AiPD: Autoinhibited Protein Database

Q96QE2

Gene name	SLC2A13
Protein name	Proton myo-inositol cotransporter
Names	H(+)-myo-inositol cotransporter, Hmit, H(+)-myo-inositol symporter, Solute carrier family 2 member 13
Species	Homo sapiens (Human)
KEGG Pathway	hsa:114134
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-94 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-94 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96QE2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96QE2-F1	Predicted				AlphaFoldDB

479 variants for Q96QE2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA384585705 rs925293886	3	R>C		No	ClinGen gnomAD
rs925293886 CA235902855	3	R>G		No	ClinGen gnomAD
rs1178245523 CA384585702	3	R>L		No	ClinGen gnomAD
CA384585686 rs1471468439	6	S>G		No	ClinGen gnomAD
CA6512941 rs139518863	6	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	6	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs953971363 CA384585655	10	E>A		No	ClinGen gnomAD
rs953971363 CA235902854	10	E>G		No	ClinGen gnomAD
CA384585638 rs1469023595	12	T>M		No	ClinGen gnomAD
CA384585631 rs1275296746	14	R>W		No	ClinGen gnomAD
rs1316443685 CA384585622	15	S>I		No	ClinGen gnomAD
CA384585624 rs1316443685	15	S>N		No	ClinGen gnomAD
CA384585620 rs1285097801	15	S>R		No	ClinGen TOPMed gnomAD
rs748608502 CA6512940	17	S>R		No	ClinGen ExAC gnomAD
rs1300980302 CA384585583	21	G>C		No	ClinGen gnomAD
rs1489096621 CA384585580	21	G>V		No	ClinGen TOPMed
rs1439905334 CA384585577	22	E>*		No	ClinGen TOPMed gnomAD
TCGA novel	22	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs946250584 CA235902852	22	E>D		No	ClinGen TOPMed
CA384585579 rs1439905334	22	E>Q		No	ClinGen TOPMed gnomAD
CA384585571 rs1371206699	23	R>W		No	ClinGen gnomAD
CA384585567 rs1426219998	24	R>S		No	ClinGen TOPMed
CA384585555 rs1327530841	25	R>S		No	ClinGen gnomAD
rs1451225841 CA384585534	28	P>Q		No	ClinGen TOPMed gnomAD
CA384585533 rs1451225841	28	P>R		No	ClinGen TOPMed gnomAD
CA235902851 rs913513428	29	E>K		No	ClinGen TOPMed gnomAD
CA384585521 rs987617264	30	P>L		No	ClinGen TOPMed gnomAD
rs987617264 CA235902850	30	P>Q		No	ClinGen TOPMed gnomAD
TCGA novel	31	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384585511 rs1159264644	32	A>P		No	ClinGen gnomAD
rs1402944975 CA384585507	32	A>V		No	ClinGen gnomAD
CA235902849 rs955082550	36	A>P		No	ClinGen TOPMed
CA235902848 rs868609933	37	G>V		No	ClinGen Ensembl
TCGA novel	38	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1288505227 CA384585451	41	L>F		No	ClinGen TOPMed
CA235902844 rs1015393959	42	L>M		No	ClinGen Ensembl
rs1454996917 CA384585427	45	A>D		No	ClinGen gnomAD
rs921694865 CA235902841	47	S>L		No	ClinGen TOPMed
CA384585406 rs1186876997	48	S>I		No	ClinGen gnomAD
CA384585403 rs1592087932	49	T>P		No	ClinGen Ensembl
rs557242708 CA235902839	50	S>I		No	ClinGen 1000Genomes TOPMed gnomAD
rs557242708 CA235902840	50	S>N		No	ClinGen 1000Genomes TOPMed gnomAD
CA384585373 rs1218122301	53	S>I		No	ClinGen gnomAD
CA384585366 rs865827185	54	A>G		No	ClinGen TOPMed gnomAD
CA235902837 rs865827185	54	A>V		No	ClinGen TOPMed gnomAD
CA6512938 rs768073140	56	A>S		No	ClinGen ExAC
rs538841712 CA6512937	56	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	57	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6512936 rs779892258	58	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1305413174 CA384585339	59	G>V		No	ClinGen TOPMed gnomAD
CA235902836 rs745713466	60	G>D		No	ClinGen ExAC TOPMed gnomAD
rs755803525 CA6512935	60	G>S		No	ClinGen ExAC
CA6512934 rs745713466	60	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1001866247 CA384585332	61	V>D		No	ClinGen TOPMed
rs1001866247 CA235902835	61	V>G		No	ClinGen TOPMed
CA384585335 rs1480651884	61	V>I		No	ClinGen TOPMed gnomAD
rs1480651884 CA384585334	61	V>L		No	ClinGen TOPMed gnomAD
CA6512932 CA6512931 rs757006339	62	G>R		No	ClinGen ExAC gnomAD
rs757006339 CA384585330	62	G>W		No	ClinGen ExAC gnomAD
rs1242223779 CA384585326	63	D>N		No	ClinGen TOPMed gnomAD
CA384585288 rs1158042385	68	A>V		No	ClinGen TOPMed
