A5WW08

PR
Gene name
chfr (si:dkey-69h6.7)
Protein name
E3 ubiquitin-protein ligase CHFR
Names
Checkpoint with forkhead and RING finger domains protein, RING-type E3 ubiquitin transferase CHFR
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:564271
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

134-251 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5WW08

Entry ID Method Resolution Chain Position Source
AF-A5WW08-F1 Predicted AlphaFoldDB

No variants for A5WW08

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5WW08

No associated diseases with A5WW08

5 regional properties for A5WW08

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 30 - 98 IPR000253
domain Zinc finger, RING-type 277 - 316 IPR001841
conserved_site Zinc finger, RING-type, conserved site 293 - 302 IPR017907
domain Aprataxin and PNK-like factor, PBZ domain 605 - 628 IPR019406
domain E3 ubiquitin-protein ligase CHFR, cysteine rich domain with multizinc binding 441 - 593 IPR040909

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Nucleus, PML body
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PML body A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

6 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic G2/M transition checkpoint A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.
modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UKV5 AMFR E3 ubiquitin-protein ligase AMFR Homo sapiens (Human) PR
Q8WU17 RNF139 E3 ubiquitin-protein ligase RNF139 Homo sapiens (Human) PR
Q5M7Z0 RNFT1 E3 ubiquitin-protein ligase RNFT1 Homo sapiens (Human) PR
Q9DCN7 Rnft1 E3 ubiquitin-protein ligase RNFT1 Mus musculus (Mouse) PR
Q7TMV1 Rnf139 E3 ubiquitin-protein ligase RNF139 Mus musculus (Mouse) PR
Q9R049 Amfr E3 ubiquitin-protein ligase AMFR Mus musculus (Mouse) PR
P90859 F26E4.3 E3 ubiquitin-protein ligase hrd-like protein 1 Caenorhabditis elegans PR
Q7ZWF4 rnf145 RING finger protein 145 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTNQDSDQAW GKLVKVDASP GSEIVLINSE CTVGRKKDCD LSFPANKLVS GNHCKITHDQ
70 80 90 100 110 120
NSGKVWLEDM STNGTVINMS KVVKKQTHLL QNGDVIYFVY RKNEPEQNIA YVYQSITPQE
130 140 150 160 170 180
SASHDVEDAG REEDSDLTET ESEPAPVEPV IVKPLPQSGH EDPQPSTSSS SLHFYNMPLS
190 200 210 220 230 240
TCSDVSARKN PVSSSAVCKG DSTSSGSPAQ TRLKWTCWTD GEPEEEMQRK RRKTDRDDPG
250 260 270 280 290 300
FGSAHSDASA DIPLRGASGK EKTEGATTDK MEESLTCIIC QDLLYDCISV QPCMHTFCAA
310 320 330 340 350 360
CYSGWMERSS FCPTCRCPVE RIRKNHILNN LVEAYLLQHP EKCRTEDDLR SMDARNKITQ
370 380 390 400 410 420
DMLQPKVERS FSDEEASSDY LFELSDNDSD ISDMSQPYMM CRQCPGYRKE LSSALWICES
430 440 450 460 470 480
AQSESLAKTA GDGPSTSSDS TTAAPQEFRC PPQASHLICT CCLQPMPDRR FEHLPPQVSP
490 500 510 520 530 540
QHCLVCQKPF CHVYWGCPRI GCHGCLARFS ELNLNDKCLD GVFNGNQYES EVLQNYLSCR
550 560 570 580 590 600
GMSWRHLLQD SLQALQQGLY HLSDYRITAN SFLCYCCGLR TFRELAYKYR ERIPPSELPD
610 620 630
AVTNRPNCYW GRNCRTQVKA HHALKFNHIC EQTRFKN