Q8VYK4

PR
Gene name
NFYB8 (At2g37060, T2N18.18)
Protein name
Nuclear transcription factor Y subunit B-8
Names
AtNF-YB-8
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G37060
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VYK4

Entry ID Method Resolution Chain Position Source
AF-Q8VYK4-F1 Predicted AlphaFoldDB

9 variants for Q8VYK4

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05669703 9 P>H No 1000Genomes
ENSVATH01958973 24 R>S No 1000Genomes
tmp_2_15576406_G_C 24 R>T No 1000Genomes
tmp_2_15576507_G_T 58 A>S No 1000Genomes
ENSVATH00262977 139 G>V No 1000Genomes
tmp_2_15577286_A_G 143 Q>R No 1000Genomes
tmp_2_15577454_A_G 158 N>S No 1000Genomes
tmp_2_15577634_A_G 166 M>V No 1000Genomes
ENSVATH05669719 172 T>A No 1000Genomes

No associated diseases with Q8VYK4

2 regional properties for Q8VYK4

Type Name Position InterPro Accession
conserved_site Transcription factor, NFYB/HAP3, conserved site 65 - 81 IPR003956
domain Transcription factor CBF/NF-Y/archaeal histone domain 34 - 98 IPR003958

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.

5 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32KW0 NFYB Nuclear transcription factor Y subunit beta Bos taurus (Bovine) PR
Q6RG77 NFYB Nuclear transcription factor Y subunit beta Equus caballus (Horse) PR
O23310 NFYB3 Nuclear transcription factor Y subunit B-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q67XJ2 NFYB10 Nuclear transcription factor Y subunit B-10 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAESQAKSPG GCGSHESGGD QSPRSLHVRE QDRFLPIANI SRIMKRGLPA NGKIAKDAKE
70 80 90 100 110 120
IVQECVSEFI SFVTSEASDK CQREKRKTIN GDDLLWAMAT LGFEDYMEPL KVYLMRYREM
130 140 150 160 170
EGDTKGSAKG GDPNAKKDGQ SSQNGQFSQL AHQGPYGNSQ AQQHMMVPMP GTD