Q8VE47
PR
Gene name |
Uba5 |
Protein name |
Ubiquitin-like modifier-activating enzyme 5 |
Names |
Ubiquitin-activating enzyme 5, UFM1-activating enzyme |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66663 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VE47
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VE47-F1 | Predicted | AlphaFoldDB |
16 variants for Q8VE47
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs217995710 | 14 | E>D | No | EVA | |
| rs13462660 | 25 | R>G | No | EVA | |
| rs13462660 | 25 | R>W | No | EVA | |
| rs239237812 | 26 | R>C | No | EVA | |
| rs3389054626 | 30 | D>N | No | EVA | |
| rs3389062037 | 78 | G>S | No | EVA | |
| rs3389035759 | 79 | V>D | No | EVA | |
| rs3389069165 | 81 | G>* | No | EVA | |
| rs3389069122 | 114 | L>P | No | EVA | |
| rs3389062014 | 186 | R>* | No | EVA | |
| rs37379876 | 300 | Q>H | No | EVA | |
| rs217330701 | 322 | T>M | No | EVA | |
| rs246584848 | 323 | Q>R | No | EVA | |
| rs3400646325 | 377 | T>P | No | EVA | |
| rs3389064692 | 389 | S>P | No | EVA | |
| rs38528244 | 402 | N>T | No | EVA |
No associated diseases with Q8VE47
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| UFM1 activating enzyme activity | Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond. |
| zinc ion binding | Binding to a zinc ion (Zn). |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| erythrocyte differentiation | The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. |
| megakaryocyte differentiation | The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. |
| neuromuscular process | Any process pertaining to the functions of the nervous and muscular systems of an organism. |
| protein K69-linked ufmylation | A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein. |
| protein modification by small protein conjugation | A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. |
| protein ufmylation | Covalent attachment of the ubiquitin-like protein UFM1 to another protein. |
| regulation of intracellular estrogen receptor signaling pathway | Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. |
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
| reticulophagy | The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02053 | Uba1 | Ubiquitin-like modifier-activating enzyme 1 | Mus musculus (Mouse) | PR |
| Q9Z1F9 | Uba2 | SUMO-activating enzyme subunit 2 | Mus musculus (Mouse) | PR |
| P31254 | Uba1y | Ubiquitin-like modifier-activating enzyme 1 Y | Mus musculus (Mouse) | PR |
| Q8C878 | Uba3 | NEDD8-activating enzyme E1 catalytic subunit | Mus musculus (Mouse) | PR |
| Q6K6K7 | Os02g0506500 | Ubiquitin-like modifier-activating enzyme 5 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADSVERLRQ | RVEELEQELA | RERTRRSGGD | GHCGRTRIQE | MSDEVLDSNP | YSRLMALKRM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GIVSDYKKIR | TYAVAIVGVG | GVGSVTAEML | TRCGIGKLLL | FDYDKVELAN | MNRLFFQPYQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGLSKVHAAE | HTLRNINPDV | LFEVHNYNIT | TVEHFEHFMN | RISNGGLEEG | QPVDLVLSCV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DNFEARMAIN | TACNELGQTW | MESGVSENAV | SGHIQLMIPG | ESACFACAPP | LVVASNIDEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TLKREGVCAA | SLPTTMGVVA | GILVQNVLKF | LLKFGTVSFY | LGYNAMQDFF | PTMFMKPNPQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CDDKNCRKQQ | EEYKKRAAAL | PTQEAEPQEE | AEVVHEDNEW | GIELVSEVSE | EELKNSSGPV |
| 370 | 380 | 390 | 400 | ||
| PTLPEGITVA | YTVPKKTEDS | ASEVTVEDSG | ESLEDLMARM | KNM |