AiPD: Autoinhibited Protein Database

Q96LJ8

Gene name	UBXN10
Protein name	UBX domain-containing protein 10
Names	UBX domain-containing protein 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:127733
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

101-179 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

101-179 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96LJ8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96LJ8-F1	Predicted				AlphaFoldDB

230 variants for Q96LJ8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs369575965 CA658936	9	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1320413327 CA338820845	9	I>V		No	ClinGen TOPMed
rs755577762 CA658937	10	A>T		No	ClinGen ExAC gnomAD
rs1483567733 CA338820862	10	A>V		No	ClinGen TOPMed gnomAD
rs767761825 CA338820877	12	P>A		No	ClinGen ExAC TOPMed gnomAD
CA658938 rs767761825	12	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1234208735 CA338820889	13	E>Q		No	ClinGen gnomAD
rs373905958 CA658939	14	C>W		No	ClinGen ESP ExAC gnomAD
CA658940 rs756872871	15	S>I		No	ClinGen ExAC gnomAD
CA18914078 rs962807625	17	V>I		No	ClinGen TOPMed
CA18914082 rs995176341	18	V>I		No	ClinGen TOPMed
rs778558498 CA658941	19	S>R		No	ClinGen ExAC gnomAD
CA658942 rs199525085	21	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338820984 rs199525085	21	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA658943 rs757906905	22	V>A		No	ClinGen ExAC gnomAD
CA338821011 rs1569949939	24	S>G		No	ClinGen Ensembl
rs1430109009 CA338821016	24	S>I		No	ClinGen gnomAD
rs746903879 CA658945	24	S>R		No	ClinGen ExAC gnomAD
CA658946 rs768685550	25	L>V		No	ClinGen ExAC gnomAD
CA658949 rs377536705	28	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA338821067 rs1226890743	28	Q>H		No	ClinGen gnomAD
CA658950 rs773586084	30	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1343346979 CA338821083	30	N>I		No	ClinGen gnomAD
rs963595668 CA18914137	33	N>S		No	ClinGen Ensembl
TCGA novel	33	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1231023159 CA338821121	34	M>L		No	ClinGen gnomAD
rs1440283910 CA338821176	39	P>T		No	ClinGen gnomAD
CA658953 rs191933932	40	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs191933932 CA658954	40	K>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1186652783 CA338821205	41	S>C		No	ClinGen TOPMed gnomAD
CA658958 rs377504408	42	A>S		No	ClinGen ESP ExAC gnomAD
CA658957 rs377504408	42	A>T		No	ClinGen ESP ExAC gnomAD
rs1025770083 CA18914174	43	K>R		No	ClinGen TOPMed gnomAD
rs1422781454 CA338821225	44	G>R		No	ClinGen TOPMed gnomAD
rs779406109 CA658962 COSM1338220	45	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA658961 rs758101357 COSM463811	45	R>W	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs200664821 CA658963	48	P>L		No	ClinGen ExAC TOPMed gnomAD
rs200664821 CA658964	48	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1366474875 CA338821288	51	Q>E		No	ClinGen TOPMed gnomAD
TCGA novel	52	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1437743461 CA338821348	54	Q>R		No	ClinGen gnomAD
rs912496162 CA18914217	55	G>D		No	ClinGen TOPMed
CA658967 rs769718388	56	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	57	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs933513540 CA18914240	58	V>L		No	ClinGen gnomAD
rs933513540 CA338821415	58	V>M		No	ClinGen gnomAD
rs1218323166 CA338821437	59	C>R		No	ClinGen gnomAD
COSM1338222 rs759257774 CA18914244	60	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA658969 rs370981958	61	H>R		No	ClinGen ESP ExAC gnomAD
rs377199781 CA18914247	61	H>Y		No	ClinGen ESP gnomAD
CA338821512 rs1247354352	62	H>R		No	ClinGen gnomAD
rs1446459371 CA338821542	64	P>S		No	ClinGen TOPMed
CA658970 rs771235590	65	S>F		No	ClinGen ExAC gnomAD
rs138280233 CA658972	66	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA658975 rs201193140	68	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1431668839 CA338821632	68	P>S		No	ClinGen gnomAD
TCGA novel	72	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA658978 rs762559352	72	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA18914288 rs1054550076	74	L>F		No	ClinGen TOPMed
CA658979 rs766082670	76	S>R		No	ClinGen ExAC gnomAD
rs1398404411 CA338821906	79	K>T		No	ClinGen TOPMed
rs1330938988 CA338821937	80	P>S		No	ClinGen gnomAD
CA338821987 rs1569950410	83	C>R		No	ClinGen Ensembl
rs368463029 CA658983	84	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA338822051 rs1226170269	86	K>R		No	ClinGen gnomAD
rs1226170269 CA338822048	86	K>T		No	ClinGen gnomAD
rs140050242 CA658984	87	S>Y		No	ClinGen ESP ExAC gnomAD
rs113163326 CA338822074	88	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA18914330 rs267598328	88	P>L		No	ClinGen Ensembl
rs113163326 CA658985	88	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1235735168 CA338822170	92	A>V		No	ClinGen TOPMed
CA338822185 rs1275606658	94	D>A		No	ClinGen TOPMed
