Q91VH2
PR
Gene name |
Snx9 |
Protein name |
Sorting nexin-9 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66616 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q91VH2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2ENM | NMR | - | A | 1-70 | PDB |
| AF-Q91VH2-F1 | Predicted | AlphaFoldDB |
24 variants for Q91VH2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389446059 | 70 | C>Y | No | EVA | |
| rs252510989 | 109 | T>S | No | EVA | |
| rs3389424802 | 116 | P>S | No | EVA | |
| rs3389440985 | 122 | S>F | No | EVA | |
| rs3389389651 | 123 | D>H | No | EVA | |
| rs584656158 | 127 | S>T | No | EVA | |
| rs578642218 | 133 | S>G | No | EVA | |
| rs3389421803 | 286 | R>* | No | EVA | |
| rs3389432632 | 317 | G>D | No | EVA | |
| rs3413084337 | 321 | E>V | No | EVA | |
| rs3389435769 | 333 | A>P | No | EVA | |
| rs3389424738 | 334 | W>R | No | EVA | |
| rs3389429213 | 348 | E>K | No | EVA | |
| rs3389437175 | 396 | E>V | No | EVA | |
| rs3407514076 | 441 | A>GRN* | No | EVA | |
| rs3389424771 | 462 | D>V | No | EVA | |
| rs3389423519 | 465 | T>I | No | EVA | |
| rs3389389653 | 493 | N>S | No | EVA | |
| rs3389345440 | 499 | F>S | No | EVA | |
| rs3389430663 | 499 | F>V | No | EVA | |
| rs3407692399 | 506 | I>T | No | EVA | |
| rs3389432633 | 519 | E>K | No | EVA | |
| rs254040645 | 560 | I>V | No | EVA | |
| rs108635389 | 590 | S>G | No | EVA |
No associated diseases with Q91VH2
6 regional properties for Q91VH2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 1 - 62 | IPR001452 |
| domain | Phox homology | 247 - 360 | IPR001683 |
| domain | Sorting nexin protein, WASP-binding domain | 358 - 592 | IPR019497 |
| domain | SNX9, SH3 domain | 4 - 60 | IPR035558 |
| domain | Sorting nexin-9, BAR domain | 386 - 595 | IPR037425 |
| domain | Sorting nexin-9, PX domain | 250 - 375 | IPR037426 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol binding | Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| Arp2/3 complex binding | Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). |
| identical protein binding | Binding to an identical protein or proteins. |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cleavage furrow formation | Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| endosomal transport | The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lipid tube assembly | The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| plasma membrane tubulation | A membrane tubulation process occurring in a plasma membrane. |
| positive regulation of actin filament polymerization | Any process that activates or increases the frequency, rate or extent of actin polymerization. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| positive regulation of membrane protein ectodomain proteolysis | Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. |
| positive regulation of protein kinase activity | Any process that activates or increases the frequency, rate or extent of protein kinase activity. |
| protein-containing complex assembly | The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. |
| receptor-mediated endocytosis | An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96RF0 | SNX18 | Sorting nexin-18 | Homo sapiens (Human) | PR |
| Q8WV41 | SNX33 | Sorting nexin-33 | Homo sapiens (Human) | PR |
| Q9Y5X1 | SNX9 | Sorting nexin-9 | Homo sapiens (Human) | PR |
| Q91ZR2 | Snx18 | Sorting nexin-18 | Mus musculus (Mouse) | PR |
| Q28GP7 | snx33 | Sorting nexin-33 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATKARVMYD | FAAEPGNNEL | TVTEGEIITV | TNPNVGGGWL | EGKNNKGEQG | LVPTDYVEIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PNDGKDPFSC | GNSVADQAFL | DSLTASTAQT | NSSSANSNNQ | VGGGNDPWTA | WNAPKPGNWD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSDAWGSRTD | GTSAQRNSSA | NNWDTGFGHP | QAYQGPATGD | DDEWDEDWDD | PKSSSPYFKD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SEPAEAGGIQ | RGNSRAGASS | MKLPLNKFPG | FAKPGMEQYL | LAKQLAKPKE | KIAIIVGDYG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PMWVYPTSTF | DCVVADPRKG | SKMYGLKSYI | EYQLTPTNTN | RSVNHRYKHF | DWLYERLLVK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FGSAIPIPSL | PDKQVTGRFE | EEFIKMRMER | LQAWMTRMCR | HPVVSESEVF | QQFLNFRDEK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EWKTGKRKAE | KDELVGVMIF | STMEPEAPDL | DLIEIEQKCD | AVGKFTKAMD | DGVKELLTVG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QEHWKRCTGP | LPKEYQKIGK | ALQSLAAVFS | SSGYQGETDL | NDAITEAGKT | YEEIASLVAE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QPKKDLHFLM | ECNHEYKGFL | GCFPDIIGAH | KGAIEKVKES | DKLVATSKIT | PQDKQTMVKR |
| 550 | 560 | 570 | 580 | 590 | |
| VGTMSYALQA | EMNHFHSNRI | YDYNSVIRLY | LEQQVQFYET | IAEKLRQALS | RFPVM |