Q28GP7
Gene name |
snx33 (sh3px3, TEgg059f08.1) |
Protein name |
Sorting nexin-33 |
Names |
SH3 and PX domain-containing protein 3 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:549122 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28GP7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28GP7-F1 | Predicted | AlphaFoldDB |
No variants for Q28GP7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28GP7 | |||||
No associated diseases with Q28GP7
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cleavage furrow formation | Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| endosomal transport | The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. |
| endosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. |
| macropinocytosis | An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| plasma membrane tubulation | A membrane tubulation process occurring in a plasma membrane. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96RF0 | SNX18 | Sorting nexin-18 | Homo sapiens (Human) | PR |
| Q9Y5X1 | SNX9 | Sorting nexin-9 | Homo sapiens (Human) | PR |
| Q8WV41 | SNX33 | Sorting nexin-33 | Homo sapiens (Human) | PR |
| Q91ZR2 | Snx18 | Sorting nexin-18 | Mus musculus (Mouse) | PR |
| Q91VH2 | Snx9 | Sorting nexin-9 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALKARALYS | FQGENKEEIN | ILENEELHLF | SDVSLDGWLQ | GTNSRGQTGL | FPASYVEILR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRSGSVQVDY | SGHTQGYTDS | PHQGSYDDDE | EDDDDWDDWD | DGQTVVDEPS | GSNGVSRSQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QHHHHYPRPE | YTHRPRPALE | RQDSIASGKR | GSVVGRNLNR | FSSFVRSGVE | AFVLGDVPQF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGVSESHAIE | MGPKGPQWKA | NPRPFSCSVE | EPTKQTKFKG | IKSYISYRLT | PDPCNSPVYR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RYKHFDWLYN | RLLHKFTVIS | VPHLPEKQAT | GRFEEDFIQK | RKRRLVLWMD | HMTSHPVLSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YDGFQHFLSC | QDEKQWKAGK | RRAERDELVG | ASFLLTLQLP | TEHQDLQDVE | ERVDVFKAFS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKMDENVLQL | SSVVSELARK | HLGGFRKEFQ | RLGAALQGLS | HSFQLDPPYS | SEPLVGAISH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TGRTYEAVGE | MFAEQPKNDQ | FRFLDTLSLY | QGLLSNFPDI | IHLQKGAFAK | VKESQRMSDE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GRMEQDEADG | IRKRCRVVGF | ALQAEINHFH | QRRLQDFKQA | IQHYLKEQIL | FYRRVSQELE |
| KTLHMYDDL |