AiPD: Autoinhibited Protein Database

Q96CS3

Gene name	FAF2 (ETEA, KIAA0887, UBXD8, UBXN3B)
Protein name	FAS-associated factor 2
Names	Protein ETEA, UBX domain-containing protein 3B, UBX domain-containing protein 8
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23197
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-113 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

29-113 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q96CS3

Entry ID	Method	Resolution	Chain	Position	Source
2DAM	NMR	-	A	3-56	PDB
AF-Q96CS3-F1	Predicted				AlphaFoldDB

237 variants for Q96CS3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3568963 rs776471303	3	A>V		No	ClinGen ExAC gnomAD
rs983347112 CA131850646	4	P>L		No	ClinGen TOPMed gnomAD
CA362252604 rs1390137958	4	P>S		No	ClinGen TOPMed gnomAD
rs907645195 CA131850679	5	E>A		No	ClinGen TOPMed gnomAD
rs184408647 CA3568966 COSM3827722	5	E>Q	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA362252613 rs1485168165	6	E>K		No	ClinGen TOPMed
CA131850684 rs1039105017	7	R>L		No	ClinGen TOPMed gnomAD
rs754985150 CA3568967	7	R>W		No	ClinGen ExAC gnomAD
rs767687577 CA3568968	8	D>A		No	ClinGen ExAC TOPMed gnomAD
CA362252624 rs1235943809	8	D>N		No	ClinGen TOPMed
rs767687577 CA3568969	8	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1235943809 CA362252626	8	D>Y		No	ClinGen TOPMed
CA3568971 rs778429472	14	T>I		No	ClinGen ExAC gnomAD
CA362252669 rs778429472	14	T>R		No	ClinGen ExAC gnomAD
TCGA novel	15	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA131838103 rs939662951	23	L>F		No	ClinGen Ensembl
CA362252409 rs1363891196	24	T>A		No	ClinGen gnomAD
CA362252443 rs1219868986	29	M>V		No	ClinGen TOPMed
rs1305619269 CA362252464	31	Q>L		No	ClinGen gnomAD
rs1397413497 CA362252477	33	R>C		No	ClinGen TOPMed gnomAD
rs757529894 CA3568990	33	R>H		No	ClinGen ExAC gnomAD
rs757529894 CA362252479	33	R>L		No	ClinGen ExAC gnomAD
rs199533667 CA131838112	41	W>R		No	ClinGen 1000Genomes
CA131838120 rs112214756	42	N>S		No	ClinGen 1000Genomes
CA362253680 rs1255000033	47	V>A		No	ClinGen gnomAD
rs1476857030 CA362253775	53	E>Q		No	ClinGen TOPMed
rs540774262 CA3569014	54	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA3569015 rs377291257	55	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	55	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362253830 rs1461643391	56	G>A		No	ClinGen gnomAD
CA131843320 rs745836730	56	G>S		No	ClinGen Ensembl
rs568519297 CA3569016	57	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1207051339 CA362253863	59	S>T		No	ClinGen TOPMed
TCGA novel	60	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369828433 CA3569017	62	N>S		No	ClinGen ESP ExAC gnomAD
CA3569019 rs756015233	63	P>R		No	ClinGen ExAC gnomAD
rs748033981 CA362253912	63	P>S		No	ClinGen ExAC gnomAD
rs748033981 CA3569018	63	P>T		No	ClinGen ExAC gnomAD
CA3569020 rs373205789	65	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	65	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3569021 rs749063074	67	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3569022 rs770880318	68	P>L		No	ClinGen ExAC gnomAD
CA362253937 rs887334059	68	P>S		No	ClinGen TOPMed gnomAD
CA131843349 rs887334059	68	P>T		No	ClinGen TOPMed gnomAD
rs376132848 CA3569023	71	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	72	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362254003 rs1252469805	75	D>G		No	ClinGen TOPMed gnomAD
CA3569024 rs747282337	76	H>Y		No	ClinGen ExAC gnomAD
rs1180564744 CA362254036	77	R>S		No	ClinGen gnomAD
rs1251584875 CA362254112	83	V>G		No	ClinGen gnomAD
CA131843368 rs1048151912	88	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA362254172 rs1475711354	88	P>S		No	ClinGen gnomAD
rs1421057704 CA362254480	94	W>C		No	ClinGen gnomAD
