P90859
Gene name |
F26E4.3 |
Protein name |
E3 ubiquitin-protein ligase hrd-like protein 1 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F26E4.11 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P90859
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P90859-F1 | Predicted | AlphaFoldDB |
No variants for P90859
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P90859 | |||||
No associated diseases with P90859
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| ubiquitin ligase complex | A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum unfolded protein response | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. |
| multicellular organism growth | The increase in size or mass of an entire multicellular organism, as opposed to cell growth. |
| protein K48-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of neuron death | Any process that modulates the frequency, rate or extent of neuron death. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WU17 | RNF139 | E3 ubiquitin-protein ligase RNF139 | Homo sapiens (Human) | PR |
| Q5M7Z0 | RNFT1 | E3 ubiquitin-protein ligase RNFT1 | Homo sapiens (Human) | PR |
| Q9UKV5 | AMFR | E3 ubiquitin-protein ligase AMFR | Homo sapiens (Human) | PR |
| Q9DCN7 | Rnft1 | E3 ubiquitin-protein ligase RNFT1 | Mus musculus (Mouse) | PR |
| Q7TMV1 | Rnf139 | E3 ubiquitin-protein ligase RNF139 | Mus musculus (Mouse) | PR |
| Q9R049 | Amfr | E3 ubiquitin-protein ligase AMFR | Mus musculus (Mouse) | PR |
| Q7ZWF4 | rnf145 | RING finger protein 145 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| A5WW08 | chfr | E3 ubiquitin-protein ligase CHFR | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVVNLLSRS | SFPSVDSYLA | LSVLVAIVAS | VTVFTTFRSQ | PELQKLIEEE | LRNNTRLSSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YGLNIEALSG | HTFFQIAHYI | LSDTTLIWVA | INSYFAILAV | CTRLIIKLTF | KELARQEENV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ARQAFFCYVL | LTIVYLSVVI | GPQKGHRVMP | WMIWGGICAF | LSHLQFITCQ | RLKHISPSCD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RGSQKISFLS | LFLFFVSIAM | TFLISRFQHH | LTWQPAVLLY | FDCLLAVFRS | TYILFRCISS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SRVFSFNPDS | VRHFNYWLEL | ITNFVCELIQ | MLSFAQLLAF | SPGLNLTSIF | FLYHMKLTYN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CMTEQLSRHR | NHKKIFEHIE | RSYPSVKCAN | GDDRCVVCWE | LLGTSRRLPC | SHQFHDWCLM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WWLAQDSSCP | TCRCTIPSPQ | DQIRQPPEVG | NSTRLRFNGG | SFGFVHFPAF | TLEVAANFGP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FFGRAAEPTE | EQLQTMLEQV | REMFPQMSVD | IIMTDLRQSG | SAQSTIENIL | EGRIGMNASF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MPGGVLDDEL | SDESENEIEY | EEPAEIVQEP | DNGRQRTWTK | LSSSSGDEDL | SYYEIQRAKM |
| 550 | 560 | ||||
| IETYRRKYLE | SDKAADLRAM | GITE |