	No	EVA
rs3388800816	720	K>Q	No	EVA
rs3388796911	741	C>Y	No	EVA
rs3388788189	743	F>L	No	EVA
rs3388791755	754	V>M	No	EVA
rs3388796870	757	K>R	No	EVA
rs3388796476	805	A>T	No	EVA
rs3388796497	809	G>W	No	EVA
rs3388784595	824	E>D	No	EVA
rs3388782576	824	E>K	No	EVA
rs3388768445	839	P>L	No	EVA
rs3388795811	878	A>D	No	EVA
rs3388796502	920	Q>E	No	EVA
rs3388768438	922	K>SDG*	No	EVA
rs3388782505	924	L>F	No	EVA
rs3388778907	973	H>Q	No	EVA
rs3388796536	998	D>N	No	EVA
rs3388765667	1013	K>M	No	EVA
rs3388790646	1082	H>P	No	EVA
rs3388765632	1083	W>R	No	EVA
rs3388804354	1086	R>K	No	EVA

Type	Name	Position	InterPro Accession
repeat	GTF2I-like repeat	119 - 213	IPR004212-1
repeat	GTF2I-like repeat	342 - 436	IPR004212-2
repeat	GTF2I-like repeat	556 - 650	IPR004212-3
repeat	GTF2I-like repeat	681 - 775	IPR004212-4
repeat	GTF2I-like repeat	805 - 899	IPR004212-5
repeat	GTF2I-like repeat	908 - 1002	IPR004212-6

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

Name	Definition
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transition between slow and fast fiber	The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A7MB80	GTF2I	General transcription factor II-I	Bos taurus (Bovine)	PR
A4IFA3	GTF2IRD2	General transcription factor II-I repeat domain-containing protein 2	Bos taurus (Bovine)	PR
P78347	GTF2I	General transcription factor II-I	Homo sapiens (Human)	PR
Q9UHL9	GTF2IRD1	General transcription factor II-I repeat domain-containing protein 1	Homo sapiens (Human)	PR
Q6EKJ0	GTF2IRD2B	General transcription factor II-I repeat domain-containing protein 2B	Homo sapiens (Human)	PR
Q86UP8	GTF2IRD2	General transcription factor II-I repeat domain-containing protein 2A	Homo sapiens (Human)	PR
Q9ESZ8	Gtf2i	General transcription factor II-I	Mus musculus (Mouse)	PR