A7MB80

PR
Gene name
GTF2I
Protein name
General transcription factor II-I
Names
GTFII-I, TFII-I
Species
Bos taurus (Bovine)
KEGG Pathway
bta:534669
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7MB80

Entry ID Method Resolution Chain Position Source
AF-A7MB80-F1 Predicted AlphaFoldDB

64 variants for A7MB80

Variant ID(s) Position Change Description Diseaes Association Provenance
rs478542154 17 S>L No EVA
rs459961343 18 E>A No EVA
rs447717864 63 R>G No EVA
rs439376636 67 N>K No EVA
rs472268452 68 T>A No EVA
rs460168670 68 T>N No EVA
rs477936115 83 E>Q No EVA
rs457812678 97 A>T No EVA
rs520047335 124 Y>* No EVA
rs445886055 124 Y>N No EVA
rs478759817 125 G>R No EVA
rs457056270 138 Y>F No EVA
rs475696320 138 Y>H No EVA
rs433035734 218 V>I No EVA
rs479961209 231 S>Y No EVA
rs481097204 237 V>M No EVA
rs135862085 239 V>G No EVA
rs462377350 243 S>T No EVA
rs444724728 247 D>V No EVA
rs477490846 249 Y>D No EVA
rs458996268 255 A>S No EVA
rs1115343854 261 D>N No EVA
rs456952718 271 K>Q No EVA
rs470556245 296 D>Y No EVA
rs454053388 353 A>V No EVA
rs468405793 355 A>P No EVA
rs481910048 363 T>R No EVA
rs469986359 365 P>L No EVA
rs477962164 367 P>H No EVA
rs440937209 370 Q>E No EVA
rs480238213 375 D>G No EVA
rs462841735 438 W>R No EVA
rs444296062 443 T>A No EVA
rs470005750 470 P>H No EVA
rs445030846 476 A>S No EVA
rs445000060 481 L>I No EVA
rs432864170 495 P>A No EVA
rs520249188 576 Y>H No EVA
rs467593469 587 Y>C No EVA
rs455420377 597 F>S No EVA
rs436904811 602 W>C No EVA
rs469908105 605 I>M No EVA
rs468186498 636 M>K No EVA
rs481252260 677 T>P No EVA
rs718776497 680 V>I No EVA
rs462528298 682 T>P No EVA
rs455623460 751 E>A No EVA
rs450697409 784 I>L No EVA
rs432191918 786 K>T No EVA
rs209182322 794 I>V No EVA
rs460506827 813 S>R No EVA
rs434159160 835 D>E No EVA
rs478867023 866 M>I No EVA
rs460127300 893 V>G No EVA
rs479017556 922 R>S No EVA
rs447606341 924 F>I No EVA
rs462024734 925 P>R No EVA
rs482879210 926 G>R No EVA
rs439236681 928 V>L No EVA
rs472023924 929 I>F No EVA
rs459939378 930 N>K No EVA
rs459220154 951 T>P No EVA
rs447112377 955 V>G No EVA
rs461409413 959 E>* No EVA

No associated diseases with A7MB80

6 regional properties for A7MB80

Type Name Position InterPro Accession
repeat GTF2I-like repeat 103 - 197 IPR004212-1
repeat GTF2I-like repeat 331 - 425 IPR004212-2
repeat GTF2I-like repeat 436 - 530 IPR004212-3
repeat GTF2I-like repeat 541 - 635 IPR004212-4
repeat GTF2I-like repeat 703 - 797 IPR004212-5
repeat GTF2I-like repeat 839 - 933 IPR004212-6

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Colocalizes with BTK in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

1 GO annotations of biological process

Name Definition
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A4IFA3 GTF2IRD2 General transcription factor II-I repeat domain-containing protein 2 Bos taurus (Bovine) PR
Q9UHL9 GTF2IRD1 General transcription factor II-I repeat domain-containing protein 1 Homo sapiens (Human) PR
P78347 GTF2I General transcription factor II-I Homo sapiens (Human) PR
Q6EKJ0 GTF2IRD2B General transcription factor II-I repeat domain-containing protein 2B Homo sapiens (Human) PR
Q86UP8 GTF2IRD2 General transcription factor II-I repeat domain-containing protein 2A Homo sapiens (Human) PR
Q9JI57 Gtf2ird1 General transcription factor II-I repeat domain-containing protein 1 Mus musculus (Mouse) PR
Q9ESZ8 Gtf2i General transcription factor II-I Mus musculus (Mouse) PR
Q5U2Y1 Gtf2i General transcription factor II-I Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAQVAVSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
70 80 90 100 110 120
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTAQAN RMSVDAVEIE TLRKTVEDYF
130 140 150 160 170 180
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI
190 200 210 220 230 240
SFIIKRPFLE PKKHLGGRVM VTDAERSMIS PSGSCGPVKV KTEPSEDSGI SLEMAAVTVK
250 260 270 280 290 300
EESEDPDYYQ YNIQAGPSET DDVDDKLPLS KSLQGSHHSS EGNEGTEMEV PAEDDDYPPP
310 320 330 340 350 360
AKRPKSSEPP QPPVTEPANA GKRKVREFNF EKWNARITDL RKQVEELFER KYAQAIKAKG
370 380 390 400 410 420
PVTIPYPLFQ SHVEDLYVEG LPEGIPFRRP STYGIPRLER ILLAKERIRF VIKKHELLNS
430 440 450 460 470 480
TREDLQLDKP ASGVKEEWYA RITKLRKMVD QLFCKKFAEA LGSTEAKAVP YQKFEAHPND
490 500 510 520 530 540
LYVEGLPENI PFRSPSWYGI PRLEKIIQVG NRIKFVIKRP ELLTHSTTEV TQPRTNTPVK
550 560 570 580 590 600
EDWNVRITKL RKQVEEIFNL KFAQALGLTE AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP
610 620 630 640 650 660
TWFGIPRLER IVRGSNKIKF VVKKPELVIS YLPPGMASKI NTKALQSPKR PRSPGSNSKV
670 680 690 700 710 720
PEIEVTVEGP NNSNPQTSAV RTPTQTNGSN VPFKPRGREF SFEAWNAKIT DLKQKVENLF
730 740 750 760 770 780
NEKCGEALGL KQAVKVPFAL FESFPEDFYV EGLPEGVPFR RPSTFGIPRL EKILRNKAKI
790 800 810 820 830 840
KFIIKKPEMF ETAIKESTSS SKSPPRKINS SPSVNTTASG VEDLNIIQVT IPDDDNERLS
850 860 870 880 890 900
KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN PGCVVVDGMP PGVSFKAPSY
910 920 930 940 950 960
LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE GPVIQESAEP TQLEVPATEE
970
IKETDGNSQI KQEPDPTW