Q7ZVX6

PR
Gene name
uba3 (ube1c, zgc:55528)
Protein name
NEDD8-activating enzyme E1 catalytic subunit
Names
NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:406776
EC number
6.2.1.64: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZVX6

Entry ID Method Resolution Chain Position Source
AF-Q7ZVX6-F1 Predicted AlphaFoldDB

No variants for Q7ZVX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZVX6

No associated diseases with Q7ZVX6

No regional properties for Q7ZVX6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q7ZVX6

Functions

Description
EC Number 6.2.1.64 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
NEDD8 activating enzyme activity Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.

2 GO annotations of biological process

Name Definition
protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.
protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8TBC4 UBA3 NEDD8-activating enzyme E1 catalytic subunit Homo sapiens (Human) PR
Q8C878 Uba3 NEDD8-activating enzyme E1 catalytic subunit Mus musculus (Mouse) PR
Q99MI7 Uba3 NEDD8-activating enzyme E1 catalytic subunit Rattus norvegicus (Rat) PR
Q7SXG4 uba2 SUMO-activating enzyme subunit 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAEGEEPEKK RRRIEELNEK MVVDGGSGDR SEWQGRWDHV RKFLERTGPF THPDFEASTE
70 80 90 100 110 120
SLQFLLDTCK ILVIGAGGLG CELLKDLALS GFRHIHVVDM DTIDVSNLNR QFLFRPKDVG
130 140 150 160 170 180
RPKAEVAADF VNDRVPGCSV VPHFKKIQDL DETFYRQFHI VVCGLDSVIA RRWMNGMLLS
190 200 210 220 230 240
LLIYEDGVLD PSSIIPLIDG GTEGFKGNAR VILPGMTACI DCTLELYPPQ INFPMCTIAS
250 260 270 280 290 300
MPRLPEHCVE YVRMLLWPKE KPFGDGVVLD GDDPKHIQWV YQKSLERAAE FNITGVTYRL
310 320 330 340 350 360
TQGVVKRIIP AVASTNAVIA AACATEVFKI ATSAYVPLNN YLVFNDVDGL YTYTFEAERK
370 380 390 400 410 420
ENCSACSQVP QDMQFTPSAK LQEVLDYLTE NASLQMKSPA ITTTLDGKNK TLYLQTVASI
430 440 450 460
EERTRPNLSK TLKELGLVDG QELAVADVTT PQTVLFKLKF IS