A4IFA3
PR
Gene name |
GTF2IRD2 |
Protein name |
General transcription factor II-I repeat domain-containing protein 2 |
Names |
GTF2I repeat domain-containing protein 2, Transcription factor GTF2IRD2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:539745 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A4IFA3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A4IFA3-F1 | Predicted | AlphaFoldDB |
148 variants for A4IFA3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs459500188 | 34 | C>F | No | EVA | |
| rs438673786 | 46 | C>S | No | EVA | |
| rs482826287 | 78 | K>R | No | EVA | |
| rs462041241 | 79 | Y>* | No | EVA | |
| rs449998500 | 79 | Y>S | No | EVA | |
| rs475910457 | 80 | C>* | No | EVA | |
| rs480791855 | 80 | C>G | No | EVA | |
| rs443012383 | 82 | A>S | No | EVA | |
| rs461580150 | 88 | V>A | No | EVA | |
| rs440674509 | 89 | K>Q | No | EVA | |
| rs459225794 | 89 | K>R | No | EVA | |
| rs476757401 | 90 | P>S | No | EVA | |
| rs462446633 | 96 | A>G | No | EVA | |
| rs480943617 | 112 | A>D | No | EVA | |
| rs448115198 | 113 | V>D | No | EVA | |
| rs520856042 | 117 | F>S | No | EVA | |
| rs433811683 | 120 | C>Y | No | EVA | |
| rs715548853 | 140 | T>M | No | EVA | |
| rs476317459 | 161 | N>I | No | EVA | |
| rs461893402 | 162 | Y>* | No | EVA | |
| rs443414662 | 162 | Y>D | No | EVA | |
| rs383801525 | 175 | A>G | No | EVA | |
| rs462624248 | 206 | T>R | No | EVA | |
| rs465354952 | 224 | D>E | No | EVA | |
| rs457389821 | 225 | S>F | No | EVA | |
| rs432394762 | 225 | S>T | No | EVA | |
| rs448401397 | 267 | L>F | No | EVA | |
| rs467725130 | 269 | M>I | No | EVA | |
| rs434820985 | 270 | E>G | No | EVA | |
| rs42071433 | 273 | I>T | No | EVA | |
| rs518321794 | 299 | I>T | No | EVA | |
| rs444921074 | 307 | E>G | No | EVA | |
| rs379118754 | 312 | V>I | No | EVA | |
| rs455743689 | 327 | L>F | No | EVA | |
| rs455815958 | 329 | K>R | No | EVA | |
| rs467903083 | 330 | I>M | No | EVA | |
| rs434901763 | 332 | Q>P | No | EVA | |
| rs469619854 | 335 | E>K | No | EVA | |
| rs453403437 | 335 | E>V | No | EVA | |
| rs438181412 | 340 | L>F | No | EVA | |
| rs438181412 | 340 | L>I | No | EVA | |
| rs452050686 | 350 | G>V | No | EVA | |
| rs464135370 | 353 | F>L | No | EVA | |
| rs437650843 | 359 | Y>S | No | EVA | |
| rs456277769 | 362 | I>M | No | EVA | |
| rs441876668 | 368 | C>F | No | EVA | |
| rs453919478 | 368 | C>W | No | EVA | |
| rs472501059 | 369 | V>L | No | EVA | |
| rs458907746 | 370 | V>G | No | EVA | |
| rs439504219 | 370 | V>L | No | EVA | |
| rs444493619 | 371 | I>F | No | EVA | |
| rs462926366 | 371 | I>S | No | EVA | |
| rs462926366 | 371 | I>T | No | EVA | |
| rs444493619 | 371 | I>V | No | EVA | |
| rs467156665 | 372 | D>A | No | EVA | |
| rs448567150 | 372 | D>N | No | EVA | |
| rs448567150 | 372 | D>Y | No | EVA | |
| rs522820829 | 376 | P>L | No | EVA | |
| rs446309993 | 378 | V>G | No | EVA | |
| rs464159758 | 379 | V>G | No | EVA | |
| rs437638588 | 385 | Y>N | No | EVA | |
| rs468297944 | 388 | I>V | No | EVA | |
| rs385727824 | 400 | L>F | No | EVA | |
| rs453858629 | 404 | T>R | No | EVA | |
| rs472390290 | 405 | V>F | No | EVA | |
| rs433020829 | 407 | R>I | No | EVA | |
| rs476544494 | 488 | Q>L | No | EVA | |
| rs723097785 | 514 | A>T | No | EVA | |