CA3569039 rs749223653	94	W>S		No	ClinGen ExAC gnomAD
TCGA novel	96	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3569040 rs757095949	97	Y>C		No	ClinGen ExAC gnomAD
rs1188129424 CA362254507	98	L>F		No	ClinGen TOPMed
rs148685647 CA3569042	101	L>F		No	ClinGen ESP ExAC gnomAD
CA362254531 rs1436420854	102	P>A		No	ClinGen gnomAD
CA3569043 rs768929958	103	F>L		No	ClinGen ExAC gnomAD
CA362254545 rs1447612657	104	R>Q		No	ClinGen TOPMed gnomAD
CA362254544 rs1358292679	104	R>W		No	ClinGen gnomAD
CA362254560 rs889775618	106	T>I		No	ClinGen TOPMed gnomAD
CA131844974 rs889775618	106	T>S		No	ClinGen TOPMed gnomAD
CA131844987 rs201122100	108	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA3569045 rs201122100	108	Y>S		No	ClinGen 1000Genomes ExAC gnomAD
rs769791069 CA3569046	109	T>M		No	ClinGen ExAC TOPMed gnomAD
CA362254581 rs1237062771	110	I>V		No	ClinGen TOPMed gnomAD
rs766728205 CA3569049	112	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs896183293 CA131845031	112	D>V		No	ClinGen Ensembl
CA3569050 rs774634955	113	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1253115470 CA362254989	115	R>S		No	ClinGen TOPMed gnomAD
CA3569068 rs759854470	117	A>V		No	ClinGen ExAC gnomAD
CA362255021 rs1196731224	118	L>V		No	ClinGen gnomAD
rs151193681 CA3569069	119	R>C		No	ClinGen ESP ExAC gnomAD
CA3569070 rs775185443	121	I>M		No	ClinGen ExAC gnomAD
rs1409413703 CA362255076	122	R>Q		No	ClinGen gnomAD
rs760301855 CA3569071	122	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3569072 rs570905420	123	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA362255087 rs1170425831	123	P>L		No	ClinGen TOPMed
rs1395381402 CA362255098	124	D>A		No	ClinGen gnomAD
CA131847528 rs889600959	124	D>E		No	ClinGen Ensembl
rs1158649246 CA362255092	124	D>N		No	ClinGen TOPMed gnomAD
rs1158649246 CA362255096	124	D>Y		No	ClinGen TOPMed gnomAD
CA3569073 rs537989395	125	P>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1322222279 CA362255124	126	R>C		No	ClinGen TOPMed gnomAD
rs761418261 CA3569074	126	R>H		No	ClinGen ExAC TOPMed gnomAD
CA362255125 rs1322222279	126	R>S		No	ClinGen TOPMed gnomAD
CA131847534 rs573108149	127	S>N		No	ClinGen Ensembl
CA3569076 rs374491360	128	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3569075 rs780495626	128	R>W		No	ClinGen ExAC gnomAD
rs758178266 CA3569077	132	P>A		No	ClinGen ExAC TOPMed gnomAD
rs758178266 CA3569078	132	P>S		No	ClinGen ExAC TOPMed gnomAD
rs758178266 CA362255201	132	P>T		No	ClinGen ExAC TOPMed gnomAD
CA362255218 rs777987739	133	V>A		No	ClinGen ExAC gnomAD
CA3569081 rs777987739	133	V>D		No	ClinGen ExAC gnomAD
CA3569080 rs371906699 COSM1066025	133	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs779362292 CA3569084	135	D>N		No	ClinGen ExAC gnomAD
CA3569085 rs746424695	136	I>L		No	ClinGen ExAC gnomAD
rs746424695 CA131847625	136	I>V		No	ClinGen ExAC gnomAD
rs780648244 CA131847629	138	S>*		No	ClinGen Ensembl
rs1249381416 CA362255303	140	M>V		No	ClinGen TOPMed gnomAD
CA3569086 rs201034835	141	H>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA362255339 rs1418847753	142	S>A		No	ClinGen gnomAD
rs376749446 CA3569088	143	F>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA362255391 rs1161549039	145	E>G		No	ClinGen gnomAD
rs768132377 CA3569089	147	Y>H		No	ClinGen ExAC gnomAD
CA362255483 rs1411047163	151	H>Q		No	ClinGen gnomAD
CA362255499 rs1309693028	153	V>I		No	ClinGen TOPMed
CA131847667 rs989727660	154	F>L		No	ClinGen Ensembl
CA3569090 rs776443458	158	T>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	158	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362255612 rs1293600993	160	S>I		No	ClinGen gnomAD
CA3569108 rs747848226	162	A>V		No	ClinGen ExAC gnomAD
rs769428480 CA362255821	165	D>N		No	ClinGen ExAC gnomAD
