P58354

PR
Gene name
SLC2A8
Protein name
Solute carrier family 2, facilitated glucose transporter member 8
Names
Glucose transporter type 8, GLUT-8, Glucose transporter type X1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282867
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58354

Entry ID Method Resolution Chain Position Source
AF-P58354-F1 Predicted AlphaFoldDB

No variants for P58354

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P58354

No associated diseases with P58354

2 regional properties for P58354

Type Name Position InterPro Accession
domain Potassium channel tetramerisation-type BTB domain 14 - 98 IPR003131
domain BTB/POZ domain-containing protein KCTD18, C-terminal domain 114 - 425 IPR045704

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle membrane ; Multi-pass membrane protein
  • Principally intracellular
  • May move between intracellular vesicles and the plasma membrane
  • The dileucine internalization motif is critical for intracellular sequestration
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
dehydroascorbic acid transmembrane transporter activity Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.
fructose transmembrane transporter activity Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
glucose transmembrane transporter activity Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.

3 GO annotations of biological process

Name Definition
dehydroascorbic acid transport The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.
fructose transmembrane transport The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
glucose transmembrane transport The process in which glucose is transported across a membrane.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96QE2 SLC2A13 Proton myo-inositol cotransporter Homo sapiens (Human) PR
Q9JIF3 Slc2a8 Solute carrier family 2, facilitated glucose transporter member 8 Mus musculus (Mouse) PR
10 20 30 40 50 60
MTPEDQEETQ PLLRPPGGSA PRGRRVFLAA FAAALGPLSF GFALGYSSPA IPSLRRAAPP
70 80 90 100 110 120
APHLDEDAAS WFGAIVTLGA AAGGVLGGWL LDRAGRKLSL VLCALPFVAG FAVITAAQNL
130 140 150 160 170 180
WMLLGGRLLT GLACGIASLV APVYISEIAY PEVRGLLGSC VQLMVVTGIL LAYLAGWVLE
190 200 210 220 230 240
WRWLAVLGCV PPSFMLLLMC FMPETPRFLL SQHKHQEAMA AMQFLWGYAQ GWEEPPLGAQ
250 260 270 280 290 300
HQDFHVAQLR RPGVYKPFII GISLMAFQQL SGVNAVMFYA ETIFEEAKFK DSSLASVVVG
310 320 330 340 350 360
VIQVLFTATA ALIMDRAGRR LLLTLSGVVM VFSTSAFGTY FKLTEGGPSN SSHVDLPALV
370 380 390 400 410 420
SMEAADTNVG LAWLAVGSMC LFIAGFAVGW GPIPWLLMSE IFPLHVKGVA TGVCVLTNWF
430 440 450 460 470
MAFLVTKEFS SLMEVLRPYG AFWLASAFCI FGVLFTLACV PETKGKTLEQ ITAHFEGR