CA384585287 rs1361117253	69	R>G		No	ClinGen TOPMed gnomAD
CA235902832 rs950619369	70	R>W		No	ClinGen TOPMed gnomAD
rs764057239 CA6512929	71	Q>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	71	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6512928 rs755056712	72	F>I		No	ClinGen ExAC TOPMed gnomAD
rs868571276 CA235902831	72	F>L		No	ClinGen Ensembl
CA384585243 rs760884647 CA384585242	75	D>E		No	ClinGen ExAC gnomAD
rs1255274042 CA384585239	76	E>*		No	ClinGen gnomAD
rs1046622440 CA235902830	76	E>G		No	ClinGen TOPMed gnomAD
CA384585240 rs1255274042	76	E>K		No	ClinGen gnomAD
CA384585233 rs1305254946	77	T>A		No	ClinGen TOPMed
rs773356809 CA384585230	77	T>I		No	ClinGen ExAC gnomAD
rs773356809 CA6512924	77	T>S		No	ClinGen ExAC gnomAD
CA384585229 rs1282188585	78	P>A		No	ClinGen TOPMed gnomAD
CA384585224 rs1565629951	78	P>L		No	ClinGen Ensembl
CA384585227 rs1282188585	78	P>S		No	ClinGen TOPMed gnomAD
CA6512923 rs767788035	79	A>S		No	ClinGen ExAC TOPMed gnomAD
CA384585192 rs1311799910	83	V>A		No	ClinGen gnomAD
rs1352985142 CA384585195	83	V>L		No	ClinGen gnomAD
CA384585188 rs1377869585	84	V>L		No	ClinGen TOPMed gnomAD
CA384585183 rs1461811194	85	A>T		No	ClinGen gnomAD
CA6512919 rs775125127	86	V>F		No	ClinGen ExAC TOPMed gnomAD
CA384585178 rs775125127	86	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6512918 rs775125127	86	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1474374571 CA384585174	87	F>I		No	ClinGen gnomAD
rs780836152 CA6512915	91	G>S		No	ClinGen ExAC gnomAD
rs1480203926 CA384585139	92	G>D		No	ClinGen gnomAD
CA384585144 rs1193807948	92	G>S		No	ClinGen gnomAD
rs758321917 CA6512911	97	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA6512908 rs756131221	99	T>I		No	ClinGen ExAC gnomAD
CA384585093 rs756131221	99	T>N		No	ClinGen ExAC gnomAD
CA6512906 rs767738927	100	G>R		No	ClinGen ExAC TOPMed gnomAD
rs751930298 CA6512904	101	V>M		No	ClinGen ExAC TOPMed gnomAD
CA384585032 rs1370076979	110	K>Q		No	ClinGen gnomAD
rs776070011 CA6512901	110	K>R		No	ClinGen ExAC TOPMed gnomAD
rs776070011 CA384585028	110	K>T		No	ClinGen ExAC TOPMed gnomAD
CA235902825 rs866386599	111	R>L		No	ClinGen Ensembl
CA6512900 rs377169528	111	R>W		No	ClinGen ESP ExAC gnomAD
CA6512899 rs759063094	112	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs776190692 CA6512898	113	L>F		No	ClinGen ExAC TOPMed gnomAD
CA384585005 rs1272167368	114	S>I		No	ClinGen TOPMed gnomAD
CA384585007 rs1272167368	114	S>N		No	ClinGen TOPMed gnomAD
CA384585004 rs1438779946	114	S>R		No	ClinGen TOPMed gnomAD
CA384584989 rs1258481734	117	A>T		No	ClinGen gnomAD
rs1309514458 CA384584972	119	W>C		No	ClinGen gnomAD
CA384584965 rs1195981382	120	Q>R		No	ClinGen TOPMed
CA384584951 rs1370460022	122	L>P		No	ClinGen TOPMed gnomAD
rs748092714 CA6512893	124	V>A		No	ClinGen ExAC gnomAD
rs778773485 CA6512892	126	S>G		No	ClinGen ExAC TOPMed gnomAD
rs778773485 CA384584932	126	S>R		No	ClinGen ExAC TOPMed gnomAD
CA384584921 rs1158126836	127	T>K		No	ClinGen gnomAD
CA384584922 rs1158126836	127	T>R		No	ClinGen gnomAD
rs756217326 CA6512891	128	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1160176897 CA384584903	130	A>V		No	ClinGen gnomAD
CA384584900 rs1354471292	131	A>S		No	ClinGen TOPMed
CA235902823 rs921216683	132	A>T		No	ClinGen TOPMed
CA384584882 rs1419580750	134	S>W		No	ClinGen TOPMed gnomAD
CA235902820 rs908990457	137	A>V		No	ClinGen TOPMed gnomAD
rs976674575 CA235902818	139	G>S		No	ClinGen Ensembl
rs983076323 CA235902816	140	A>T		No	ClinGen TOPMed
CA384584847 rs1484840929	140	A>V		No	ClinGen TOPMed
CA6512887 rs751933707	142	N>S		No	ClinGen ExAC TOPMed gnomAD
CA235902815 rs1024606509	144	V>A		No	ClinGen TOPMed gnomAD
rs369644372 CA6512885	149	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369644372 CA6512884	149	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	150	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382862530 CA384584789	150	A>S		No	ClinGen TOPMed gnomAD
CA384584790 rs1382862530	150	A>T		No	ClinGen TOPMed gnomAD
rs1434229239 CA384584782	151	I>N		No	ClinGen TOPMed
