Q3T0U7

PR
Gene name
CIAO2A
Protein name
Cytosolic iron-sulfur assembly component 2A
Names
MIP18 family protein FAM96A
Species
Bos taurus (Bovine)
KEGG Pathway
bta:512871
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3T0U7

Entry ID Method Resolution Chain Position Source
AF-Q3T0U7-F1 Predicted AlphaFoldDB

No variants for Q3T0U7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3T0U7

No associated diseases with Q3T0U7

No regional properties for Q3T0U7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3T0U7

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
CIA complex The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
protein maturation by [4Fe-4S] cluster transfer The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
protein maturation by iron-sulfur cluster transfer The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H5X1 CIAO2A Cytosolic iron-sulfur assembly component 2A Homo sapiens (Human) PR
Q9D187 Ciao2b Cytosolic iron-sulfur assembly component 2B Mus musculus (Mouse) PR
Q9DCL2 Ciao2a Cytosolic iron-sulfur assembly component 2A Mus musculus (Mouse) PR
Q9SR25 AEL2 Protein AE7-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MERVSGLLSW TLSRFLWLSG LSEPGAARQP RIMEEKALEV YDLIRTIRDP EKPNTLEELE
70 80 90 100 110 120
VVTESCVEVQ EINEDDYLVI IRFTPTVPHC SLATLIGLCL RVKLQRCLPF KHKLEIYISE
130 140 150
GTHSTEEDIN KQINDKERVA AAMENPNLRE IVEQCVLEPD