O23310

PR
Gene name
NFYB3
Protein name
Nuclear transcription factor Y subunit B-3
Names
AtNF-YB-3, AtNF-YB3, Transcriptional activator HAP3C
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G14540
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O23310

Entry ID Method Resolution Chain Position Source
7CVO X-ray 260 A B/G 18-120 PDB
AF-O23310-F1 Predicted AlphaFoldDB

10 variants for O23310

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_8344684_T_C 8 S>P No 1000Genomes
tmp_4_8344695_C_G 11 H>Q No 1000Genomes
tmp_4_8344705_G_A 15 G>R No 1000Genomes
tmp_4_8344852_A_T 64 I>F No 1000Genomes
tmp_4_8345054_G_T 131 G>V No 1000Genomes
ENSVATH14190652 132 G>V No 1000Genomes
tmp_4_8345063_C_A,T 134 A>D No 1000Genomes
tmp_4_8345063_C_A,T 134 A>V No 1000Genomes
ENSVATH14190653 150 T>N No 1000Genomes
tmp_4_8345118_G_A 152 M>I No 1000Genomes

No associated diseases with O23310

2 regional properties for O23310

Type Name Position InterPro Accession
conserved_site Transcription factor, NFYB/HAP3, conserved site 56 - 72 IPR003956
domain Transcription factor CBF/NF-Y/archaeal histone domain 25 - 89 IPR003958

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytosol
  • Present in both cytoplasm and nucleus under nonstress conditions but translocates in the nucleus upon heat stress
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

4 GO annotations of biological process

Name Definition
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32KW0 NFYB Nuclear transcription factor Y subunit beta Bos taurus (Bovine) PR
Q6RG77 NFYB Nuclear transcription factor Y subunit beta Equus caballus (Horse) PR
Q67XJ2 NFYB10 Nuclear transcription factor Y subunit B-10 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VYK4 NFYB8 Nuclear transcription factor Y subunit B-8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADSDNDSGG HKDGGNASTR EQDRFLPIAN VSRIMKKALP ANAKISKDAK ETVQECVSEF
70 80 90 100 110 120
ISFITGEASD KCQREKRKTI NGDDLLWAMT TLGFEDYVEP LKVYLQKYRE VEGEKTTTAG
130 140 150 160
RQGDKEGGGG GGGAGSGSGG APMYGGGMVT TMGHQFSHHF S