Q99JR1
Gene name |
Sfxn1 |
Protein name |
Sideroflexin-1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14057 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99JR1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99JR1-F1 | Predicted | AlphaFoldDB |
19 variants for Q99JR1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389251156 | 23 | G>A | No | EVA | |
| rs3389295228 | 42 | E>* | No | EVA | |
| rs3389295253 | 87 | M>T | No | EVA | |
| rs3389251198 | 89 | L>P | No | EVA | |
| rs3389298893 | 97 | V>I | No | EVA | |
| rs46250077 | 149 | T>M | No | EVA | |
| rs3389295238 | 181 | P>H | No | EVA | |
| rs3389280440 | 182 | F>Y | No | EVA | |
| rs3403965640 | 188 | A>V | No | EVA | |
| rs3404198620 | 189 | N>S | No | EVA | |
| rs3403753234 | 190 | C>S | No | EVA | |
| rs3404204632 | 193 | I>S | No | EVA | |
| rs3389280477 | 196 | M>T | No | EVA | |
| rs3389283218 | 216 | G>R | No | EVA | |
| rs3389268014 | 254 | K>R | No | EVA | |
| rs3389277065 | 257 | L>* | No | EVA | |
| rs3404501475 | 295 | V>G | No | EVA | |
| rs3389241570 | 318 | F>L | No | EVA | |
| rs3389295263 | 323 | L>S | No | EVA |
No associated diseases with Q99JR1
No regional properties for Q99JR1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q99JR1 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-alanine transmembrane transporter activity | Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. |
| L-serine transmembrane transporter activity | Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. |
| serine transmembrane transporter activity | Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| erythrocyte differentiation | The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. |
| iron ion transport | The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| L-alanine transport | The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| L-serine transport | The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| mitochondrial transmembrane transport | The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| serine import into mitochondrion | The process in which serine is transported from the cytosol into the mitochondrial matrix. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9M8 | SFXN1 | Sideroflexin-1 | Bos taurus (Bovine) | PR |
| Q9H9B4 | SFXN1 | Sideroflexin-1 | Homo sapiens (Human) | PR |
| A5A761 | SFXN1 | Sideroflexin-1 | Sus scrofa (Pig) | PR |
| Q63965 | Sfxn1 | Sideroflexin-1 | Rattus norvegicus (Rat) | PR |
| Q5FC79 | sfxn-5 | Sideroflexin-5 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGEVPPNIN | IKEPRWDQST | FIGRASHFFT | VTDPRNILLT | NEQLENARKV | VHDYRQGIVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGLTENELWR | AKYAYDSAFH | PDTGEKMTLI | GRMSAQVPMN | MTITGCMMTF | YRTTPAVLFW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QWINQSFNAV | VNYTNRSGDA | PLTVNELGTA | YVSATTGAVA | TALGLNALTK | RVSPLIGRFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PFAAVAAANC | INIPLMRQRE | LKVGIPVTDE | NGTRLGESTN | AAKQAITQVV | ISRILMAAPG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MAIPPFIMNT | LEKKAFLKRF | PWMSAPIQVT | LVGFCLVFAT | PLCCALFPQK | SSMSVTSLED |
| 310 | 320 | ||||
| ELQASIQRTH | PEIRRVYFNK | GL |