rs769428480 CA3569109	165	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	166	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3569110 rs772785870	166	A>T		No	ClinGen ExAC TOPMed gnomAD
rs370200300 CA3569112	171	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs146584253 COSM208227 CA3569113	171	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA3569115 rs767349389	173	L>F		No	ClinGen ExAC gnomAD
rs754047046 CA3569116	174	L>S		No	ClinGen ExAC gnomAD
CA362255980 rs1171705627	180	D>Y		No	ClinGen gnomAD
CA3569118 rs765448279	181	D>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	181	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757541270 CA3569117	181	D>N		No	ClinGen ExAC gnomAD
rs1483076029 CA362256049	186	D>E		No	ClinGen TOPMed
CA131849109 rs764781605	186	D>H		No	ClinGen Ensembl
CA3569120 rs758524390	190	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3569121 rs529401341	190	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3569139 rs533186330	196	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA362256259 rs1157960548	197	E>D		No	ClinGen TOPMed
COSM1436149 CA362256358 rs1487796944	205	R>G	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs765393266 CA3569140	206	M>L		No	ClinGen ExAC gnomAD
rs765393266 CA362256371	206	M>V		No	ClinGen ExAC gnomAD
TCGA novel	207	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750686615 CA362256417	208	F>L		No	ClinGen ExAC gnomAD
TCGA novel	212	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	212	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3569144 rs751992903	213	T>A		No	ClinGen ExAC gnomAD
CA3569145 rs755480159	214	N>D		No	ClinGen ExAC gnomAD
CA362256508 rs1387141071	214	N>K		No	ClinGen TOPMed
rs1347543264 CA362256516	215	K>R		No	ClinGen gnomAD
CA3569146 rs781769041	216	P>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	217	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362256575 rs1298629040	220	R>K		No	ClinGen TOPMed gnomAD
CA3569147 rs753065295	220	R>S		No	ClinGen ExAC TOPMed gnomAD
CA131850683 rs921845026	221	V>A		No	ClinGen gnomAD
rs1377122692 CA362256993	224	A>D		No	ClinGen gnomAD
CA362257006 rs573849710	226	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3569168 rs573849710	226	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	234	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362257083 rs1466537086	237	M>T		No	ClinGen TOPMed
TCGA novel	241	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3569170 rs756865348	241	R>Q		No	ClinGen ExAC gnomAD
CA131850730 rs541320714	245	V>M		No	ClinGen 1000Genomes gnomAD
CA3569172 rs745332596	248	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA131850740 rs372894255	248	R>W		No	ClinGen ESP gnomAD
rs1193855541 CA362257163	250	E>G		No	ClinGen TOPMed
rs761529678 CA3569178	257	D>E		No	ClinGen ExAC gnomAD
rs776553380 CA3569177	257	D>G		No	ClinGen ExAC gnomAD
rs911704438 CA131850763	266	M>T		No	ClinGen Ensembl
rs1227307624 CA362257269	266	M>V		No	ClinGen gnomAD
rs774749275 CA3569180	267	D>E		No	ClinGen ExAC TOPMed gnomAD
rs369170772 CA3569179	267	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs759660914 CA3569181	268	A>T		No	ClinGen ExAC TOPMed gnomAD
rs138735701 CA3569182	271	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1297481128 CA362257308	271	T>I		No	ClinGen gnomAD
rs761333742 CA3569184	273	L>M		No	ClinGen ExAC gnomAD
rs1199929603 CA362257325	274	V>A		No	ClinGen gnomAD
rs969542467 CA131850810	274	V>L		No	ClinGen TOPMed
rs764514819 CA3569185	275	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs533529925 CA131850818	275	S>T		No	ClinGen gnomAD
CA3569188 rs757583095	277	R>H		No	ClinGen ExAC TOPMed gnomAD
CA3569187 rs757583095	277	R>L		No	ClinGen ExAC TOPMed gnomAD
