Q8C878
Gene name |
Uba3 (Ube1c) |
Protein name |
NEDD8-activating enzyme E1 catalytic subunit |
Names |
NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22200 |
EC number |
6.2.1.64: Acid--thiol ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C878
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C878-F1 | Predicted | AlphaFoldDB |
6 variants for Q8C878
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388846217 | 10 | K>N | No | EVA | |
| rs3396678149 | 13 | R>G | No | EVA | |
| rs3388851685 | 131 | F>L | No | EVA | |
| rs3388812105 | 133 | N>K | No | EVA | |
| rs3388812140 | 303 | Q>R | No | EVA | |
| rs3388848173 | 381 | K>E | No | EVA |
1 associated diseases with Q8C878
Without disease ID
4 regional properties for Q8C878
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | THIF-type NAD/FAD binding fold | 66 - 365 | IPR000594 |
| domain | E2 binding | 374 - 462 | IPR014929 |
| domain | NEDD8-activating enzyme E1 catalytic subunit, N-terminal domain | 71 - 368 | IPR030468 |
| active_site | Ubiquitin-activating enzyme E1, Cys active site | 235 - 243 | IPR033127 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.2.1.64 | Acid--thiol ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| identical protein binding | Binding to an identical protein or proteins. |
| NEDD8 activating enzyme activity | Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade. |
| nuclear receptor binding | Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein-containing complex binding | Binding to a macromolecular complex. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| endomitotic cell cycle | A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| protein modification by small protein conjugation | A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. |
| protein neddylation | Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TBC4 | UBA3 | NEDD8-activating enzyme E1 catalytic subunit | Homo sapiens (Human) | PR |
| P31254 | Uba1y | Ubiquitin-like modifier-activating enzyme 1 Y | Mus musculus (Mouse) | PR |
| Q02053 | Uba1 | Ubiquitin-like modifier-activating enzyme 1 | Mus musculus (Mouse) | PR |
| Q9Z1F9 | Uba2 | SUMO-activating enzyme subunit 2 | Mus musculus (Mouse) | PR |
| Q8VE47 | Uba5 | Ubiquitin-like modifier-activating enzyme 5 | Mus musculus (Mouse) | PR |
| Q99MI7 | Uba3 | NEDD8-activating enzyme E1 catalytic subunit | Rattus norvegicus (Rat) | PR |
| Q7ZVX6 | uba3 | NEDD8-activating enzyme E1 catalytic subunit | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADGEEPEKK | RRRIEELLAE | KMAVDGGCGD | TGDWEGRWNH | VKKFLERSGP | FTHPDFEPST |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ESLQFLLDTC | KVLVIGAGGL | GCELLKNLAL | SGFRQIHVID | MDTIDVSNLN | RQFLFRPKDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GRPKAEVAAE | FLNDRVPNCN | VVPHFNKIQD | FNDTFYRQFH | IIVCGLDSII | ARRWINGMLI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLLNYEDGVL | DPSSIVPLID | GGTEGFKGNA | RVILPGMTAC | IECTLELYPP | QVNFPMCTIA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SMPRLPEHCI | EYVRMLQWPK | EQPFGDGVPL | DGDDPEHIQW | IFQKSIERAS | QYNIRGVTYR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTQGVVKRII | PAVASTNAVI | AAVCATEVFK | IATSAYIPLN | NYLVFNDVDG | LYTYTFEAER |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KENCPACSQL | PQNIQFSPSA | KLQEVLDYLT | NSASLQMKSP | AITATLEGKN | RTLYLQSVTS |
| 430 | 440 | 450 | 460 | ||
| IEERTRPNLS | KTLKELGLVD | GQELAVADVT | TPQTVLFKLH | FT |