CA384584784 rs1592087441	151	I>V		No	ClinGen Ensembl
CA384584776 rs1300000370	152	L>F		No	ClinGen gnomAD
rs1394232883 CA384584751	156	A>S		No	ClinGen gnomAD
CA384584748 rs1374014927	156	A>V		No	ClinGen TOPMed
rs1432555306 CA384584728	159	T>I		No	ClinGen TOPMed
rs186341127 CA384584724	160	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776195804 CA6512881	160	A>T		No	ClinGen ExAC TOPMed gnomAD
rs186341127 CA6512880	160	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1447106142 CA384584713	162	S>C		No	ClinGen gnomAD
CA6512879 rs760382450	163	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1001866833 CA235902814	163	A>V		No	ClinGen TOPMed gnomAD
rs771878289 CA6512877	166	A>G		No	ClinGen ExAC gnomAD
CA6512876 rs747898136	167	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6512875 rs774312850	167	A>V		No	ClinGen ExAC TOPMed gnomAD
CA384584685 rs1328246783	168	A>S		No	ClinGen gnomAD
CA384584675 rs1291572310	169	N>K		No	ClinGen gnomAD
rs745992233 CA6512873	170	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6512872 rs781326099	171	K>N		No	ClinGen ExAC gnomAD
rs1415981200 CA384584647	173	T>I		No	ClinGen TOPMed gnomAD
rs757215749 CA6512871	173	T>S		No	ClinGen ExAC gnomAD
CA6512870 rs747266896	176	A>V		No	ClinGen ExAC gnomAD
CA235902812 rs12815421	177	G>A		No	ClinGen Ensembl
rs1300756708 CA384584622	178	R>H		No	ClinGen gnomAD
rs758861667 CA6512868	179	L>P		No	ClinGen ExAC gnomAD
rs1592087314 CA384584610	180	V>G		No	ClinGen Ensembl
rs1212628483 CA384584615	180	V>I		No	ClinGen gnomAD
CA384584551 rs1456454266	187	I>T		No	ClinGen TOPMed
rs1269189401 CA384584554	187	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1278668094 CA384584535	190	M>V		No	ClinGen gnomAD
TCGA novel	195	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384584495 rs758683743	196	I>L		No	ClinGen ExAC TOPMed gnomAD
CA6512850 rs758683743	196	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6512849 rs748594494	197	A>V		No	ClinGen ExAC gnomAD
rs755242782 CA6512847	198	E>A		No	ClinGen ExAC gnomAD
rs754392923 CA6512846	199	V>I		No	ClinGen ExAC TOPMed gnomAD
rs766757270 CA6512845	203	N>S		No	ClinGen ExAC gnomAD
TCGA novel	204	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs17458163 CA235896431	206	G>A		No	ClinGen Ensembl
rs1441961214 CA384584427	207	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs143000031 CA6512844	207	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	208	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA235896430 rs539503212	212	N>K		No	ClinGen 1000Genomes
rs201782676 CA6512841	213	T>N		No	ClinGen 1000Genomes ExAC gnomAD
rs201782676 CA6512840	213	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA384584372 rs1248521956	216	I>V		No	ClinGen gnomAD
rs200122745 CA6512839	221	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1336083100 CA384584336	221	F>Y		No	ClinGen TOPMed
CA6512838 rs762604080	223	A>G		No	ClinGen ExAC gnomAD
rs1481690292 CA384584315	224	S>N		No	ClinGen TOPMed
CA6512836 rs769583915	225	V>G		No	ClinGen ExAC gnomAD
CA235896429 rs976591878	229	A>G		No	ClinGen TOPMed gnomAD
CA6512835 rs200579771	229	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA235896428 rs965174191	231	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6512833 rs368001135	232	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs368001135 CA6512834	232	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs112103961 CA384584259	233	L>H		No	ClinGen gnomAD
rs112103961 CA235896427	233	L>P		No	ClinGen gnomAD
CA384584243 rs1207255736	235	K>N		No	ClinGen TOPMed gnomAD
rs779230404 CA6512831	236	D>G		No	ClinGen ExAC
rs1393641321 CA384584234	237	G>R		No	ClinGen gnomAD
rs1034404828 CA235896425	238	W>*		No	ClinGen Ensembl
rs1348065385 CA384584222	238	W>C		No	ClinGen TOPMed
rs1164071058 CA384584226	238	W>R		No	ClinGen TOPMed
CA6512810 rs780277498	239	R>S		No	ClinGen ExAC gnomAD
rs781626838 CA6512807	241	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs770129674 CA384584188	241	M>L		No	ClinGen ExAC TOPMed gnomAD
