Q9DCN7

PR
Gene name
Rnft1
Protein name
E3 ubiquitin-protein ligase RNFT1
Names
RING finger and transmembrane domain-containing protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:76892
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DCN7

Entry ID Method Resolution Chain Position Source
AF-Q9DCN7-F1 Predicted AlphaFoldDB

20 variants for Q9DCN7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389158950 68 H>P No EVA
rs3389153710 118 I>N No EVA
rs3389198229 148 K>N No EVA
rs3389198259 150 I>V No EVA
rs3389187987 184 H>L No EVA
rs3389198217 194 F>I No EVA
rs3389189957 196 N>K No EVA
rs3389198194 205 W>* No EVA
rs3389153667 211 V>A No EVA
rs3389126216 263 P>A No EVA
rs3389187986 270 I>V No EVA
rs3389158990 274 E>D No EVA
rs3389191237 274 E>K No EVA
rs3389159015 276 G>D No EVA
rs3389164622 294 L>V No EVA
rs3389164575 332 D>G No EVA
rs3401943791 356 E>Q No EVA
rs3402715294 358 C>Y No EVA
rs3389164579 379 C>Y No EVA
rs3389158980 383 W>R No EVA

No associated diseases with Q9DCN7

4 regional properties for Q9DCN7

Type Name Position InterPro Accession
conserved_site Ribosome maturation protein SBDS, conserved site 36 - 55 IPR018023
domain Ribosome maturation protein SDO1/SBDS, central domain 101 - 164 IPR018978
domain Ribosome maturation protein SDO1/SBDS, N-terminal 10 - 93 IPR019783
domain Ribosome maturation protein SDO1/SBDS, C-terminal domain 165 - 230 IPR046928

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Early endosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

2 GO annotations of biological process

Name Definition
positive regulation of ERAD pathway Any process that activates or increases the frequency, rate or extent of ERAD pathway.
protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UKV5 AMFR E3 ubiquitin-protein ligase AMFR Homo sapiens (Human) PR
Q8WU17 RNF139 E3 ubiquitin-protein ligase RNF139 Homo sapiens (Human) PR
Q5M7Z0 RNFT1 E3 ubiquitin-protein ligase RNFT1 Homo sapiens (Human) PR
Q7TMV1 Rnf139 E3 ubiquitin-protein ligase RNF139 Mus musculus (Mouse) PR
Q9R049 Amfr E3 ubiquitin-protein ligase AMFR Mus musculus (Mouse) PR
P90859 F26E4.3 E3 ubiquitin-protein ligase hrd-like protein 1 Caenorhabditis elegans PR
Q7ZWF4 rnf145 RING finger protein 145 Danio rerio (Zebrafish) (Brachydanio rerio) PR
A5WW08 chfr E3 ubiquitin-protein ligase CHFR Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6NZ21 rnft1 E3 ubiquitin-protein ligase RNFT1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MQASCNQLHD PPGTAHEDAA ASPCGHSRST EGSLHPGDVH IQINSGPKEY SENPSSRNPR
70 80 90 100 110 120
SGVCTCAHGC VHGRFRSYSH SEARPPDDFA TESGEHGSGS FSEFRYLFKW LQKSLPYILI
130 140 150 160 170 180
LGIKLVMQHI TGISLGIGLL TTFMYANKSI VNQVFLRERS SKLRCAWLLV FLAGSSVLLY
190 200 210 220 230 240
YTFHSQSLHY SLIFLNPTLE QLSFWEVLWI VGITDFILKF FFMGLKCLIL LVPSFIMPFK
250 260 270 280 290 300
SKGYWYMLLE ELCQYYRIFV PIPVWFRYLI SYGEFGNVTT WSLGILLALL YLILKLLDFF
310 320 330 340 350 360
GHLRTFRQVL RVFFTRPSYG VPASKRQCSD MDGICTICQA EFQKPVLLFC QHIFCEECIT
370 380 390
LWFNREKTCP LCRTVISECI NKWKDGATSS HLQMY