CA362257772 rs1450703301	282	E>K		No	ClinGen TOPMed gnomAD
rs1450703301 CA362257773	282	E>Q		No	ClinGen TOPMed gnomAD
rs1183215058 CA362257783	283	R>I		No	ClinGen gnomAD
rs765635151 CA3569210 CA3569209	284	N>K		No	ClinGen ExAC TOPMed gnomAD
CA362257817 rs1471683936	288	V>L		No	ClinGen gnomAD
CA3569211 rs758111411	291	Q>E		No	ClinGen ExAC gnomAD
CA362257881 rs1581075269	297	Y>S		No	ClinGen Ensembl
TCGA novel	300	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866757023 CA362257912	302	R>I		No	ClinGen gnomAD
rs866757023 CA131852996	302	R>K		No	ClinGen gnomAD
rs925574407 CA131853011	306	E>D		No	ClinGen TOPMed gnomAD
CA3569220 rs777778262	312	R>G		No	ClinGen ExAC gnomAD
CA3569221 rs772364209	312	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3569219 rs777778262	312	R>W		No	ClinGen ExAC gnomAD
rs750266109 CA3569223	315	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA3569222 rs780444729 COSM1066026	315	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA362258014 rs1385146386	317	R>C		No	ClinGen gnomAD
CA3569224 rs768657662	317	R>H		No	ClinGen ExAC TOPMed gnomAD
CA362258021 rs1399706948	318	K>T		No	ClinGen TOPMed
CA3569225 rs200471156	319	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755730334 CA131853052	319	R>W		No	ClinGen TOPMed gnomAD
CA362258030 rs1334374077	320	R>Q		No	ClinGen TOPMed gnomAD
rs1341787254 CA362258035	321	K>E		No	ClinGen TOPMed gnomAD
rs1341787254 CA362258033	321	K>Q		No	ClinGen TOPMed gnomAD
rs1445168511 CA362258049	323	E>K		No	ClinGen gnomAD
CA362258067 rs1314365442	325	V>L		No	ClinGen TOPMed gnomAD
CA362258084 rs1230472257	327	Q>R		No	ClinGen gnomAD
TCGA novel	333	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1209738017 CA362258132	334	R>G		No	ClinGen TOPMed
rs765978756 CA3569230	336	R>Q		No	ClinGen ExAC gnomAD
CA3569229 rs143992325	336	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA3569231 rs751214973	337	Q>H		No	ClinGen ExAC gnomAD
rs1266751651 CA362258151	337	Q>R		No	ClinGen TOPMed
CA3569250 rs767203421	345	R>K		No	ClinGen ExAC TOPMed gnomAD
CA362258239 rs922684538	347	L>S		No	ClinGen TOPMed
CA131853857 rs922684538	347	L>W		No	ClinGen TOPMed
rs752092758 CA3569251	349	C>G		No	ClinGen ExAC gnomAD
rs760022482 CA362258269	352	P>A		No	ClinGen Ensembl
CA131853895 rs760022482	352	P>S		No	ClinGen Ensembl
rs1401130351 CA362258287	355	S>T		No	ClinGen gnomAD
CA362258330 rs1282844033	361	S>G		No	ClinGen TOPMed gnomAD
TCGA novel	361	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362258359 rs1581075885	365	I>V		No	ClinGen Ensembl
CA3569254 rs753865513	367	K>R		No	ClinGen ExAC TOPMed gnomAD
CA362258416 rs1210656384	373	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1216935239 CA362258442	377	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	381	S>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3569257 rs767343185	382	Q>H		No	ClinGen ExAC gnomAD
rs756176397 CA3569281	388	H>Y		No	ClinGen ExAC gnomAD
COSM1205989 CA3569283 rs749374860	389	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA362259240 rs1426139219	393	S>C		No	ClinGen gnomAD
TCGA novel	400	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA131864594 rs1028677538	406	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA3569286 rs746180663	410	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	421	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA131864607 rs986131968	423	P>H		No	ClinGen TOPMed
COSM1205988 CA362259608 rs1275831883	425	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	427	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362259812 rs1240652014	444	D>V		No	ClinGen gnomAD
CA362259819 rs765033847	445	E>*		No	ClinGen ExAC gnomAD
CA3569293 rs765033847	445	E>K		No	ClinGen ExAC gnomAD
rs763262139 CA131864671	446	E>G		No	ClinGen Ensembl