| rs436021291 | 561 | T>N | No | EVA | |
| rs454519726 | 562 | T>P | No | EVA | |
| rs440108630 | 571 | V>G | No | EVA | |
| rs452241842 | 577 | V>G | No | EVA | |
| rs470830785 | 578 | S>* | No | EVA | |
| rs482194846 | 620 | T>N | No | EVA | |
| rs442786160 | 637 | K>N | No | EVA | |
| rs461325458 | 640 | V>A | No | EVA | |
| rs479915858 | 648 | D>E | No | EVA | |
| rs446907826 | 657 | H>Y | No | EVA | |
| rs723545795 | 667 | K>Q | No | EVA | |
| rs465393326 | 675 | V>L | No | EVA | |
| rs477446293 | 678 | A>P | No | EVA | |
| rs451080573 | 684 | S>P | No | EVA | |
| rs469535234 | 688 | N>S | No | EVA | |
| rs436701850 | 689 | H>P | No | EVA | |
| rs454477116 | 694 | T>P | No | EVA | |
| rs466534266 | 701 | C>S | No | EVA | |
| rs433621040 | 710 | T>P | No | EVA | |
| rs444274215 | 714 | W>G | No | EVA | |
| rs456355465 | 716 | S>G | No | EVA | |
| rs474894266 | 720 | V>G | No | EVA | |
| rs461306060 | 724 | F>I | No | EVA | |
| rs473433980 | 724 | F>Y | No | EVA | |
| rs440477867 | 728 | L>M | No | EVA | |
| rs458912388 | 736 | S>P | No | EVA | |
| rs477382934 | 737 | S>T | No | EVA | |
| rs450970407 | 751 | I>T | No | EVA | |
| rs463002119 | 754 | L>V | No | EVA | |
| rs448684782 | 757 | L>P | No | EVA | |
| rs466577398 | 765 | N>K | No | EVA | |
| rs464228018 | 778 | V>E | No | EVA | |
| rs437716134 | 782 | Y>D | No | EVA | |
| rs456292228 | 784 | L>V | No | EVA | |
| rs478624260 | 786 | R>L | No | EVA | |
| rs435474225 | 788 | F>C | No | EVA | |
| rs453983841 | 790 | A>S | No | EVA | |
| rs458796310 | 797 | T>P | No | EVA | |
| rs470872877 | 800 | A>P | No | EVA | |
| rs444508134 | 805 | A>D | No | EVA | |
| rs462938863 | 807 | F>C | No | EVA | |
| rs481719402 | 809 | T>A | No | EVA | |
| rs479382037 | 813 | V>G | No | EVA | |
| rs445628653 | 816 | N>T | No | EVA | |
| rs464168769 | 817 | E>* | No | EVA | |
| rs437651190 | 817 | E>A | No | EVA | |
| rs449853170 | 817 | E>D | No | EVA | |
| rs468384713 | 818 | S>R | No | EVA | |
| rs435413195 | 826 | K>Q | No | EVA | |
| rs453974217 | 828 | V>L | No | EVA | |
| rs433063094 | 830 | L>R | No | EVA | |
| rs452349007 | 831 | K>R | No | EVA | |
| rs470807610 | 832 | T>R | No | EVA | |
| rs444495655 | 833 | E>K | No | EVA | |
| rs456612438 | 834 | F>C | No | EVA | |
| rs475215287 | 839 | S>P | No | EVA | |
| rs442164020 | 842 | K>* | No | EVA | |
| rs460769676 | 843 | L>I | No | EVA | |
| rs479268790 | 843 | L>P | No | EVA | |
| rs479268790 | 843 | L>R | No | EVA | |
| rs526178403 | 844 | Y>* | No | EVA | |
| rs439936380 | 845 | E>Q | No | EVA | |
| rs482657342 | 848 | L>M | No | EVA | |
| rs449785783 | 851 | F>L | No | EVA | |
| rs468272556 | 854 | P>L | No | EVA | |
| rs436077352 | 860 | E>D | No | EVA | |
| rs480367918 | 865 | A>P | No | EVA | |
| rs465988841 | 866 | L>V | No | EVA | |
| rs876160817 | 870 | V>G | No | EVA | |
| rs464383154 | 894 | H>P | No | EVA | |
| rs385087121 | 904 | I>T | No | EVA | |
| rs437987072 | 909 | I>M | No | EVA | |
| rs475074548 | 916 | T>P | No | EVA | |
| rs442117871 | 917 | Y>S | No | EVA | |
| rs454202330 | 934 | C>W | No | EVA | |
| rs439923918 | 939 | D>A | No | EVA | |
| rs458460512 | 942 | W>C | No | EVA | |
| rs482591678 | 946 | L>H | No | EVA | |
| rs443165871 | 947 | H>P | No | EVA | |
