P23881
Gene name |
Tcea3 (Tfiish) |
Protein name |
Transcription elongation factor A protein 3 |
Names |
Transcription elongation factor S-II protein 3, Transcription elongation factor TFIIS.h |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21401 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P23881
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1WJT | NMR | - | A | 1-90 | PDB |
| AF-P23881-F1 | Predicted | AlphaFoldDB |
27 variants for P23881
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs233948765 | 19 | S>A | No | EVA | |
| rs3394953406 | 25 | G>E | No | EVA | |
| rs3394981577 | 28 | D>G | No | EVA | |
| rs3388720318 | 35 | S>R | No | EVA | |
| rs3388722992 | 50 | V>M | No | EVA | |
| rs3388723451 | 81 | S>Y | No | EVA | |
| rs3388720307 | 105 | D>G | No | EVA | |
| rs3388722587 | 120 | G>W | No | EVA | |
| rs259640461 | 135 | S>F | No | EVA | |
| rs219814692 | 149 | N>D | No | EVA | |
| rs3388720693 | 157 | T>I | No | EVA | |
| rs239949897 | 157 | T>P | No | EVA | |
| rs3388720729 | 163 | S>I | No | EVA | |
| rs3388725501 | 165 | S>* | No | EVA | |
| rs3388715733 | 166 | T>I | No | EVA | |
| rs3388722560 | 166 | T>P | No | EVA | |
| rs3388722560 | 166 | T>S | No | EVA | |
| rs3388720725 | 167 | P>H | No | EVA | |
| rs241859421 | 170 | A>T | No | EVA | |
| rs3388727756 | 178 | P>L | No | EVA | |
| rs3412942377 | 214 | L>M | No | EVA | |
| rs3388724557 | 252 | L>Q | No | EVA | |
| rs3388710136 | 254 | R>L | No | EVA | |
| rs3388722532 | 295 | Q>K | No | EVA | |
| rs3394908899 | 306 | L>H | No | EVA | |
| rs3388718178 | 326 | S>C | No | EVA | |
| rs3388722599 | 338 | N>Y | No | EVA |
No associated diseases with P23881
1 regional properties for P23881
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 9 - 173 | IPR005225 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
| transcription elongation by RNA polymerase II promoter | The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PKE4 | TCEANC2 | Transcription elongation factor A N-terminal and central domain-containing protein 2 | Bos taurus (Bovine) | PR |
| Q96MN5 | TCEANC2 | Transcription elongation factor A N-terminal and central domain-containing protein 2 | Homo sapiens (Human) | PR |
| P23193 | TCEA1 | Transcription elongation factor A protein 1 | Homo sapiens (Human) | PR |
| Q8R2M0 | Tceanc2 | Transcription elongation factor A N-terminal and central domain-containing protein 2 | Mus musculus (Mouse) | PR |
| P10711 | Tcea1 | Transcription elongation factor A protein 1 | Mus musculus (Mouse) | PR |
| Q5XIC7 | Tceanc2 | Transcription elongation factor A N-terminal and central domain-containing protein 2 | Rattus norvegicus (Rat) | PR |
| P52652 | T24H10.1 | Putative transcription elongation factor S-II | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLEEELLRI | AKKLEKMVSR | KKTEGALDLL | KKLNSCQMSI | QLLQTTRIGV | AVNGVRKHCS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DKEVVSLAKV | LIKNWKRLLD | SPRTTKGERE | EREKAKKEKG | LGCSDWKPEA | GLSPPRKKGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEPKTRRDSV | DSRSSTTSSP | KRPSLERSNS | SKSKVETPTT | PSSPSTPTFA | PAVCLLAPCY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LTGDSVRDKC | VEMLSAALKA | EDNFKDYGVN | CDKLASEIED | HIYQELKSTD | MKYRNRVRSR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISNLKDPRNP | GLRRNVLSGA | ISPELIAKMT | AEEMASDELR | ELRNAMTQEA | IREHQMAKTG |
| 310 | 320 | 330 | 340 | ||
| GTTTDLLRCS | KCKKKNCTYN | QVQTRSADEP | MTTFVLCNEC | GNRWKFC |