AiPD: Autoinhibited Protein Database

Gene name	GUX2 (PGSIP3, At4g33330/At4g33340, F17M5.90/F17M5.100)
Protein name	UDP-glucuronate:xylan alpha-glucuronosyltransferase 2
Names	UDP-GlcA:xylan glucuronyltransferase 2, Glycogenin-like protein 2, Plant glycogenin-like starch initiation protein 3, Protein GLUCURONIC ACID SUBSTITUTION OF XYLAN 2, AtGUX2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G33330
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

41-128 (Predicted disordered autoinhibitory region) PR

41-128 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8GWW4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH06817535	11	A>S	No	1000Genomes
ENSVATH06817534	15	S>A	No	1000Genomes
ENSVATH00550281	15	S>F	No	1000Genomes
ENSVATH06817532	37	F>L	No	1000Genomes
tmp_4_16062940_G_A	41	S>L	No	1000Genomes
ENSVATH00550279	72	L>F	No	1000Genomes
tmp_4_16062752_C_A	75	E>*	No	1000Genomes
tmp_4_16062751_T_A	75	E>V	No	1000Genomes
ENSVATH12367789	86	A>V	No	1000Genomes
tmp_4_16062689_T_G	96	S>R	No	1000Genomes
ENSVATH06817526	96	S>T	No	1000Genomes
ENSVATH00550278	123	N>Y	No	1000Genomes
ENSVATH12367787	136	E>K	No	1000Genomes
ENSVATH14331104	149	P>T	No	1000Genomes
ENSVATH14331103	158	T>N	No	1000Genomes
ENSVATH00550277	161	P>S	No	1000Genomes
ENSVATH00550276	167	P>R	No	1000Genomes
tmp_4_16062414_A_C	187	N>K	No	1000Genomes
tmp_4_16062400_C_T	192	G>E	No	1000Genomes
tmp_4_16062305_C_A	224	V>L	No	1000Genomes
tmp_4_16062268_A_C	236	I>S	No	1000Genomes
ENSVATH06817522	251	L>M	No	1000Genomes
ENSVATH12367785	255	E>Q	No	1000Genomes
ENSVATH00550273	262	R>K	No	1000Genomes
tmp_4_16061169_G_C	283	D>E	No	1000Genomes
ENSVATH06817497	344	T>I	No	1000Genomes
ENSVATH06817496	350	A>D	No	1000Genomes
ENSVATH06817494	357	R>C	No	1000Genomes
ENSVATH12367747	404	L>F	No	1000Genomes
ENSVATH12367747	404	L>I	No	1000Genomes
tmp_4_16060784_G_C	412	Q>E	No	1000Genomes
ENSVATH12367746	416	T>A	No	1000Genomes
ENSVATH06817490	472	V>I	No	1000Genomes
tmp_4_16060410_C_A	508	W>L	No	1000Genomes
ENSVATH12367745	551	K>N	No	1000Genomes
tmp_4_16060212_C_G	574	G>A	No	1000Genomes
tmp_4_16060180_T_C	585	T>A	No	1000Genomes
tmp_4_16060171_T_A	588	R>*	No	1000Genomes
ENSVATH12367724	591	R>H	No	1000Genomes
tmp_4_16060151_C_A	594	L>F	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Helicase-like, DEXD box c2 type	9 - 275	IPR006554
domain	ATP-dependent helicase, C-terminal	527 - 706	IPR006555
domain	RAD3-like helicase, DEAD	111 - 220	IPR010614
domain	Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type	7 - 284	IPR014013

		Description
EC Number
Subcellular Localization	Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
glucuronosyltransferase activity	Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
glucuronoxylan glucuronosyltransferase activity	Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule.
glycosyltransferase activity	Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
metal ion binding	Binding to a metal ion.

Name	Definition
cell wall organization	A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
glucuronoxylan biosynthetic process	The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues.
plant-type secondary cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana.
xylan biosynthetic process	The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P36143	GLG1	Glycogenin-1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P47011	GLG2	Glycogenin-2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P46976	GYG1	Glycogenin-1	Homo sapiens (Human)	PR
F4JMI5	PGSIP7	Putative glucuronosyltransferase PGSIP7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8H1S1	GOLS6	Galactinol synthase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8W4A7	GUX3	Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FZ37	GUX4	Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 4	Arabidopsis thaliana (Mouse-ear cress)	PR