P30606
Gene name |
ITR2 (YOL103W, HRB612) |
Protein name |
Myo-inositol transporter 2 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOL103W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30606
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30606-F1 | Predicted | AlphaFoldDB |
5 variants for P30606
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-124073 | 25 | N>D | No | SGRP | |
| s15-125350 | 450 | K>N | No | SGRP | |
| s15-125363 | 455 | D>N | No | SGRP | |
| s15-125400 | 467 | G>D | No | SGRP | |
| s15-125540 | 514 | A>T | No | SGRP |
No associated diseases with P30606
4 regional properties for P30606
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Sugar transporter, conserved site | 169 - 185 | IPR005829-1 |
| conserved_site | Sugar transporter, conserved site | 211 - 236 | IPR005829-2 |
| conserved_site | Sugar transporter, conserved site | 413 - 429 | IPR005829-3 |
| domain | Major facilitator superfamily domain | 112 - 558 | IPR020846 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| myo-inositol transmembrane transporter activity | Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. |
| myo-inositol:proton symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| myo-inositol import across plasma membrane | The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol. |
| myo-inositol transport | The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30605 | ITR1 | Myo-inositol transporter 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P43562 | YFL040W | Probable metabolite transport protein YFL040W | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q96QE2 | SLC2A13 | Proton myo-inositol cotransporter | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKNSTAASSR | WTKSRLSHFF | PSYTNSSGMG | AASTDQSSTQ | GEELHHRKHC | EEDNDGQKPK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSPVSTSTMQ | IKSRQDEDED | DGRIVIKPVN | DEDDTSVIIT | FNQSISPFII | TLTFVASISG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FMFGYDTGYI | SSALISINRD | LDNKVLTYGE | KELITAATSL | GALITSVGAG | TAADVFGRRP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CLMFSNLMFL | IGAILQITAH | KFWQMAAGRL | IMGFGVGIGS | LISPLFISEI | APKMIRGRLT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VINSLWLTGG | QLIAYGCGAG | LNHVKNGWRI | LVGLSLIPTV | LQFSFFCFLP | DTPRYYVMKG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DLKRAKMVLK | RSYVNTEDEI | IDQKVEELSS | LNQSIPGKNP | ITKFWNMVKE | LHTVPSNFRA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LIIGCGLQAI | QQFTGWNSLM | YFSGTIFETV | GFKNSSAVSI | IVSGTNFVFT | LIAFFCIDKI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GRRYILLIGL | PGMTVALVIC | AIAFHFLGIK | FNGADAVVAS | DGFSSWGIVI | IVFIIVYAAF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YALGIGTVPW | QQSELFPQNV | RGVGTSYATA | TNWAGSLVIA | STFLTMLQNI | TPTGTFSFFA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GVACLSTIFC | YFCYPELSGL | ELEEVQTILK | DGFNIKASKA | LAKKRKQQVA | EGAAHHKLKF |
| EPTQEIVES |