A5A761

PR
Gene name
SFXN1
Protein name
Sideroflexin-1
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:100049699
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

181-252 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5A761

Entry ID Method Resolution Chain Position Source
AF-A5A761-F1 Predicted AlphaFoldDB

2 variants for A5A761

Variant ID(s) Position Change Description Diseaes Association Provenance
rs693871627 24 R>G No EVA
rs790449405 47 A>V No EVA

No associated diseases with A5A761

No regional properties for A5A761

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A5A761

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
L-alanine transmembrane transporter activity Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid.
L-serine transmembrane transporter activity Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid.
serine transmembrane transporter activity Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid.
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

5 GO annotations of biological process

Name Definition
L-alanine transport The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
L-serine transport The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
mitochondrial transmembrane transport The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
serine import into mitochondrion The process in which serine is transported from the cytosol into the mitochondrial matrix.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9M8 SFXN1 Sideroflexin-1 Bos taurus (Bovine) PR
Q9H9B4 SFXN1 Sideroflexin-1 Homo sapiens (Human) PR
Q99JR1 Sfxn1 Sideroflexin-1 Mus musculus (Mouse) PR
Q63965 Sfxn1 Sideroflexin-1 Rattus norvegicus (Rat) PR
Q5FC79 sfxn-5 Sideroflexin-5 Caenorhabditis elegans PR
10 20 30 40 50 60
MSGELPPNIN IKEPRWDQST FVGRANHFFT VTDPRNILLT NEQLENARKV VHDYRQGIVP
70 80 90 100 110 120
PGLTENELWR AKYIYDSAFH PDTGEKMILI GRMSAQVPMN MTITGCMMTF YRTTPAVLFW
130 140 150 160 170 180
QWINQSFNAV VNYTNRSGDA PLTVNELGTA YVSATTGAVA TALGLNALTK HVSPLIGRFV
190 200 210 220 230 240
PFAAVAAANC INIPLMRQRE LRAGIPVTDE NGNRLGESAN AAKQAITQVV ISRILMAAPG
250 260 270 280 290 300
MAIPPFIMNT LEKKAFLKRF PWMSAPIQVG LVGFCLVFAT PLCCALFPQK SSMSVTSLEA
310 320
ELQAKIRETS PELRRVYFNK GL