Q5E9M8
Gene name |
SFXN1 |
Protein name |
Sideroflexin-1 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:511375 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5E9M8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5E9M8-F1 | Predicted | AlphaFoldDB |
45 variants for Q5E9M8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs381540168 | 46 | A>V | No | EVA | |
| rs474661069 | 54 | Y>* | No | EVA | |
| rs440086548 | 54 | Y>C | No | EVA | |
| rs460204308 | 54 | Y>H | No | EVA | |
| rs480041909 | 137 | S>R | No | EVA | |
| rs432985045 | 179 | F>S | No | EVA | |
| rs447407861 | 183 | A>S | No | EVA | |
| rs478714438 | 191 | I>V | No | EVA | |
| rs461767938 | 195 | L>F | No | EVA | |
| rs448033431 | 197 | R>S | No | EVA | |
| rs452119886 | 200 | E>D | No | EVA | |
| rs432025388 | 206 | P>A | No | EVA | |
| rs472991973 | 210 | E>D | No | EVA | |
| rs137082392 | 213 | N>T | No | EVA | |
| rs440390796 | 277 | V>L | No | EVA | |
| rs472526471 | 280 | T>S | No | EVA | |
| rs455611706 | 281 | P>A | No | EVA | |
| rs435407577 | 283 | C>F | No | EVA | |
| rs456183638 | 289 | Q>* | No | EVA | |
| rs477246212 | 293 | M>I | No | EVA | |
| rs460139451 | 294 | S>A | No | EVA | |
| rs440156239 | 294 | S>C | No | EVA | |
| rs474558314 | 295 | V>G | No | EVA | |
| rs454457576 | 296 | T>K | No | EVA | |
| rs444052763 | 298 | L>F | No | EVA | |
| rs475373023 | 299 | E>A | No | EVA | |
| rs452794963 | 299 | E>D | No | EVA | |
| rs432632221 | 300 | A>P | No | EVA | |
| rs467198816 | 300 | A>V | No | EVA | |
| rs436580642 | 301 | E>A | No | EVA | |
| rs453568971 | 301 | E>K | No | EVA | |
| rs451000562 | 302 | L>V | No | EVA | |
| rs465278419 | 305 | R>T | No | EVA | |
| rs445939268 | 307 | R>* | No | EVA | |
| rs477389773 | 307 | R>L | No | EVA | |
| rs460274837 | 311 | P>T | No | EVA | |
| rs481007034 | 313 | L>F | No | EVA | |
| rs440192986 | 313 | L>I | No | EVA | |
| rs460896821 | 317 | Y>D | No | EVA | |
| rs444065838 | 317 | Y>S | No | EVA | |
| rs475447854 | 319 | N>D | No | EVA | |
| rs451970480 | 319 | N>K | No | EVA | |
| rs438373597 | 320 | K>E | No | EVA | |
| rs438373597 | 320 | K>Q | No | EVA | |
| rs473736969 | 322 | L>V | No | EVA |
No associated diseases with Q5E9M8
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-alanine transmembrane transporter activity | Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. |
| L-serine transmembrane transporter activity | Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. |
| serine transmembrane transporter activity | Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| L-alanine transport | The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| L-serine transport | The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| mitochondrial transmembrane transport | The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| serine import into mitochondrion | The process in which serine is transported from the cytosol into the mitochondrial matrix. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H9B4 | SFXN1 | Sideroflexin-1 | Homo sapiens (Human) | PR |
| Q99JR1 | Sfxn1 | Sideroflexin-1 | Mus musculus (Mouse) | PR |
| A5A761 | SFXN1 | Sideroflexin-1 | Sus scrofa (Pig) | PR |
| Q63965 | Sfxn1 | Sideroflexin-1 | Rattus norvegicus (Rat) | PR |
| Q5FC79 | sfxn-5 | Sideroflexin-5 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGELPPNIN | IKEPRWDQST | FIGRAKHFFT | VTDPRNILLT | NEQLEAARKV | VHDYRQGIIP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGLTENELWR | AKYIYDSAFH | PDTGEKMILI | GRMSAQVPMN | MTITGCMMTF | YRTTPAVLFW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QWINQSFNAV | VNYTNRSGDA | PLTVNELGTA | YVSATTGAVA | TALGLNALTK | HVSPLIGRFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PFAAVAAANC | INIPLMRQRE | LKVGIPVTDE | NGNRLGESAN | AAKQAITQVV | VSRILMAAPG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MAIPPFIMNT | LEKKAFLKRF | PWMSAPVQVG | IVGFCLVFAT | PLCCALFPQK | SSMSVTSLEA |
| 310 | 320 | ||||
| ELQARIRETY | PELRRVYFNK | GL |