AiPD: Autoinhibited Protein Database

Q96MN5

Gene name	TCEANC2 (C1orf83)
Protein name	Transcription elongation factor A N-terminal and central domain-containing protein 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:127428
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

84-159 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

84-159 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96MN5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96MN5-F1	Predicted				AlphaFoldDB

191 variants for Q96MN5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1048484677 CA22698736	2	D>V		No	ClinGen TOPMed
rs1255850946 CA340436389	3	K>E		No	ClinGen gnomAD
COSM1296581 CA340436423 rs1329527200	4	F>L	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA340436434 rs1302829685	5	V>I		No	ClinGen TOPMed
CA863828 rs778936595	7	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	7	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340436515 rs1487205267	9	P>R		No	ClinGen gnomAD
rs142194812 CA863830	9	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA22698742 COSM910842 rs968953779	10	R>G	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs138552479 CA863831	11	I>T		No	ClinGen ESP ExAC TOPMed
rs1261988330 CA340436578	12	Q>*		No	ClinGen gnomAD
rs771348032 CA863833	13	N>H		No	ClinGen ExAC gnomAD
CA863834 rs774965287	14	S>G		No	ClinGen ExAC TOPMed gnomAD
rs762634160 CA863835	14	S>R		No	ClinGen ExAC gnomAD
rs768240665 CA863836	15	P>L		No	ClinGen ExAC gnomAD
rs773982649 COSM1198474 CA863838	17	K>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	18	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767491126 CA863840	21	G>E		No	ClinGen ExAC gnomAD
rs1362771825 CA340436780	22	G>A		No	ClinGen TOPMed gnomAD
rs959926412 CA22698791	23	K>N		No	ClinGen Ensembl
rs992728241 CA22698792	24	V>I		No	ClinGen TOPMed
CA340436798 rs992728241	24	V>L		No	ClinGen TOPMed
rs143447897 CA22698804	25	Y>C		No	ClinGen ESP ExAC gnomAD
rs143447897 CA863843	25	Y>F		No	ClinGen ESP ExAC gnomAD
rs760342468 CA863842	25	Y>H		No	ClinGen ExAC gnomAD
CA863845 rs142262266	27	Q>R		No	ClinGen ESP ExAC gnomAD
rs758477995 CA863848	28	A>G		No	ClinGen ExAC TOPMed gnomAD
CA22698845 rs752770321	28	A>P		No	ClinGen ExAC gnomAD
rs752770321 CA863847	28	A>T		No	ClinGen ExAC gnomAD
rs1485277681 CA340436877	29	T>K		No	ClinGen gnomAD
CA863850 rs201738154	30	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA340423610 rs1042704692	36	V>A		No	ClinGen TOPMed gnomAD
CA22678835 rs1042704692	36	V>D		No	ClinGen TOPMed gnomAD
CA340423615 rs1482496724	37	V>E		No	ClinGen gnomAD
CA863865 rs758430968	38	V>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	40	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	40	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA22678841 rs375590073	41	D>G		No	ClinGen Ensembl
rs764125137 CA863866	41	D>N		No	ClinGen ExAC gnomAD
rs1557688058 CA340423646	42	I>K		No	ClinGen Ensembl
CA340423649 rs1439128451	42	I>M		No	ClinGen gnomAD
CA340423647 rs1557688058	42	I>T		No	ClinGen Ensembl
CA340423644 rs1557688056	42	I>V		No	ClinGen Ensembl
rs1156998967 CA340423658	44	R>G		No	ClinGen gnomAD
rs1397102786 CA340423668	45	W>*		No	ClinGen gnomAD
rs1246848271 CA340423673	45	W>C		No	ClinGen gnomAD
TCGA novel	46	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340423686 rs150639315	47	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA863867 rs150639315	47	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150639315 CA340423685	47	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340423692 rs1357164956	48	M>I		No	ClinGen gnomAD
rs757767731 CA863868	48	M>T		No	ClinGen ExAC gnomAD
rs1570000349 CA340423688 COSM3741314 COSM3741315	48	M>V	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
CA863870 rs746174983	53	D>G		No	ClinGen ExAC gnomAD
rs781611589 CA863869	53	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1408193112 CA340423726	54	Q>K		No	ClinGen TOPMed
CA863872 rs144986013	56	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA22678897 rs767886928	56	K>R		No	ClinGen Ensembl
