Q6RG77

PR
Gene name
NFYB
Protein name
Nuclear transcription factor Y subunit beta
Names
CAAT box DNA-binding protein subunit B, Nuclear transcription factor Y subunit B, NF-YB
Species
Equus caballus (Horse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

117-191 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6RG77

Entry ID Method Resolution Chain Position Source
AF-Q6RG77-F1 Predicted AlphaFoldDB

No variants for Q6RG77

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6RG77

No associated diseases with Q6RG77

2 regional properties for Q6RG77

Type Name Position InterPro Accession
conserved_site Transcription factor, NFYB/HAP3, conserved site 89 - 105 IPR003956
domain Transcription factor CBF/NF-Y/archaeal histone domain 58 - 122 IPR003958

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.

4 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32KW0 NFYB Nuclear transcription factor Y subunit beta Bos taurus (Bovine) PR
O23310 NFYB3 Nuclear transcription factor Y subunit B-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q67XJ2 NFYB10 Nuclear transcription factor Y subunit B-10 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VYK4 NFYB8 Nuclear transcription factor Y subunit B-8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTMDGDSSTT DASQLGISAD YIGGSHYVIQ PHDDTEDSMN DHEDTNGSKE SFREQDIYLP
70 80 90 100 110 120
IANVARIMKN AIPQTGKIAK DAKECVQECV SEFISFITSE ASERCHQEKR KTINGEDILF
130 140 150 160 170 180
AMSTLGFDSY VEPLKLYLQK FREAMKGEKG IGGAVTATDG LSEELAEEAF TNQLPAGLIT
190 200
ADGQQQNVMV YTTSYHQISG VQQIQFS