rs746386047 CA6512808	241	M>T		No	ClinGen ExAC TOPMed gnomAD
CA6512809 rs770129674	241	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1483434126 CA384584160	245	A>G		No	ClinGen gnomAD
TCGA novel	246	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384584147 rs1257568175	247	V>A		No	ClinGen gnomAD
rs756788970 CA6512806	248	P>L		No	ClinGen ExAC TOPMed gnomAD
rs200980396 CA6512804	249	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs77384712 CA235894464	250	V>G		No	ClinGen Ensembl
rs757985790 CA384584130	251	I>L		No	ClinGen ExAC TOPMed gnomAD
CA384584125 rs544578794	251	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6512803 rs757985790	251	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384584104 rs1397155244	254	F>S		No	ClinGen TOPMed gnomAD
rs200453579 CA235894463	255	G>C		No	ClinGen Ensembl
TCGA novel	255	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759358485 CA235894462	259	L>F		No	ClinGen ExAC TOPMed gnomAD
CA384584045 rs1565596310	263	P>A		No	ClinGen Ensembl
CA235894461 rs954622172	264	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA384584035 rs1461609766	265	W>R		No	ClinGen gnomAD
rs28370680 CA6512799	267	I>F		No	ClinGen ExAC gnomAD
rs1172888730 CA384584010	268	Q>R		No	ClinGen gnomAD
rs766389341 CA6512798	270	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs1417291751 CA384583986	271	Q>H		No	ClinGen gnomAD
rs774283512 CA6512796	273	Q>R		No	ClinGen ExAC gnomAD
rs1424345508 CA384583968	274	K>R		No	ClinGen gnomAD
TCGA novel	275	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763089455 CA6512794	276	R>C		No	ClinGen ExAC gnomAD
CA6512793 rs775723584	276	R>H		No	ClinGen ExAC gnomAD
rs1159238512 CA384583916	282	M>T		No	ClinGen TOPMed
rs1238459718 CA384583910	283	R>G		No	ClinGen gnomAD
CA6512791 rs140268463	283	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6512792 rs140268463	283	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA384583903 rs1447901815	284	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA384583906 rs1555154443	284	G>S		No	ClinGen Ensembl
CA6512790 rs143860004	285	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs771403900 CA6512789	286	Q>K		No	ClinGen ExAC gnomAD
CA6512788 rs746576353	286	Q>R		No	ClinGen ExAC gnomAD
CA384583882 rs1324032291	287	T>N		No	ClinGen gnomAD
rs777156287 CA6512787	288	I>T		No	ClinGen ExAC gnomAD
rs1450097067 CA384583869	289	D>E		No	ClinGen TOPMed
CA384583840 rs1202382989	293	D>G		No	ClinGen gnomAD
CA6512786 rs757869795	297	N>S		No	ClinGen ExAC gnomAD
TCGA novel	298	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747782215 CA6512785	298	N>T		No	ClinGen ExAC gnomAD
CA235894459 rs375574046	299	I>T		No	ClinGen Ensembl
CA6512784 rs778592175	299	I>V		No	ClinGen ExAC gnomAD
rs754861906 CA6512783	305	E>Q		No	ClinGen ExAC gnomAD
CA235894457 rs994268394	306	V>A		No	ClinGen TOPMed gnomAD
rs753664588 CA6512782	306	V>F		No	ClinGen ExAC TOPMed gnomAD
rs753664588 CA235894458	306	V>L		No	ClinGen ExAC TOPMed gnomAD
CA235894456 rs1006092441	307	G>A		No	ClinGen Ensembl
CA384583738 rs1006092441	307	G>V		No	ClinGen Ensembl
CA6512781 rs149887227	308	S>L		No	ClinGen ESP ExAC gnomAD
rs1592312610 CA384583714	309	A>G		No	ClinGen Ensembl
rs779998613 CA6512755	310	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1259089546 CA384583704	311	P>H		No	ClinGen gnomAD
CA6512754 rs200179863	313	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1302351167 CA384583668	316	M>I		No	ClinGen TOPMed
CA235886221 rs919547321	318	S>N		No	ClinGen gnomAD
CA6512752 rs767448479	320	P>H		No	ClinGen ExAC gnomAD
CA384583643 rs1235738516	320	P>T		No	ClinGen gnomAD
CA235886220 rs758444290	321	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs758444290 CA6512751	321	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1378267915 CA384583638	321	P>S		No	ClinGen TOPMed
CA384583635 rs1361160986	322	T>A		No	ClinGen TOPMed gnomAD
