AiPD: Autoinhibited Protein Database

Gene name	GUX3 (PGSIP2, At1g77130, T14N5.1)
Protein name	Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 3
Names	UDP-GlcA:xylan glucuronyltransferase 3, Glycogenin-like protein 3, Plant glycogenin-like starch initiation protein 2, Protein GLUCURONIC ACID SUBSTITUTION OF XYLAN 3, AtGUX3
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G77130
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-57 (Predicted disordered autoinhibitory region) PR

1-57 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8W4A7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH05159729	34	K>R	No	1000Genomes
ENSVATH13824427	67	P>S	No	1000Genomes
tmp_1_28980783_T_C	73	T>A	No	1000Genomes
ENSVATH13824426	74	T>I	No	1000Genomes
ENSVATH13824424	97	V>L	No	1000Genomes
tmp_1_28980684_T_C	106	I>V	No	1000Genomes
ENSVATH13824423	114	N>Y	No	1000Genomes
tmp_1_28980632_G_A	123	T>M	No	1000Genomes
ENSVATH13824422	144	E>D	No	1000Genomes
ENSVATH01547588	185	C>F	No	1000Genomes
ENSVATH13824421	187	K>E	No	1000Genomes
tmp_1_28980407_A_C	198	L>W	No	1000Genomes
tmp_1_28980375_C_T	209	A>T	No	1000Genomes
ENSVATH05159719	215	H>L	No	1000Genomes
ENSVATH05159717	236	E>Q	No	1000Genomes
tmp_1_28980284_G_C	239	A>G	No	1000Genomes
ENSVATH13824412	275	D>G	No	1000Genomes
ENSVATH13824409	309	R>Q	No	1000Genomes
ENSVATH13824408	326	S>N	No	1000Genomes
tmp_1_28979805_C_T	373	S>N	No	1000Genomes
ENSVATH14487028	422	Q>L	No	1000Genomes
ENSVATH05159709	426	D>G	No	1000Genomes
ENSVATH05159708	429	N>H	No	1000Genomes
ENSVATH13824406	444	E>D	No	1000Genomes
ENSVATH05159707	446	F>Y	No	1000Genomes
ENSVATH05159706	469	E>K	No	1000Genomes
ENSVATH05159705	469	E>V	No	1000Genomes
tmp_1_28979476_G_A	483	P>S	No	1000Genomes
tmp_1_28979335_C_T	530	A>T	No	1000Genomes
tmp_1_28979284_C_T	547	A>T	No	1000Genomes
tmp_1_28979262_C_T	554	R>K	No	1000Genomes
tmp_1_28979186_G_C	579	F>L	No	1000Genomes
ENSVATH05159703	581	D>H	No	1000Genomes
ENSVATH05159702	601	S>Y	No	1000Genomes
tmp_1_28979097_G_T	609	P>Q	No	1000Genomes
tmp_1_28979070_A_G	618	L>P	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)	223 - 399	IPR002314
domain	Aminoacyl-tRNA synthetase, class II	172 - 410	IPR006195
domain	Serine-tRNA synthetase, type1, N-terminal	1 - 108	IPR015866
domain	Serine-tRNA ligase catalytic core domain	120 - 417	IPR033729

		Description
EC Number
Subcellular Localization	Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endosome	A vacuole to which materials ingested by endocytosis are delivered.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
Golgi trans cisterna	The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

Name	Definition
glucuronosyltransferase activity	Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
glycosyltransferase activity	Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
metal ion binding	Binding to a metal ion.

Name	Definition
cell wall organization	A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
plant-type secondary cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana.
xylan biosynthetic process	The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P36143	GLG1	Glycogenin-1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P47011	GLG2	Glycogenin-2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P46976	GYG1	Glycogenin-1	Homo sapiens (Human)	PR
F4JMI5	PGSIP7	Putative glucuronosyltransferase PGSIP7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8H1S1	GOLS6	Galactinol synthase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FZ37	GUX4	Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GWW4	GUX2	UDP-glucuronate:xylan alpha-glucuronosyltransferase 2	Arabidopsis thaliana (Mouse-ear cress)	PR