rs756181143 CA658986	94	D>N		No	ClinGen ExAC gnomAD
rs777690432 CA658987	96	I>N		No	ClinGen ExAC TOPMed
rs1217609341 CA338822221	96	I>V		No	ClinGen gnomAD
rs1045939631 CA18914352	98	E>K		No	ClinGen TOPMed gnomAD
rs771020133 CA658989	101	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA338822287 rs1320443328	101	Q>H		No	ClinGen gnomAD
rs771020133 CA338822280	101	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA658990 rs144198755	102	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA658991 rs745868022	103	V>I		No	ClinGen ExAC TOPMed gnomAD
CA658992 rs772188021	104	P>R		No	ClinGen ExAC TOPMed gnomAD
CA18914362 rs558499361	104	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA338822373 rs1406330467	107	A>T		No	ClinGen gnomAD
CA18914371 rs111829155	109	S>P		No	ClinGen Ensembl
CA338822395 rs1305395803	109	S>Y		No	ClinGen gnomAD
rs1407655195 CA338822416	111	L>F		No	ClinGen gnomAD
rs1380352172 CA338822420	111	L>P		No	ClinGen TOPMed
rs775602550 CA658994	112	N>S		No	ClinGen ExAC TOPMed gnomAD
CA338822460 rs1163457137	114	Y>F		No	ClinGen TOPMed
rs761146499 CA658995	115	P>A		No	ClinGen ExAC TOPMed gnomAD
CA658996 rs769189710	115	P>R		No	ClinGen ExAC gnomAD
CA18914385 rs1056402681	117	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA18914396 rs898241966	119	S>F		No	ClinGen TOPMed
rs1355484067 CA338822536	123	K>E		No	ClinGen gnomAD
rs756919688 CA18914413	126	E>V		No	ClinGen gnomAD
rs1013416901 CA18914417	127	E>A		No	ClinGen Ensembl
rs765893798 CA658999	127	E>D		No	ClinGen ExAC gnomAD
rs751232997 CA659000	128	E>A		No	ClinGen ExAC gnomAD
rs1252753403 CA338822607	128	E>K	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759180889 CA659001	129	A>T		No	ClinGen ExAC gnomAD
CA338822667 rs1367950707	131	E>G		No	ClinGen gnomAD
TCGA novel	131	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA659002 rs767043788	132	T>I		No	ClinGen ExAC TOPMed gnomAD
COSM182719 CA659005 rs764158276	133	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA338822725 rs1263557142	135	K>Q		No	ClinGen TOPMed
rs753639150 CA659006	136	K>R		No	ClinGen ExAC gnomAD
CA659007 rs199677811	137	A>T		No	ClinGen ExAC TOPMed gnomAD
CA659008 rs778639100	137	A>V		No	ClinGen ExAC gnomAD
CA659009 rs746088464	138	S>T		No	ClinGen ExAC TOPMed
CA659010 rs758596691	139	S>P		No	ClinGen ExAC TOPMed gnomAD
rs780073866 CA338822822	142	L>M		No	ClinGen ExAC gnomAD
TCGA novel	144	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA659013 rs769098106	144	S>N		No	ClinGen ExAC gnomAD
rs1339837214 CA338822858	145	I>V		No	ClinGen gnomAD
rs147774058 CA659015	146	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA659014 rs371858310 COSM3385668	146	R>W	upper_aerodigestive_tract pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA659017 rs149910776	147	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs770195001 CA659016	147	A>S		No	ClinGen ExAC gnomAD
rs770195001 CA338822873	147	A>T		No	ClinGen ExAC gnomAD
CA338822881 rs149910776	147	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1185988581 CA338822905	150	Q>P		No	ClinGen gnomAD
rs1185988581 CA338822907	150	Q>R		No	ClinGen gnomAD
CA18914463 rs765029383	151	D>E		No	ClinGen ExAC TOPMed gnomAD
rs116369009 CA659020	152	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200733943 CA659021	153	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs528520138 CA659023	154	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs757199409 CA659024	155	T>I		No	ClinGen ExAC gnomAD
rs757199409 CA338822963	155	T>S		No	ClinGen ExAC gnomAD
rs765057095 CA659026	158	T>R		No	ClinGen ExAC
CA659027 rs138479642	159	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758602622 CA659029	162	D>E		No	ClinGen ExAC gnomAD
TCGA novel	162	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338823082 rs1434257755	165	A>V		No	ClinGen gnomAD
CA338823086 rs1296103830	166	R>*		No	ClinGen gnomAD
rs780274676 CA659030	166	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs747031265 CA659031	167	A>V		No	ClinGen ExAC TOPMed gnomAD
CA338823099 rs1200163556	168	C>S		No	ClinGen TOPMed
rs200510194 CA659033	170	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1187611365 COSM902742 CA338823195	176	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA659035 rs374766447	177	R>*	Variant assessed as Somatic; 0.0005087 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA659036 rs370114291	177	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA659037 rs370114291	177	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1423398534 CA338823218	179	K>R		No	ClinGen TOPMed
CA659038 rs771804047	184	S>C		No	ClinGen ExAC TOPMed gnomAD
rs771804047 CA18914513	184	S>F		No	ClinGen ExAC TOPMed gnomAD
rs775297304 CA659039	185	R>G		No	ClinGen ExAC gnomAD
CA338823290 rs1364540936	187	G>*		No	ClinGen gnomAD
CA659042 rs763681547	192	P>L		No	ClinGen ExAC gnomAD
rs760468964 CA659041	192	P>S		No	ClinGen ExAC gnomAD