rs201171876 CA6512748	323	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6512745 rs531725171 COSM1226233	323	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs531725171 CA6512746	323	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6512747 rs531725171	323	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs139087177 CA6512744	324	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6512742 rs761288225	326	L>S		No	ClinGen ExAC gnomAD
CA6512740 rs768216813	327	I>T		No	ClinGen ExAC gnomAD
rs748960640 CA6512739	328	V>L		No	ClinGen ExAC TOPMed gnomAD
CA235886218 rs201276691	330	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	331	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs543033286 CA6512738	331	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1458304953 CA384583576	333	Q>*		No	ClinGen Ensembl
rs745643692 CA6512737 CA6512736	334	M>I		No	ClinGen ExAC gnomAD
rs1188782251 CA384583569	334	M>V		No	ClinGen TOPMed
CA384583557 rs1279810761	335	F>L		No	ClinGen TOPMed gnomAD
CA6512734 rs749311925	338	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6512732 rs376729372	344	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1436116868 CA384583389	345	M>I		No	ClinGen TOPMed gnomAD
CA384583491 rs1341025595	345	M>K		No	ClinGen gnomAD
COSM1606049 CA384583352 rs1592227010	351	I>V	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	353	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1230669953 CA384583334	353	Q>H		No	ClinGen TOPMed
rs1251216065 CA384583326	354	M>I		No	ClinGen gnomAD
CA384583328 rs1459266193	354	M>T		No	ClinGen gnomAD
rs1276735694 CA384583293	359	D>V		No	ClinGen TOPMed
CA6512704 rs767939533	359	D>Y		No	ClinGen ExAC gnomAD
rs752141529 CA6512702	361	R>K		No	ClinGen ExAC gnomAD
rs764665031 CA6512701	363	A>G		No	ClinGen ExAC gnomAD
CA384583268 rs1555248252	363	A>S		No	ClinGen Ensembl
rs775123183 CA6512699	364	I>L		No	ClinGen ExAC TOPMed gnomAD
CA6512700 rs775123183	364	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	365	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764861666 CA6512698	365	W>R		No	ClinGen ExAC gnomAD
rs759229809 CA6512697	367	A>G		No	ClinGen ExAC gnomAD
CA384583242 rs1249364212	368	S>P		No	ClinGen TOPMed
CA6512695 rs770794073	369	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA384583204 rs1326060890	374	N>D		No	ClinGen gnomAD
CA6512692 rs531234541	377	F>S		No	ClinGen 1000Genomes ExAC gnomAD
CA235877442 rs889510880	378	T>R		No	ClinGen TOPMed gnomAD
rs780188266 CA6512690	379	L>F		No	ClinGen ExAC gnomAD
CA6512691 rs780188266	379	L>V		No	ClinGen ExAC gnomAD
rs146020551 CA6512688	380	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA235877441 rs867518967	381	G>E		No	ClinGen Ensembl
CA6512687 rs781230531	382	V>I		No	ClinGen ExAC TOPMed gnomAD
rs757735855 CA6512686	385	V>I		No	ClinGen ExAC gnomAD
CA6512685 rs751949518	388	V>A		No	ClinGen ExAC gnomAD
CA384583112 rs751949518	388	V>E		No	ClinGen ExAC gnomAD
CA384583111 rs751949518	388	V>G		No	ClinGen ExAC gnomAD
rs370937258 CA6512683	390	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6512682 rs753076022	390	R>H		No	ClinGen ExAC TOPMed gnomAD
CA384583062 rs1592226847	396	G>D		No	ClinGen Ensembl
rs1355375147 CA384583056	397	S>N		No	ClinGen gnomAD
rs764815128 CA6512681	399	A>T		No	ClinGen ExAC gnomAD
rs1216313817 CA384583020	401	T>S		No	ClinGen gnomAD
CA6512659 COSM1288000 rs200140895	402	T>A	autonomic_ganglia [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6512658 rs138153837	402	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6512656 rs372764299	403	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1168594723 CA384582999	405	L>F		No	ClinGen gnomAD
CA384582994 rs1430627052	406	I>V		No	ClinGen TOPMed
TCGA novel	407	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1490264846 CA384582929	416	A>T		No	ClinGen gnomAD
rs1235434094 CA384582926	416	A>V		No	ClinGen TOPMed
rs1302983116 CA384582924	417	Q>E		No	ClinGen TOPMed
rs761553310 CA6512653	417	Q>P		No	ClinGen ExAC gnomAD
rs774384915 CA6512652	419	S>A		No	ClinGen ExAC gnomAD
rs1253733676 CA384582908	419	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6512650 rs369402250	420	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6512649 rs776565219	421	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6512648 rs200242923	421	R>H		No	ClinGen ExAC TOPMed gnomAD