rs747836005 CA863873	57	E>G		No	ClinGen ExAC
rs1233053422 CA340423754	58	N>D		No	ClinGen gnomAD
TCGA novel	59	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771896032 CA863874	60	V>A		No	ClinGen ExAC gnomAD
rs1186967243 CA340423767	60	V>I		No	ClinGen TOPMed
rs772759970 CA863875	62	A>D		No	ClinGen ExAC TOPMed gnomAD
rs772759970 CA863877	62	A>G		No	ClinGen ExAC TOPMed gnomAD
CA340423782 rs1310782581	62	A>S		No	ClinGen gnomAD
CA863876 rs772759970	62	A>V		No	ClinGen ExAC TOPMed gnomAD
CA340423790 rs1233959620	64	Q>*		No	ClinGen gnomAD
CA340423800 rs1457754357	65	E>*		No	ClinGen TOPMed gnomAD
CA340423798 rs1457754357	65	E>K		No	ClinGen TOPMed gnomAD
CA340423825 rs1490239286	68	K>R		No	ClinGen TOPMed
CA22678922 rs1040831141	70	I>T		No	ClinGen TOPMed gnomAD
CA340423839 rs1266185201	70	I>V		No	ClinGen TOPMed
TCGA novel	70	I>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM681748 CA863878 rs776439131	71	P>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs776439131 CA340423843	71	P>T		No	ClinGen ExAC TOPMed gnomAD
rs759270050 CA863879	72	S>F		No	ClinGen ExAC TOPMed
TCGA novel	77	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340423905 rs1445124509	80	R>K		No	ClinGen TOPMed gnomAD
CA340423915 rs1411447380	81	I>M		No	ClinGen gnomAD
CA340423918 rs1345750794	82	G>R		No	ClinGen TOPMed
rs762802716 CA863902	84	T>I		No	ClinGen ExAC TOPMed gnomAD
CA340426098 rs762802716	84	T>S		No	ClinGen ExAC TOPMed gnomAD
CA863904 rs774445232	88	M>V		No	ClinGen ExAC gnomAD
rs370305122 CA863905	89	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA863906 rs76384967	89	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA863907 rs76384967	89	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340426131 rs370305122	89	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1448844156 CA340426144	91	H>P		No	ClinGen gnomAD
CA340426148 rs1216703226	91	H>Q		No	ClinGen gnomAD
CA340426141 rs1315830143	91	H>Y		No	ClinGen TOPMed
CA863908 rs761245920	94	S>L		No	ClinGen ExAC gnomAD
CA863910 rs767055319	98	S>F		No	ClinGen ExAC TOPMed gnomAD
CA863911 rs142157986	99	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA340426204 rs1472393742	101	R>G		No	ClinGen gnomAD
CA863912 rs755398648	102	E>Q		No	ClinGen ExAC gnomAD
CA340426223 rs1409482362	103	V>G		No	ClinGen gnomAD
CA863914 rs751194630	106	E>D		No	ClinGen ExAC gnomAD
rs41294784 CA863913	106	E>K		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA22692987 rs41294784	106	E>Q		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA340426243 rs1314951541	107	W>G		No	ClinGen gnomAD
rs867737674 CA22693009	109	T>N		No	ClinGen Ensembl
CA22693027 rs1041676863	110	F>S		No	ClinGen TOPMed gnomAD
CA22693049 rs756973311	116	N>D		No	ClinGen ExAC TOPMed gnomAD
CA863915 rs756973311	116	N>H		No	ClinGen ExAC TOPMed gnomAD
CA22693057 rs780543399	116	N>S		No	ClinGen ExAC TOPMed gnomAD
CA863916 rs780543399	116	N>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	117	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340426314 rs1244644782	117	R>K		No	ClinGen gnomAD
CA340426322 rs1282963558	118	P>H		No	ClinGen TOPMed gnomAD
rs200057608 CA863918	120	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA863917 rs745440627	120	I>V		No	ClinGen ExAC TOPMed gnomAD
CA340426342 rs1271041773	121	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1285578781 CA340426353	123	R>T		No	ClinGen gnomAD
CA340426357 rs1487465672	124	S>G		No	ClinGen gnomAD
rs768355168 CA863921	129	E>K		No	ClinGen ExAC TOPMed gnomAD
CA863922 rs142956141	130	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1157586491 CA340426412	132	R>G		No	ClinGen gnomAD
rs904579301 CA22693092	132	R>K		No	ClinGen Ensembl
rs773416554 CA863925	134	N>S		No	ClinGen ExAC TOPMed gnomAD
rs760908241 CA863926	138	L>*		No	ClinGen ExAC gnomAD
CA340426475 rs1395856006	140	S>L		No	ClinGen gnomAD
rs1332741177 CA340426493	142	A>T		No	ClinGen gnomAD
rs1447596860 CA340426519	144	E>K		No	ClinGen gnomAD
rs1162154208 CA340427795	147	M>K		No	ClinGen TOPMed
CA340427818 rs1444544768	148	D>E		No	ClinGen TOPMed
