P30605

PR
Gene name
ITR1 (YDR497C, D9719.3)
Protein name
Myo-inositol transporter 1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR497C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P30605

Entry ID Method Resolution Chain Position Source
AF-P30605-F1 Predicted AlphaFoldDB

5 variants for P30605

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1444669 264 C>Y No SGRP
s04-1444492 323 N>S No SGRP
s04-1444436 342 C>S No SGRP
s04-1443898 521 C>F No SGRP
s04-1443770 564 Q>E No SGRP

No associated diseases with P30605

4 regional properties for P30605

Type Name Position InterPro Accession
conserved_site Sugar transporter, conserved site 146 - 162 IPR005829-1
conserved_site Sugar transporter, conserved site 188 - 213 IPR005829-2
conserved_site Sugar transporter, conserved site 390 - 406 IPR005829-3
domain Major facilitator superfamily domain 89 - 535 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Localizes to the cell membrane in conditions of low inositol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
myo-inositol transmembrane transporter activity Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.
myo-inositol:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in).
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

4 GO annotations of biological process

Name Definition
myo-inositol import across plasma membrane The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol.
myo-inositol transport The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.
pseudohyphal growth The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43562 YFL040W Probable metabolite transport protein YFL040W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P30606 ITR2 Myo-inositol transporter 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q96QE2 SLC2A13 Proton myo-inositol cotransporter Homo sapiens (Human) PR
10 20 30 40 50 60
MGIHIPYLTS KTSQSNVGDA VGNADSVEFN SEHDSPSKRG KITLESHEIQ RAPASDDEDR
70 80 90 100 110 120
IQIKPVNDED DTSVMITFNQ SLSPFIITLT FVASISGFMF GYDTGYISSA LISIGTDLDH
130 140 150 160 170 180
KVLTYGEKEI VTAATSLGAL ITSIFAGTAA DIFGRKRCLM GSNLMFVIGA ILQVSAHTFW
190 200 210 220 230 240
QMAVGRLIMG FGVGIGSLIA PLFISEIAPK MIRGRLTVIN SLWLTGGQLV AYGCGAGLNY
250 260 270 280 290 300
VNNGWRILVG LSLIPTAVQF TCLCFLPDTP RYYVMKGDLA RATEVLKRSY TDTSEEIIER
310 320 330 340 350 360
KVEELVTLNQ SIPGKNVPEK VWNTIKELHT VPSNLRALII GCGLQAIQQF TGWNSLMYFS
370 380 390 400 410 420
GTIFETVGFK NSSAVSIIVS GTNFIFTLVA FFSIDKIGRR TILLIGLPGM TMALVVCSIA
430 440 450 460 470 480
FHFLGIKFDG AVAVVVSSGF SSWGIVIIVF IIVFAAFYAL GIGTVPWQQS ELFPQNVRGI
490 500 510 520 530 540
GTSYATATNW AGSLVIASTF LTMLQNITPA GTFAFFAGLS CLSTIFCYFC YPELSGLELE
550 560 570 580
EVQTILKDGF NIKASKALAK KRKQQVARVH ELKYEPTQEI IEDI