Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8C878

Entry ID Method Resolution Chain Position Source
AF-Q8C878-F1 Predicted AlphaFoldDB

6 variants for Q8C878

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388846217 10 K>N No EVA
rs3396678149 13 R>G No EVA
rs3388851685 131 F>L No EVA
rs3388812105 133 N>K No EVA
rs3388812140 303 Q>R No EVA
rs3388848173 381 K>E No EVA

1 associated diseases with Q8C878

Without disease ID

4 regional properties for Q8C878

Type Name Position InterPro Accession
domain THIF-type NAD/FAD binding fold 66 - 365 IPR000594
domain E2 binding 374 - 462 IPR014929
domain NEDD8-activating enzyme E1 catalytic subunit, N-terminal domain 71 - 368 IPR030468
active_site Ubiquitin-activating enzyme E1, Cys active site 235 - 243 IPR033127

Functions

Description
EC Number 6.2.1.64 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
NEDD8 activating enzyme activity Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.
nuclear receptor binding Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein-containing complex binding Binding to a macromolecular complex.

6 GO annotations of biological process

Name Definition
endomitotic cell cycle A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.
protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8TBC4 UBA3 NEDD8-activating enzyme E1 catalytic subunit Homo sapiens (Human) PR
P31254 Uba1y Ubiquitin-like modifier-activating enzyme 1 Y Mus musculus (Mouse) PR
Q02053 Uba1 Ubiquitin-like modifier-activating enzyme 1 Mus musculus (Mouse) PR
Q9Z1F9 Uba2 SUMO-activating enzyme subunit 2 Mus musculus (Mouse) PR
Q8VE47 Uba5 Ubiquitin-like modifier-activating enzyme 5 Mus musculus (Mouse) PR
Q99MI7 Uba3 NEDD8-activating enzyme E1 catalytic subunit Rattus norvegicus (Rat) PR
Q7ZVX6 uba3 NEDD8-activating enzyme E1 catalytic subunit Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MADGEEPEKK RRRIEELLAE KMAVDGGCGD TGDWEGRWNH VKKFLERSGP FTHPDFEPST
70 80 90 100 110 120
ESLQFLLDTC KVLVIGAGGL GCELLKNLAL SGFRQIHVID MDTIDVSNLN RQFLFRPKDV
130 140 150 160 170 180
GRPKAEVAAE FLNDRVPNCN VVPHFNKIQD FNDTFYRQFH IIVCGLDSII ARRWINGMLI
190 200 210 220 230 240
SLLNYEDGVL DPSSIVPLID GGTEGFKGNA RVILPGMTAC IECTLELYPP QVNFPMCTIA
250 260 270 280 290 300
SMPRLPEHCI EYVRMLQWPK EQPFGDGVPL DGDDPEHIQW IFQKSIERAS QYNIRGVTYR
310 320 330 340 350 360
LTQGVVKRII PAVASTNAVI AAVCATEVFK IATSAYIPLN NYLVFNDVDG LYTYTFEAER
370 380 390 400 410 420
KENCPACSQL PQNIQFSPSA KLQEVLDYLT NSASLQMKSP AITATLEGKN RTLYLQSVTS
430 440 450 460
IEERTRPNLS KTLKELGLVD GQELAVADVT TPQTVLFKLH FT