CA340427804 rs1557695152	148	D>N		No	ClinGen Ensembl
CA22698718 rs913218545	149	H>D		No	ClinGen Ensembl
rs771158515 CA863948	149	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA340427854 rs1474494686	152	V>G		No	ClinGen TOPMed
CA863949 rs759937568	152	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	153	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340427893 rs1252778212	155	I>T		No	ClinGen gnomAD
rs775713693 CA863951	156	E>G		No	ClinGen ExAC gnomAD
CA863950 rs370725438	156	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA863953 rs767095722	157	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA863952 rs763379829	157	R>W		No	ClinGen ExAC gnomAD
rs1266221149 CA340427930	158	E>D		No	ClinGen gnomAD
CA863954 rs750094338	158	E>V		No	ClinGen ExAC gnomAD
rs965951920 CA22698762	159	T>M		No	ClinGen TOPMed
CA22698785 rs997728832	160	F>I		No	ClinGen TOPMed gnomAD
CA863957 rs753440249	161	H>R		No	ClinGen ExAC gnomAD
rs1170566448 CA340427981	162	L>P		No	ClinGen gnomAD
CA22698821 rs529952234	162	L>V		No	ClinGen 1000Genomes gnomAD
TCGA novel	163	C>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA863959 rs41294786 COSM681747	164	S>C	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA863960 rs41294786	164	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA863961 rs147217795	165	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs758227253 CA863962	165	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1385265269 CA340428004	166	L>P		No	ClinGen gnomAD
rs567002853 CA22698889	167	I>N		No	ClinGen 1000Genomes TOPMed gnomAD
CA863966 rs771321590	170	P>L		No	ClinGen ExAC TOPMed gnomAD
rs747267844 CA863965	170	P>S		No	ClinGen ExAC gnomAD
CA22698899 rs201915019	171	Y>H		No	ClinGen Ensembl
rs774935013 CA22698920	172	R>P		No	ClinGen ExAC gnomAD
CA863968 rs774935013	172	R>Q		No	ClinGen ExAC gnomAD
CA863967 rs150173822	172	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA863970 rs762443594	173	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA863969 rs770131308 COSM1198473	173	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs371890157 CA340428042	174	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs764470272 CA863972	174	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs371890157 CA863971	174	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1570026646 CA340428051	175	V>G		No	ClinGen Ensembl
rs1426003446 CA340428062	177	A>V		No	ClinGen gnomAD
CA863974 rs774735168	178	L>P		No	ClinGen ExAC gnomAD
rs1570026673 CA340428074	179	V>G		No	ClinGen Ensembl
CA340428071 rs1367913849	179	V>L		No	ClinGen gnomAD
rs1290817496 CA340428093	182	L>*		No	ClinGen TOPMed gnomAD
rs1290817496 CA340428092	182	L>S		No	ClinGen TOPMed gnomAD
rs1399154523 CA340428110	184	H>Q		No	ClinGen gnomAD
CA863977 rs569179457	185	R>*		No	ClinGen 1000Genomes ExAC gnomAD
rs765027682 CA340428114	185	R>L		No	ClinGen ExAC gnomAD
COSM910846 rs765027682 CA863979	185	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA863980 rs538127698	186	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1194585344 CA340428125	187	E>V		No	ClinGen TOPMed
rs1046518851 CA22699015	188	I>T		No	ClinGen TOPMed
CA863983 rs374584308	189	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs777682264 CA863982	189	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	191	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA863985 rs781481333	192	V>G		No	ClinGen ExAC gnomAD
rs1248340918 CA340428193	193	K>R		No	ClinGen TOPMed
rs745878111 CA863986	195	G>S		No	ClinGen ExAC gnomAD
CA863987 rs769935527	196	S>L		No	ClinGen ExAC TOPMed gnomAD
CA340428229 rs1182923673	196	S>P		No	ClinGen gnomAD
rs769935527 CA863988	196	S>W		No	ClinGen ExAC TOPMed gnomAD
CA340428246 rs1570026835	197	L>P		No	ClinGen Ensembl
CA340428277 rs1557695259	200	G>R		No	ClinGen Ensembl
rs762234407 CA863992	201	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs764835560 CA863996	207	K>Q		No	ClinGen ExAC gnomAD
rs1393079767 CA340428380	207	K>R		No	ClinGen TOPMed gnomAD
rs370390913 CA863997	208	K>E		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q96MN5

