AiPD: Autoinhibited Protein Database

Gene name	NFYB
Protein name	Nuclear transcription factor Y subunit beta
Names	CAAT box DNA-binding protein subunit B, Nuclear transcription factor Y subunit B, NF-YB
Species	Bos taurus (Bovine)
KEGG Pathway	bta:614382
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

3-72 (Predicted disordered autoinhibitory region) PR

3-72 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q32KW0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs477547748	35	T>N	No	EVA
rs463771738	38	S>R	No	EVA
rs443667403	41	D>A	No	EVA
rs474968554	45	T>A	No	EVA
rs461668322	45	T>K	No	EVA
rs441536152	48	S>P	No	EVA
rs472816432	56	D>V	No	EVA
rs432526380	72	I>M	No	EVA
rs476367296	74	Q>H	No	EVA
rs460113079	100	E>V	No	EVA
rs440073914	105	C>F	No	EVA
rs451201916	112	T>I	No	EVA
rs471442378	112	T>P	No	EVA
rs443967004	113	I>F	No	EVA
rs475716461	117	D>Y	No	EVA
rs455593307	118	I>F	No	EVA
rs435413558	118	I>S	No	EVA
rs454253724	122	M>I	No	EVA
rs434065227	123	S>Y	No	EVA
rs465433075	124	T>P	No	EVA
rs445196006	127	F>I	No	EVA
rs437930266	135	K>R	No	EVA
rs449481468	137	Y>*	No	EVA
rs480651622	138	L>P	No	EVA
rs446997631	139	Q>H	No	EVA
rs460687596	139	Q>P	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Transcription factor, NFYB/HAP3, conserved site	89 - 105	IPR003956
domain	Transcription factor CBF/NF-Y/archaeal histone domain	58 - 122	IPR003958

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
CCAAT-binding factor complex	A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.

Name	Definition
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Name	Definition
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6RG77	NFYB	Nuclear transcription factor Y subunit beta	Equus caballus (Horse)	PR
O23310	NFYB3	Nuclear transcription factor Y subunit B-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q67XJ2	NFYB10	Nuclear transcription factor Y subunit B-10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8VYK4	NFYB8	Nuclear transcription factor Y subunit B-8	Arabidopsis thaliana (Mouse-ear cress)	PR