CA659043 rs144941949	193	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1301217143 CA338823333	194	D>N		No	ClinGen TOPMed
rs765115521 COSM463812 CA659045	196	E>G	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs924913879 CA18914524	198	R>T		No	ClinGen TOPMed
rs766517673 CA659048	201	L>F		No	ClinGen ExAC gnomAD
rs1225569003 CA338823403	205	S>T		No	ClinGen gnomAD
rs1284028298 CA338823420	207	T>I		No	ClinGen TOPMed gnomAD
rs1284028298 CA338823418	207	T>K		No	ClinGen TOPMed gnomAD
rs1284028298 CA338823419	207	T>R		No	ClinGen TOPMed gnomAD
TCGA novel	208	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338823444 rs1328540210	211	F>V		No	ClinGen gnomAD
rs755254298 CA338823450	212	V>I		No	ClinGen ExAC gnomAD
CA659050 rs755254298	212	V>L		No	ClinGen ExAC gnomAD
CA659052 rs200479622	213	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752763316 CA659053	213	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs752763316 CA338823458	213	R>L		No	ClinGen ExAC TOPMed gnomAD
CA338823461 rs1267754509	214	H>Y		No	ClinGen TOPMed gnomAD
CA659055 COSM3385670 rs778164852	216	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs756604609 CA659054	216	R>W		No	ClinGen ExAC TOPMed gnomAD
CA338823489 rs1409189557	218	T>I		No	ClinGen gnomAD
CA338823488 rs1409189557	218	T>R		No	ClinGen gnomAD
CA18914542 rs141452583	219	D>V		No	ClinGen ESP
CA338823507 rs1263027240	221	L>W		No	ClinGen TOPMed
rs1487516298 CA338823522	222	Q>R		No	ClinGen TOPMed
rs771428159 CA659057	224	I>T		No	ClinGen ExAC gnomAD
CA338823812 rs1196380306	227	V>A		No	ClinGen TOPMed
CA338823822 rs1379467310	229	E>A		No	ClinGen TOPMed
CA659063 rs761247627	229	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA338823820 rs761247627	229	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA659066 rs769709868	230	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA659065 rs769709868	230	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA659064 rs769709868	230	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA659067 rs766152348	233	K>E		No	ClinGen ExAC gnomAD
rs77427517 CA338823855	234	T>A		No	ClinGen TOPMed
CA659068 rs201689522	234	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs77427517 CA18914567	234	T>P		No	ClinGen TOPMed
CA659070 rs767665526	235	S>F		No	ClinGen ExAC gnomAD
rs759727651 CA659069	235	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1490204673 CA338823867	236	Y>C		No	ClinGen TOPMed
rs142831657 CA659071	237	R>*		No	ClinGen 1000Genomes ESP TOPMed gnomAD
CA338823871 rs142831657	237	R>G		No	ClinGen 1000Genomes ESP TOPMed gnomAD
CA659073 rs567277729	237	R>P		No	ClinGen 1000Genomes ExAC gnomAD
CA659074 rs567277729	237	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1224274074 CA338823875	238	H>Y		No	ClinGen gnomAD
rs778277643 CA659075	240	S>N		No	ClinGen ExAC gnomAD
rs764671639 CA659076	244	M>V		No	ClinGen ExAC TOPMed gnomAD
CA338823935 rs1177218642	246	V>L		No	ClinGen gnomAD
CA659078 rs779389971	247	P>L		No	ClinGen ExAC gnomAD
rs1002250418 CA18914592	248	R>K		No	ClinGen TOPMed gnomAD
rs752207873 CA659079	248	R>W		No	ClinGen ExAC gnomAD
rs147204836 CA659080	249	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs747624382 CA659082	250	R>*		No	ClinGen ExAC TOPMed gnomAD
CA659083 rs769180595	250	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772839666 CA659085	251	F>I		No	ClinGen ExAC TOPMed
rs762858485 CA659086	251	F>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	251	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770899379 CA659087	252	S>A		No	ClinGen ExAC gnomAD
rs774096113 CA659088	253	D>H		No	ClinGen ExAC gnomAD
CA659090 rs377207677	255	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA659091 rs377207677	255	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs866059211 CA18914616	256	K>R		No	ClinGen gnomAD
CA338824017 rs761026212	260	E>G		No	ClinGen ExAC gnomAD
CA659092 rs761026212	260	E>V		No	ClinGen ExAC gnomAD
CA338824024 rs1481977160	261	C>F		No	ClinGen gnomAD
rs754009611 CA659094	261	C>R		No	ClinGen ExAC gnomAD
CA338824042 rs1182936763	264	P>S		No	ClinGen gnomAD
CA659096 rs11556959	265	H>R		No	ClinGen ExAC gnomAD
rs1166423957 CA338824081	270	G>S		No	ClinGen gnomAD
rs142528987 CA659097	271	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs954973625 CA18914659	271	I>V		No	ClinGen gnomAD
CA338824094 rs1357519727	272	S>L		No	ClinGen gnomAD
rs1017730456 CA18914662	274	E>K		No	ClinGen Ensembl
rs1385540395 CA338824128	277	E>D		No	ClinGen gnomAD
TCGA novel	277	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA18914693 rs757626931	278	G>E		No	ClinGen TOPMed
CA338824134 rs757626931	278	G>V		No	ClinGen TOPMed
TCGA novel	278	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA659101 rs747745417	279	W>*		No	ClinGen ExAC gnomAD
CA338824148 rs1237234451	280	P>L		No	ClinGen gnomAD
CA338824155 rs1363056259	281	P>W		No	ClinGen gnomAD

