AiPD: Autoinhibited Protein Database

Gene name	Faf2 (Kiaa0887, Ubxd8)
Protein name	FAS-associated factor 2
Names	UBX domain-containing protein 8
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:76577
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

37-111 (Predicted disordered autoinhibitory region) PR

37-111 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3TDN2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389284339	36	L>M	No	EVA
rs3389280413	47	V>I	No	EVA
rs3389284314	72	N>S	No	EVA
rs3389285776	76	H>Q	No	EVA
rs3389285775	87	Q>*	No	EVA
rs3413069134	119	R>C	No	EVA
rs3389283237	121	I>L	No	EVA
rs3389241536	135	D>V	No	EVA
rs3389283304	139	F>I	No	EVA
rs3389277024	146	K>T	No	EVA
rs3389292361	147	Y>*	No	EVA
rs3389283230	162	A>T	No	EVA
rs3389286338	167	K>R	No	EVA
rs3389286381	199	I>F	No	EVA
rs3404202816	209	W>*	No	EVA
rs3389286356	209	W>R	No	EVA
rs3389285765	224	A>G	No	EVA
rs3389285746	239	K>E	No	EVA
rs3389241535	241	R>Q	No	EVA
rs3389285759	262	L>V	No	EVA
rs3389292321	282	E>K	No	EVA
rs3389295211	369	P>R	No	EVA
rs3389267969	379	H>L	No	EVA
rs3389252604	379	H>N	No	EVA
rs3389292355	394	L>F	No	EVA
rs3389213676	409	R>I	No	EVA
rs3389277084	413	P>T	No	EVA
rs3389283269	420	W>C	No	EVA
rs3389295191	426	L>V	No	EVA
rs3404208284	443	T>I	No	EVA

Type	Name	Position	InterPro Accession
domain	UBX domain	357 - 440	IPR001012
domain	UAS	138 - 263	IPR006577

		Description
EC Number
Subcellular Localization	Cytoplasm Lipid droplet Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
lipid droplet	An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
VCP-NPL4-UFD1 AAA ATPase complex	A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).

Name	Definition
lipase binding	Binding to a lipase.
lipase inhibitor activity	Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

Name	Definition
lipid droplet organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
response to unfolded protein	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
retrograde protein transport, ER to cytosol	The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q04228	UBX2	UBX domain-containing protein 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q12229	UBX3	UBX domain-containing protein 3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q96CS3	FAF2	FAS-associated factor 2	Homo sapiens (Human)	PR