Q9D187
Gene name |
Ciao2b |
Protein name |
Cytosolic iron-sulfur assembly component 2B |
Names |
Mitotic spindle-associated MMXD complex subunit MIP18 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68523 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D187
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D187-F1 | Predicted | AlphaFoldDB |
6 variants for Q9D187
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389007513 | 67 | V>L | No | EVA | |
| rs3389003273 | 73 | I>V | No | EVA | |
| rs3389005926 | 122 | T>A | No | EVA | |
| rs3388955581 | 142 | V>M | No | EVA | |
| rs3389003205 | 148 | N>I | No | EVA | |
| rs3388985175 | 151 | L>M | No | EVA |
No associated diseases with Q9D187
No regional properties for Q9D187
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9D187 | |||
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| CIA complex | The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| MMXD complex | A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| iron-sulfur cluster assembly | The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. |
| protein maturation by [4Fe-4S] cluster transfer | The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. |
| protein maturation by iron-sulfur cluster transfer | The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3T0U7 | CIAO2A | Cytosolic iron-sulfur assembly component 2A | Bos taurus (Bovine) | PR |
| Q9H5X1 | CIAO2A | Cytosolic iron-sulfur assembly component 2A | Homo sapiens (Human) | PR |
| Q9DCL2 | Ciao2a | Cytosolic iron-sulfur assembly component 2A | Mus musculus (Mouse) | PR |
| Q9SR25 | AEL2 | Protein AE7-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVGGGGSGGG | LLENANPLIY | ERSGERPVTA | GEEDEEVPDS | IDAREIFDLI | RSINDPEHPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLEELNVVEQ | VRIQVSDPES | TVAVAFTPTI | PHCSMATLIG | LSIKVKLLRS | LPQRFKMDVH |
| 130 | 140 | 150 | 160 | ||
| ITPGTHASEH | AVNKQLADKE | RVAAALENTH | LLEVVNQCLS | ARS |