CA384582902 rs776565219	421	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6512646 rs778090097	422	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384582882 rs1320513149	424	F>S		No	ClinGen gnomAD
rs779536465 CA6512643	427	I>M		No	ClinGen ExAC gnomAD
CA6512644 rs748442743	427	I>T		No	ClinGen ExAC
CA384582849 rs1246071745	429	P>L		No	ClinGen TOPMed
TCGA novel	429	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754304967 CA6512641	431	G>D		No	ClinGen ExAC gnomAD
CA384582827 rs1329513929	433	N>H		No	ClinGen gnomAD
rs767124315 CA6512637	433	N>K		No	ClinGen ExAC gnomAD
CA6512639 rs563739300	433	N>S		No	ClinGen 1000Genomes ExAC
CA235876730 rs200572737	434	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6512636 rs200572737	434	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1463455434 CA384582814	435	T>I		No	ClinGen gnomAD
CA6512635 rs201928125	435	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA235876729 rs759666478	437	T>A		No	ClinGen Ensembl
rs1021602593 CA235873129	443	N>D		No	ClinGen TOPMed gnomAD
TCGA novel	445	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384582724 rs763806571	446	M>L		No	ClinGen ExAC TOPMed gnomAD
rs763806571 CA6512614	446	M>V		No	ClinGen ExAC TOPMed gnomAD
CA384582710 rs1266079792	448	D>N		No	ClinGen gnomAD
rs1345433900 CA384582689	450	D>E		No	ClinGen TOPMed
TCGA novel	451	C>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1210895129 CA384582687	451	C>R		No	ClinGen gnomAD
rs758160019 CA6512613	452	G>S		No	ClinGen ExAC gnomAD
TCGA novel	452	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	453	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA235873128 rs1010246332	458	N>D		No	ClinGen TOPMed
TCGA novel	460	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA235873127 rs891837078	461	T>S		No	ClinGen TOPMed gnomAD
CA384582605 rs1354650262	462	V>A		No	ClinGen gnomAD
CA384582586 rs1288382154	465	S>P		No	ClinGen gnomAD
rs1466223379 CA384582567	468	V>I		No	ClinGen TOPMed
rs1410788809 CA384582551	470	V>A		No	ClinGen gnomAD
CA384582546 rs1330539207	471	N>S		No	ClinGen gnomAD
CA384582537 rs1302078070	472	K>R		No	ClinGen gnomAD
rs1248739344 CA384582520	475	T>A		No	ClinGen TOPMed
rs752709836 CA6512612	475	T>I		No	ClinGen ExAC TOPMed gnomAD
CA384582518 rs752709836	475	T>K		No	ClinGen ExAC TOPMed gnomAD
rs1191300415 CA384582505	477	E>G		No	ClinGen TOPMed
CA6512611 rs765247341	477	E>K		No	ClinGen ExAC gnomAD
CA6512610 rs760898122	478	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1296094273 CA384582501	478	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA384582486 rs1360963734	480	W>S		No	ClinGen gnomAD
CA384398080 rs1374272284	485	N>D		No	ClinGen gnomAD
rs778864757 CA6512573	485	N>S		No	ClinGen ExAC gnomAD
CA384397980 rs1322090604	493	D>G		No	ClinGen gnomAD
CA384397969 rs1405303810	494	I>K		No	ClinGen TOPMed gnomAD
rs753861463 CA6512571	497	A>T		No	ClinGen ExAC TOPMed gnomAD
CA384397920 rs1438045829	498	Y>*	Variant assessed as Somatic; 4.627e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA384397927 rs780013367	498	Y>D		No	ClinGen ExAC TOPMed gnomAD
CA6512570 rs780013367	498	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs547975454 CA6512569	499	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA384397868 rs1179297513	503	T>A		No	ClinGen gnomAD
rs764286083 CA6512567	506	S>P		No	ClinGen ExAC gnomAD
CA6512565 rs763162394	508	T>N		No	ClinGen ExAC gnomAD
rs1163298497 CA384397799	509	A>G		No	ClinGen TOPMed
TCGA novel	509	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384397769 rs1224508852	513	L>V		No	ClinGen gnomAD
rs1224016985 CA384397737	516	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA384397723 rs777043798	517	L>F		No	ClinGen ExAC gnomAD
rs777043798 CA6512561	517	L>V		No	ClinGen ExAC gnomAD
rs1272575753 CA384397714	518	V>F		No	ClinGen gnomAD
rs1346754458 CA384397697	519	F>L		No	ClinGen gnomAD
