Q6NZ21

PR
Gene name
rnft1 (zgc:77306)
Protein name
E3 ubiquitin-protein ligase RNFT1
Names
RING finger and transmembrane domain-containing protein 1
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:406509
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-153 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NZ21

Entry ID Method Resolution Chain Position Source
AF-Q6NZ21-F1 Predicted AlphaFoldDB

No variants for Q6NZ21

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NZ21

No associated diseases with Q6NZ21

3 regional properties for Q6NZ21

Type Name Position InterPro Accession
conserved_site Clathrin adaptor, mu subunit, conserved site 157 - 177 IPR018240-1
conserved_site Clathrin adaptor, mu subunit, conserved site 253 - 267 IPR018240-2
domain Mu homology domain 157 - 421 IPR028565

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

1 GO annotations of biological process

Name Definition
positive regulation of ERAD pathway Any process that activates or increases the frequency, rate or extent of ERAD pathway.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5M7Z0 RNFT1 E3 ubiquitin-protein ligase RNFT1 Homo sapiens (Human) PR
Q9DCN7 Rnft1 E3 ubiquitin-protein ligase RNFT1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MKLRAQFDRG TYSESKGSFK LRDSLDPMQP EPSSREGNGL SLTLQPELLA RMPGAGSSSG
70 80 90 100 110 120
TETGEDVRVP MGSSSGSTNG RGATSRRMRT ASHSHSHTHG HGHSHEHESD SGESDLESGE
130 140 150 160 170 180
SSSSISELRY LLRWLKKSLP FIVILCAKLV IQHALGLAVA VGLFTTFMYV NKSIQTQVFL
190 200 210 220 230 240
HDRRTNLHCA WLLLFLTSSS LLVFYTFHTQ SLYRCLFFAN ATIDYHNFWE VLWSVGVTNF
250 260 270 280 290 300
ILKFIFMGFK CLILLVPCPL MTYRRRGQWY MLIEEVGQLY QVIAPVPLWF RYLVSYDEMD
310 320 330 340 350 360
TSVGLTLGIL LALLYLIMKL LALYGLSGSL QKTLRTFFSP EVNGAPASPA QIREAGDICP
370 380 390 400 410
ICQADFKQPR VLVCQHIFCE ECIAQWLNQE RTCPLCRTVI TDKVHKWKDG ATSAHLQIY