Q8H1S1
Gene name |
GOLS6 (At4g26250, T25K17.60) |
Protein name |
Galactinol synthase 6 |
Names |
AtGolS6, GolS-6 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G26250 |
EC number |
2.4.1.123: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8H1S1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8H1S1-F1 | Predicted | AlphaFoldDB |
34 variants for Q8H1S1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00539178 | 2 | A>G | No | 1000Genomes | |
| ENSVATH00539179 | 8 | V>L | No | 1000Genomes | |
| tmp_4_13289666_A_T | 9 | E>V | No | 1000Genomes | |
| ENSVATH12237015 | 12 | I>T | No | 1000Genomes | |
| ENSVATH02925788 | 18 | V>G | No | 1000Genomes | |
| tmp_4_13289698_C_A | 20 | H>N | No | 1000Genomes | |
| tmp_4_13289806_C_T | 56 | P>S | No | 1000Genomes | |
| tmp_4_13289812_G_A | 58 | V>M | No | 1000Genomes | |
| tmp_4_13289815_G_C | 59 | V>L | No | 1000Genomes | |
| tmp_4_13289841_G_T | 67 | E>D | No | 1000Genomes | |
| tmp_4_13289854_A_T | 72 | I>F | No | 1000Genomes | |
| tmp_4_13289917_A_T | 93 | T>S | No | 1000Genomes | |
| tmp_4_13290221_G_T | 114 | E>* | No | 1000Genomes | |
| tmp_4_13290288_A_G | 136 | D>G | No | 1000Genomes | |
| ENSVATH06778395 | 155 | S>A | No | 1000Genomes | |
| ENSVATH14297922 | 156 | K>Q | No | 1000Genomes | |
| tmp_4_13290410_G_A | 177 | E>K | No | 1000Genomes | |
| tmp_4_13290445_C_T,A | 188 | N>K | No | 1000Genomes | |
| tmp_4_13290482_T_A | 201 | Y>N | No | 1000Genomes | |
| ENSVATH06778396 | 209 | Q>H | No | 1000Genomes | |
| ENSVATH06778401 | 228 | D>E | No | 1000Genomes | |
| tmp_4_13290652_A_G | 231 | K>E | No | 1000Genomes | |
| tmp_4_13290684_G_T | 241 | M>I | No | 1000Genomes | |
| ENSVATH12237023 | 246 | R>H | No | 1000Genomes | |
| tmp_4_13290863_C_T | 274 | T>I | No | 1000Genomes | |
| tmp_4_13290927_A_C | 295 | E>D | No | 1000Genomes | |
| tmp_4_13290932_C_T | 297 | S>L | No | 1000Genomes | |
| tmp_4_13290949_A_G | 303 | N>D | No | 1000Genomes | |
| ENSVATH06778405 | 307 | T>P | No | 1000Genomes | |
| ENSVATH00539185 | 314 | I>M | No | 1000Genomes | |
| ENSVATH06778406 | 317 | T>S | No | 1000Genomes | |
| ENSVATH12237024 | 319 | A>P | No | 1000Genomes | |
| ENSVATH00539186 | 329 | I>L | No | 1000Genomes | |
| ENSVATH06778407 | 334 | S>Y | No | 1000Genomes |
No associated diseases with Q8H1S1
1 regional properties for Q8H1S1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 34 - 286 | IPR017452 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.123 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). |
| inositol 3-alpha-galactosyltransferase activity | Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| galactose metabolic process | The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. |
| response to stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P36143 | GLG1 | Glycogenin-1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P47011 | GLG2 | Glycogenin-2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P46976 | GYG1 | Glycogenin-1 | Homo sapiens (Human) | PR |
| F4JMI5 | PGSIP7 | Putative glucuronosyltransferase PGSIP7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4A7 | GUX3 | Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FZ37 | GUX4 | Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GWW4 | GUX2 | UDP-glucuronate:xylan alpha-glucuronosyltransferase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQMSMTVEK | SIKADVTVSH | DRVKRAYVTF | LAGNKDYWMG | VVGLAKGLRK | VKSAYPLVVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILPDVPEEHR | QILLAQGCII | REIEPVYPPE | NKTGYSMAYY | VINYSKLRIW | EFVEYEKMIY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDGDIQVFSN | IDHLFDTPRG | YLYAVKDCFC | EISWSKTPQF | KIGYCQQCPE | KVTWPVESLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPPPVYFNAG | MLVFEPNLLT | YEDLLRVVQI | TTPTYFAEQD | FLNEYFTDIY | KPIPSTYNLV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MAMLWRHPEH | IDLDQISVIH | YCANGSKPWR | FDETEEHMDR | EDIKMLVKKW | WDIYEDSSLD |
| 310 | 320 | 330 | |||
| YKNFVETESK | LSPINATLAS | KESVGDVLIS | LAPSAA |