rs529533390 CA6512560	519	F>Y		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	521	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	522	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1476802109 CA384397617	524	M>V		No	ClinGen gnomAD
rs767171759 CA6512539	526	P>R		No	ClinGen ExAC TOPMed gnomAD
rs773543569 CA6512540	526	P>S		No	ClinGen ExAC gnomAD
rs1407762648 CA384397573	527	M>V		No	ClinGen TOPMed
rs1235418681 CA384397494	530	T>I		No	ClinGen gnomAD
rs1406388193 COSM1361362 CA384397401	535	I>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA384397396 rs1468912300	536	Y>H		No	ClinGen TOPMed
CA6512537 rs774198949	540	A>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	541	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749102054 CA6512535	546	A>G		No	ClinGen ExAC gnomAD
rs768413141 CA6512536	546	A>S		No	ClinGen ExAC TOPMed gnomAD
rs768413141 CA235330388 COSM1586442	546	A>T	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs775357605 CA6512534	547	C>W		No	ClinGen ExAC gnomAD
CA6512533 rs150220364	549	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs745835876 CA6512532	551	I>V		No	ClinGen ExAC TOPMed gnomAD
rs781067627 CA6512531	556	N>K		No	ClinGen ExAC TOPMed gnomAD
CA384397051 rs1212910675	556	N>S		No	ClinGen TOPMed
rs1264535479 CA384397032	557	V>A		No	ClinGen TOPMed gnomAD
rs758512663 CA6512530	557	V>I		No	ClinGen ExAC gnomAD
CA6512528 rs779162216	561	L>P		No	ClinGen ExAC gnomAD
CA235330341 rs1034683373	565	H>Y		No	ClinGen TOPMed
CA6512527 rs755199353	566	T>I		No	ClinGen ExAC gnomAD
CA384396839 rs1430040053	569	Y>C		No	ClinGen TOPMed gnomAD
rs371762067 CA6512526	569	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	570	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384396819 rs1411382490	570	L>R		No	ClinGen gnomAD
rs1196264147 CA384396764	574	G>R		No	ClinGen gnomAD
CA384396525 rs1223748018	575	A>S		No	ClinGen gnomAD
CA384396529 rs1223748018	575	A>T		No	ClinGen gnomAD
CA384396504 rs1566754673	577	F>L		No	ClinGen Ensembl
rs752051614 CA6512498	579	Y>C		No	ClinGen ExAC gnomAD
rs1336363390 CA384396460	580	A>T		No	ClinGen gnomAD
rs147724845 CA6512496	580	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs780379358 CA235326932	583	A>V		No	ClinGen Ensembl
rs764773939 CA6512494	584	A>P		No	ClinGen ExAC TOPMed gnomAD
CA384396412 rs764773939	584	A>T		No	ClinGen ExAC TOPMed gnomAD
rs374629377 CA235326923	585	V>A		No	ClinGen ESP TOPMed gnomAD
CA384396399 rs776403918	585	V>L		No	ClinGen ExAC TOPMed gnomAD
CA6512492 rs776403918	585	V>M		No	ClinGen ExAC TOPMed gnomAD
rs370246586 CA6512491	587	L>I		No	ClinGen ESP ExAC gnomAD
rs1363873796 CA384396362	589	F>V		No	ClinGen gnomAD
rs1160729195 CA384396344	590	I>F		No	ClinGen gnomAD
rs768822331 CA6512488	592	G>A		No	ClinGen ExAC gnomAD
CA384396311 rs768822331	592	G>V		No	ClinGen ExAC gnomAD
rs1592109133 CA384396295	593	C>W		No	ClinGen Ensembl
rs1490928943 CA384396277	595	P>S		No	ClinGen gnomAD
rs749309444 CA6512487	597	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6512486 rs780384655	598	K>T		No	ClinGen ExAC gnomAD
CA6512485 CA384396222 rs769905519	601	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	601	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1311710474 CA384396170	605	I>M		No	ClinGen gnomAD
CA384396175 rs781699032	605	I>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	605	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6512483 rs781699032	605	I>T		No	ClinGen ExAC TOPMed gnomAD
rs746018116 CA6512484	605	I>V		No	ClinGen ExAC gnomAD
CA235326866 rs757643708	606	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1224066940 CA384396148	607	S>P		No	ClinGen gnomAD
CA384396133 rs1347091067	608	L>V		No	ClinGen gnomAD
rs1296189056 CA384396095	610	D>E		No	ClinGen gnomAD
CA384396073 rs1307711676	612	R>G		No	ClinGen gnomAD
rs757975939 CA6512479	616	C>F		No	ClinGen ExAC gnomAD
rs778111311 CA6512480	616	C>R		No	ClinGen ExAC gnomAD
CA6512478 rs752133778	617	G>D		No	ClinGen ExAC gnomAD
CA384395997 rs1592109058	618	T>A		No	ClinGen Ensembl