3 regional properties for Q96MN5

Type	Name	Position	InterPro Accession
domain	Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type	38 - 113	IPR003617
domain	Transcription elongation factor S-II, central domain	131 - 208	IPR003618
domain	Transcription factor IIS, N-terminal	40 - 114	IPR017923

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name	Definition
DNA-templated transcription	The synthesis of an RNA transcript from a DNA template.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A5PKE4	TCEANC2	Transcription elongation factor A N-terminal and central domain-containing protein 2	Bos taurus (Bovine)	PR
P23193	TCEA1	Transcription elongation factor A protein 1	Homo sapiens (Human)	PR
P23881	Tcea3	Transcription elongation factor A protein 3	Mus musculus (Mouse)	PR
P10711	Tcea1	Transcription elongation factor A protein 1	Mus musculus (Mouse)	PR
Q8R2M0	Tceanc2	Transcription elongation factor A N-terminal and central domain-containing protein 2	Mus musculus (Mouse)	PR
Q5XIC7	Tceanc2	Transcription elongation factor A N-terminal and central domain-containing protein 2	Rattus norvegicus (Rat)	PR
P52652	T24H10.1	Putative transcription elongation factor S-II	Caenorhabditis elegans	PR

10	20	30	40	50	60
MDKFVIRTPR	IQNSPQKKDS	GGKVYKQATI	ESLKRVVVVE	DIKRWKTMLE	LPDQTKENLV
70	80	90	100	110	120
EALQELKKKI	PSREVLKSTR	IGHTVNKMRK	HSDSEVASLA	REVYTEWKTF	TEKHSNRPSI
130	140	150	160	170	180
EVRSDPKTES	LRKNAQKLLS	EALELKMDHL	LVENIERETF	HLCSRLINGP	YRRTVRALVF
190	200
TLKHRAEIRA	QVKSGSLPVG	TFVQTHKK