No associated diseases with Q96LJ8

1 regional properties for Q96LJ8

Type	Name	Position	InterPro Accession
domain	UBX domain	191 - 272	IPR001012

Functions

		Description
EC Number
Subcellular Localization	Cell projection, cilium	Recruited to cilia in a VCP-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

1 GO annotations of molecular function

Name	Definition
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

2 GO annotations of biological process

Name	Definition
cilium assembly	The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q04228	UBX2	UBX domain-containing protein 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q12229	UBX3	UBX domain-containing protein 3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q96CS3	FAF2	FAS-associated factor 2	Homo sapiens (Human)	PR

10	20	30	40	50	60
MATEAPVNIA	PPECSTVVST	AVDSLIWQPN	SLNMHMIRPK	SAKGRTRPSL	QKSQGVEVCA
70	80	90	100	110	120
HHIPSPPPAI	PYELPSSQKP	GACAPKSPNQ	GASDEIPELQ	QQVPTGASSS	LNKYPVLPSI
130	140	150	160	170	180
NRKNLEEEAV	ETVAKKASSL	QLSSIRALYQ	DETGTMKTSE	EDSRARACAV	ERKFIVRTKK
190	200	210	220	230	240
QGSSRAGNLE	EPSDQEPRLL	LAVRSPTGQR	FVRHFRPTDD	LQTIVAVAEQ	KNKTSYRHCS
250	260	270
IETMEVPRRR	FSDLTKSLQE	CRIPHKSVLG	ISLEDGEGWP