rs765005909 CA384395976	620	D>H		No	ClinGen ExAC gnomAD
CA6512477 rs765005909	620	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6512476 rs759202222	620	D>V		No	ClinGen ExAC gnomAD
CA384394984 rs1381229115	627	I>S		No	ClinGen gnomAD
CA384394910 rs1447767965	629	Y>*		No	ClinGen TOPMed gnomAD
CA384394878 rs1198972183	631	R>Q		No	ClinGen gnomAD
rs141841078 CA384394882 COSM1586443	631	R>W	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1263841013 CA384394810	635	S>N		No	ClinGen gnomAD
CA6512471 rs773186486	636	N>T		No	ClinGen ExAC gnomAD
rs771895007 CA6512470	637	Y>*		No	ClinGen ExAC gnomAD
rs763161899 CA384394768	638	H>P		No	ClinGen ExAC TOPMed gnomAD
CA6512469 rs763161899	638	H>R		No	ClinGen ExAC TOPMed gnomAD
CA235326791 rs918941302	642	N>D		No	ClinGen Ensembl
CA384394699 rs1566754116	642	N>S		No	ClinGen Ensembl
rs1407291378 CA384394665	644	A>S		No	ClinGen TOPMed
rs1407291378 CA384394669	644	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA384394657 rs1393941441	644	A>V		No	ClinGen gnomAD
rs1404633362 CA384394652	645	S>P		No	ClinGen gnomAD
rs769851596 CA6512467	648	E>G		No	ClinGen ExAC

No associated diseases with Q96QE2

3 regional properties for Q96QE2

Type	Name	Position	InterPro Accession
conserved_site	Sugar transporter, conserved site	180 - 205	IPR005829-1
conserved_site	Sugar transporter, conserved site	381 - 397	IPR005829-2
domain	Major facilitator superfamily domain	84 - 598	IPR020846

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
astrocyte end-foot	Terminal process of astrocyte abutting non-neuronal surfaces in the brain.
cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cell periphery	The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
cell projection	A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
organelle membrane	A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name	Definition
ATPase binding	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
myo-inositol transmembrane transporter activity	Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.
myo-inositol:proton symporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in).
protease binding	Binding to a protease or a peptidase.
transmembrane transporter activity	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

4 GO annotations of biological process

Name	Definition
myo-inositol transport	The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.
positive regulation of amyloid-beta formation	Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
transmembrane transport	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
transport across blood-brain barrier	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P30605	ITR1	Myo-inositol transporter 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P30606	ITR2	Myo-inositol transporter 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P58354	SLC2A8	Solute carrier family 2, facilitated glucose transporter member 8	Bos taurus (Bovine)	PR
Q9JIF3	Slc2a8	Solute carrier family 2, facilitated glucose transporter member 8	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSRKASENVE	YTLRSLSSLM	GERRRKQPEP	DAASAAGECS	LLAAAESSTS	LQSAGAGGGG
70	80	90	100	110	120
VGDLERAARR	QFQQDETPAF	VYVVAVFSAL	GGFLFGYDTG	VVSGAMLLLK	RQLSLDALWQ
130	140	150	160	170	180
ELLVSSTVGA	AAVSALAGGA	LNGVFGRRAA	ILLASALFTA	GSAVLAAANN	KETLLAGRLV
190	200	210	220	230	240
VGLGIGIASM	TVPVYIAEVS	PPNLRGRLVT	INTLFITGGQ	FFASVVDGAF	SYLQKDGWRY
250	260	270	280	290	300
MLGLAAVPAV	IQFFGFLFLP	ESPRWLIQKG	QTQKARRILS	QMRGNQTIDE	EYDSIKNNIE
310	320	330	340	350	360
EEEKEVGSAG	PVICRMLSYP	PTRRALIVGC	GLQMFQQLSG	INTIMYYSAT	ILQMSGVEDD
370	380	390	400	410	420
RLAIWLASVT	AFTNFIFTLV	GVWLVEKVGR	RKLTFGSLAG	TTVALIILAL	GFVLSAQVSP
430	440	450	460	470	480
RITFKPIAPS	GQNATCTRYS	YCNECMLDPD	CGFCYKMNKS	TVIDSSCVPV	NKASTNEAAW
490	500	510	520	530	540
GRCENETKFK	TEDIFWAYNF	CPTPYSWTAL	LGLILYLVFF	APGMGPMPWT	VNSEIYPLWA
550	560	570	580	590	600
RSTGNACSSG	INWIFNVLVS	LTFLHTAEYL	TYYGAFFLYA	GFAAVGLLFI	YGCLPETKGK
610	620	630	640
KLEEIESLFD	NRLCTCGTSD	SDEGRYIEYI	RVKGSNYHLS	DNDASDVE