Q7SXG4

PR
Gene name
uba2 (sae2, sae2b, uble1b)
Protein name
SUMO-activating enzyme subunit 2
Names
Ubiquitin-like 1-activating enzyme E1B, Ubiquitin-like modifier-activating enzyme 2
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:406672
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-40 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7SXG4

Entry ID Method Resolution Chain Position Source
AF-Q7SXG4-F1 Predicted AlphaFoldDB

No variants for Q7SXG4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SXG4

No associated diseases with Q7SXG4

7 regional properties for Q7SXG4

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 420 - 656 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1078 - 1316 IPR003439-2
domain AAA+ ATPase domain 447 - 639 IPR003593-1
domain AAA+ ATPase domain 1105 - 1299 IPR003593-2
domain ABC transporter type 1, transmembrane domain 62 - 385 IPR011527-1
domain ABC transporter type 1, transmembrane domain 756 - 1043 IPR011527-2
conserved_site ABC transporter-like, conserved site 559 - 573 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
SUMO activating enzyme complex A conserved heterodimeric complex with SUMO activating enzyme activity.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
SUMO activating enzyme activity Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

2 GO annotations of biological process

Name Definition
protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.
protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 Homo sapiens (Human) PR
Q9Z1F9 Uba2 SUMO-activating enzyme subunit 2 Mus musculus (Mouse) PR
Q7ZVX6 uba3 NEDD8-activating enzyme E1 catalytic subunit Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAELVGPLRK QLADSLSSCR VLVVGAGGIG CELLKNLVLT GFKNIEVIDL DTIDVSNLNR
70 80 90 100 110 120
QFLFQKKHVG KSKAQVAKES VLRFCPSANI TAYHDSIMNP DYNVEFFRNF QLVMNALDNR
130 140 150 160 170 180
AARNHVNRMC LAADIPLIES GTAGYLGQVT VIKKGQTECY ECQPKPTQKT FPGCTIRNTP
190 200 210 220 230 240
SEPIHCIVWA KYLFNQLFGE EDADQEVSPD TADPEAAWNP ADAAARATAS DQDGDIKRVS
250 260 270 280 290 300
TKEWARSTGY DPIKLFNKVS ALSQTSPYLF KDDIMYLLTM DKLWKKRKAP LPLEWEEINQ
310 320 330 340 350 360
LGSQEQVIGS GLKDQQVLGV QGYAQLFQHS VETLRSQLKE KGDGAELVWD KDDPPAMDFV
370 380 390 400 410 420
TAASNLRMNV FSMNMKSRFD VKSMAGNIIP AIATTNAVIA GLIVLEALKI LNSDFEQCRT
430 440 450 460 470 480
IFLNKQPNPR KKLLVPCALD PPNASCYVCA SKPEVTVKLN VHKTMVQALQ DKILKEKFGM
490 500 510 520 530 540
VAPDVQIEDG KGTILISSEE GETEANNNKF LSDFGIRNGS RLQADDFLQD YTLLVNVIHS
550 560 570 580 590 600
EELEKDVEFE VVGDAPDKAP APSAPEEGKN IANGNKDSAQ PSTSSKAAVE DDDVLLVDSD
610 620 630 640
EEPSSSTMDT ESSNRKRKHH DAETDDASSK RKRLDQQPAD DDDEDIIALD