P10711

PR
Gene name
Tcea1 (Tceat)
Protein name
Transcription elongation factor A protein 1
Names
Transcription elongation factor S-II protein 1, Transcription elongation factor TFIIS.o
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:21399
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-136 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P10711

Entry ID Method Resolution Chain Position Source
AF-P10711-F1 Predicted AlphaFoldDB

14 variants for P10711

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388456813 25 L>F No EVA
rs3388457127 25 L>S No EVA
rs3389602789 46 I>T No EVA
rs3388456483 60 E>V No EVA
rs3388457190 67 K>R No EVA
rs3388456150 70 I>V No EVA
rs3388456358 76 L>F No EVA
rs3388456769 202 K>R No EVA
rs3388456404 254 G>S No EVA
rs3388457405 286 T>R No EVA
rs3389598086 288 F>I No EVA
rs3389576699 288 F>Y No EVA
rs3388456230 296 N>K No EVA
rs3388456229 302 C>R No EVA

No associated diseases with P10711

4 regional properties for P10711

Type Name Position InterPro Accession
domain Zinc finger, TFIIS-type 259 - 300 IPR001222
domain Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type 5 - 79 IPR003617
domain Transcription elongation factor S-II, central domain 136 - 256 IPR003618
domain Transcription factor IIS, N-terminal 3 - 80 IPR017923

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PKE4 TCEANC2 Transcription elongation factor A N-terminal and central domain-containing protein 2 Bos taurus (Bovine) PR
Q96MN5 TCEANC2 Transcription elongation factor A N-terminal and central domain-containing protein 2 Homo sapiens (Human) PR
P23193 TCEA1 Transcription elongation factor A protein 1 Homo sapiens (Human) PR
Q8R2M0 Tceanc2 Transcription elongation factor A N-terminal and central domain-containing protein 2 Mus musculus (Mouse) PR
P23881 Tcea3 Transcription elongation factor A protein 3 Mus musculus (Mouse) PR
Q5XIC7 Tceanc2 Transcription elongation factor A N-terminal and central domain-containing protein 2 Rattus norvegicus (Rat) PR
P52652 T24H10.1 Putative transcription elongation factor S-II Caenorhabditis elegans PR
10 20 30 40 50 60
MEDEVVRIAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV NALRKQSTDE
70 80 90 100 110 120
EVTSLAKSLI KSWKKLLDGP STDKDPEEKK KEPAISSQNS PEAREESSSS SNVSSRKDET
130 140 150 160 170 180
NARDTYVSSF PRAPSTSDSV RLKCREMLAA ALRTGDDYVA IGADEEELGS QIEEAIYQEI
190 200 210 220 230 240
RNTDMKYKNR VRSRISNLKD AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL
250 260 270 280 290 300
TKEAIREHQM AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF
C