Q5U2Y1

PR
Gene name
Gtf2i
Protein name
General transcription factor II-I
Names
GTFII-I, TFII-I
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:353256
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5U2Y1

Entry ID Method Resolution Chain Position Source
AF-Q5U2Y1-F1 Predicted AlphaFoldDB

No variants for Q5U2Y1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5U2Y1

No associated diseases with Q5U2Y1

6 regional properties for Q5U2Y1

Type Name Position InterPro Accession
repeat GTF2I-like repeat 103 - 197 IPR004212-1
repeat GTF2I-like repeat 333 - 427 IPR004212-2
repeat GTF2I-like repeat 438 - 532 IPR004212-3
repeat GTF2I-like repeat 543 - 637 IPR004212-4
repeat GTF2I-like repeat 705 - 799 IPR004212-5
repeat GTF2I-like repeat 840 - 934 IPR004212-6

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Colocalizes with BTK in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.

3 GO annotations of biological process

Name Definition
negative regulation of angiogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of cytosolic calcium ion concentration Any process that decreases the concentration of calcium ions in the cytosol.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A7MB80 GTF2I General transcription factor II-I Bos taurus (Bovine) PR
P78347 GTF2I General transcription factor II-I Homo sapiens (Human) PR
Q9ESZ8 Gtf2i General transcription factor II-I Mus musculus (Mouse) PR
10 20 30 40 50 60
MAQVAMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
70 80 90 100 110 120
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKCTTQAN RMSVDAVEIE TLRKTVEDYF
130 140 150 160 170 180
CFCYGKALGK STVVPVPYEK MLRDQSAVAV QGLPEGVAFK HPEHYDLATL KWILENKAGI
190 200 210 220 230 240
SFIIKRPFLE PKKHLGGRVM AADADRPMLS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK
250 260 270 280 290 300
EESEDPDYYQ YNIQGSHHSS EGNEGAEVEV PAEDSTQHVP SETSEDPEVE VTIEDDDYSP
310 320 330 340 350 360
PTKRPKSSEP PPPPPVPEPT NAGKRKVREF NFEKWNARIT DLRKQVEELF ERKYAQAIKA
370 380 390 400 410 420
KGPVTIPYPL FQSHVEDLYV EGLPEGIPFR RPSTYGIPRL ERILLAKERI RFVIKKHELL
430 440 450 460 470 480
NSTREDLQLD KPASGVKEEW YARITKLRKM VDQLFCKKFA EALGSTEAKA VPYQKFEAYP
490 500 510 520 530 540
NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK RPELLTHSTT EVTQPRTNTP
550 560 570 580 590 600
VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV FESNPEFLYV EGLPEGIPFR
610 620 630 640 650 660
SPTWFGIPRL ERIVRGSNKI KFVVKKPELV VSYLPPGMAS KINTKALQSP KRPRSPGSNS
670 680 690 700 710 720
KVPEIEVTVE GPNNNSPQTS TVRTPTQTNG SNVPFKPRGR EFSFEAWNAK ITDLKQKVEN
730 740 750 760 770 780
LFNEKCGEAL GLKQAVKVPF ALFESFPEDF YVEGLPEGVP FRRPSTFGIP RLEKILRNKA
790 800 810 820 830 840
KIKFIIKKPE MFETAIKEST SSKSPPRKTN SSPSVNTTAS GVEDLNIIQV TIPDDDNERL
850 860 870 880 890 900
SKVEKARQLR EQVNDLFSRK FGEAIGMGFP VKVPYRKITI NPGCVVVDGM PPGVSFKAPS
910 920 930 940 950 960
YLEISSMRRI LDSAEFIKFT VIRPFPGLVI NNQLVDQNES EGPVIQESAE ASQLEVPATE
970
EIKETDGSSQ IKQEPDPTW