| rs461770128 | 948 | I>F | No | EVA |
No associated diseases with A4IFA3
4 regional properties for A4IFA3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | GTF2I-like repeat | 100 - 194 | IPR004212-1 |
| repeat | GTF2I-like repeat | 324 - 418 | IPR004212-2 |
| domain | Domain of unknown function DUF4371 | 547 - 626 | IPR025398 |
| domain | SPIN-DOC-like, zinc-finger | 430 - 491 | IPR040647 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transition between fast and slow fiber | The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7MB80 | GTF2I | General transcription factor II-I | Bos taurus (Bovine) | PR |
| Q6EKJ0 | GTF2IRD2B | General transcription factor II-I repeat domain-containing protein 2B | Homo sapiens (Human) | PR |
| Q86UP8 | GTF2IRD2 | General transcription factor II-I repeat domain-containing protein 2A | Homo sapiens (Human) | PR |
| Q9UHL9 | GTF2IRD1 | General transcription factor II-I repeat domain-containing protein 1 | Homo sapiens (Human) | PR |
| P78347 | GTF2I | General transcription factor II-I | Homo sapiens (Human) | PR |
| Q9JI57 | Gtf2ird1 | General transcription factor II-I repeat domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q9ESZ8 | Gtf2i | General transcription factor II-I | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQVAVSTPP | IAHEESSESR | MVVTFLVSAL | ESMCKELAKS | KAEVACIAMY | EADVFVIGTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGRAFVNART | DLQKDFAKYC | VAEGLQEVKP | PGPANASRMQ | VDSGETEILR | KAVEDYFCFC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YGKALGTAAM | VPVPYEKMLT | DQEAIVVQGL | PEGVPFQHPE | NYDLATLKWI | LENKAGISFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| INRPFPGPAN | QPGGPGVVTD | TDKSVTSPSE | SCTPIRVKTE | PMEDSGISLK | AEVVSVKKES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDPNYYEYSM | QESRHSSAGT | EVIETELPME | DSIQLVPSET | SEDPEAEVKI | EGNTSSPNIT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSAAGVEDLN | IVQVTVPDNE | KERLSSLEKI | KQLREQVNDL | FSRKFGEAIG | VDFPVKVPYR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KITFNPGCVV | IDGMPPGVVF | KAPGYLEISS | MRRILDAADL | IKFTVIRPLP | GLELSNVGKR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KIDQEGRVFQ | EKWERAYFFV | EVQNIPTCLI | CKQSMSVSKE | YNLRRHYQTN | HSKHYDQYTE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KMRDEKLQEL | KEGLRKYLLG | SSDTVCPEQK | QVFAKVNPRE | NAAVQPVEDV | AGNLWEKLRE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KIRSFVAYSI | AIDEITDINN | TTQLAIFIRG | VDENFDVSEE | LLDTVPMTGT | KSGNEIFLRV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EKSLKKFNID | WSKLVSVAST | GTPAMVDAND | GLVTKLKSKV | AMVCKGSDLK | SVCCIIHPES |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LCAQKLKMDH | IMSVVVNAVN | WICSRGLNHS | EFTTLLYELD | CQYGSLLYYT | EIKWLSRGLV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LKRFFESLEE | IDSFMSSRGK | PLPQLSSQDW | IKDLAFLVDM | TMHLNTLNIS | LQGHSQIVTQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MYDLIRAFLA | KLCLWETHLA | RNNLAHFPTL | KSVSRNESDG | LNYIPKIVEL | KTEFQKRLSD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FKLYESELTL | FSSPFSMKIE | SVQEALQMEV | IDLQCNTVLK | TKYDKVGIPE | FYKHLWGSYP |
| 910 | 920 | 930 | 940 | ||
| KYKIHCAKIL | SMFGSTYICE | QLFSIMKLSK | TEYCSQLKDS | QWDSVLHIST |