No associated diseases with Q96CS3

2 regional properties for Q96CS3

Type	Name	Position	InterPro Accession
domain	UBX domain	357 - 440	IPR001012
domain	UAS	138 - 263	IPR006577

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Lipid droplet Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
azurophil granule lumen	The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
lipid droplet	An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
VCP-NPL4-UFD1 AAA ATPase complex	A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).

4 GO annotations of molecular function

Name	Definition
lipase binding	Binding to a lipase.
lipase inhibitor activity	Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

4 GO annotations of biological process

Name	Definition
lipid droplet organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
response to unfolded protein	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
retrograde protein transport, ER to cytosol	The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q04228	UBX2	UBX domain-containing protein 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q12229	UBX3	UBX domain-containing protein 3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q96LJ8	UBXN10	UBX domain-containing protein 10	Homo sapiens (Human)	PR
Q3TDN2	Faf2	FAS-associated factor 2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAAPEERDLT	QEQTEKLLQF	QDLTGIESMD	QCRHTLEQHN	WNIEAAVQDR	LNEQEGVPSV
70	80	90	100	110	120
FNPPPSRPLQ	VNTADHRIYS	YVVSRPQPRG	LLGWGYYLIM	LPFRFTYYTI	LDIFRFALRF
130	140	150	160	170	180
IRPDPRSRVT	DPVGDIVSFM	HSFEEKYGRA	HPVFYQGTYS	QALNDAKREL	RFLLVYLHGD
190	200	210	220	230	240
DHQDSDEFCR	NTLCAPEVIS	LINTRMLFWA	CSTNKPEGYR	VSQALRENTY	PFLAMIMLKD
250	260	270	280	290	300
RRMTVVGRLE	GLIQPDDLIN	QLTFIMDANQ	TYLVSERLER	EERNQTQVLR	QQQDEAYLAS
310	320	330	340	350	360
LRADQEKERK	KREERERKRR	KEEEVQQQKL	AEERRRQNLQ	EEKERKLECL	PPEPSPDDPE
370	380	390	400	410	420
SVKIIFKLPN	DSRVERRFHF	SQSLTVIHDF	LFSLKESPEK	FQIEANFPRR	VLPCIPSEEW
430	440
PNPPTLQEAG	LSHTEVLFVQ	DLTDE