Q9DCL2
Gene name |
Ciao2a (Fam96a) |
Protein name |
Cytosolic iron-sulfur assembly component 2A |
Names |
MIP18 family protein FAM96A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68250 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9DCL2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9DCL2-F1 | Predicted | AlphaFoldDB |
6 variants for Q9DCL2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389057060 | 24 | H>Q | No | EVA | |
| rs3400187141 | 28 | W>R | No | EVA | |
| rs3400271790 | 30 | P>L | No | EVA | |
| rs3389047761 | 31 | R>G | No | EVA | |
| rs3389047832 | 132 | Q>* | No | EVA | |
| rs3412732480 | 148 | L>I | No | EVA |
No associated diseases with Q9DCL2
1 regional properties for Q9DCL2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SWIRM domain | 266 - 363 | IPR007526 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| CIA complex | The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| iron-sulfur cluster assembly | The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. |
| protein maturation by [4Fe-4S] cluster transfer | The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. |
| protein maturation by iron-sulfur cluster transfer | The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3T0U7 | CIAO2A | Cytosolic iron-sulfur assembly component 2A | Bos taurus (Bovine) | PR |
| Q9H5X1 | CIAO2A | Cytosolic iron-sulfur assembly component 2A | Homo sapiens (Human) | PR |
| Q9D187 | Ciao2b | Cytosolic iron-sulfur assembly component 2B | Mus musculus (Mouse) | PR |
| Q9SR25 | AEL2 | Protein AE7-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERVSGLLSW | TLSRVLWLSG | FSEHGAAWQP | RIMEEKALEV | YDLIRTIRDP | EKPNTLEELE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VVTESCVEVQ | EINEDDYLVI | IKFTPTVPHC | SLATLIGLCL | RVKLQRCLPF | KHKLEIYISE |
| 130 | 140 | 150 | |||
| GTHSTEEDIN | KQINDKERVA | AAMENPNLRE | IVEQCVLEPD |