AiPD: Autoinhibited Protein Database

Gene name	Uba1y (Sby, Ube1ay, Ube1y, Ube1y1)
Protein name	Ubiquitin-like modifier-activating enzyme 1 Y
Names	Ubiquitin-activating enzyme E1, Ubiquitin-activating enzyme E1 Y
Species	Mus musculus (Mouse)
KEGG Pathway
EC number	6.2.1.45: Acid--thiol ligases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-61 (Predicted disordered autoinhibitory region) PR

1-61 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P31254-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3410012458	17	S>*	No	EVA
rs3412849130	18	S>I	No	EVA
rs3411898240	18	S>L	No	EVA
rs48064925	60	V>A	No	EVA
rs51995337	127	A>S	No	EVA
rs3412777684	132	P>L	No	EVA
rs3412610382	191	R>L	No	EVA
rs3412785610	279	T>A	No	EVA
rs3411436716	287	R>S	No	EVA
rs3412577417	338	F>C	No	EVA
rs3412849182	340	T>A	No	EVA
rs3410012550	341	Q>E	No	EVA
rs3412281750	342	H>Y	No	EVA
rs3412665474	343	S>R	No	EVA
rs51133250	355	E>D	No	EVA
rs3411436744	364	V>E	No	EVA
rs3410012460	478	I>N	No	EVA
rs3412665531	481	E>D	No	EVA
rs3412578736	487	A>T	No	EVA
rs3412578682	521	W>C	No	EVA
rs3412577379	536	R>C	No	EVA
rs3412610339	881	H>R	No	EVA

Type	Name	Position	InterPro Accession
domain	THIF-type NAD/FAD binding fold	54 - 444	IPR000594-1
domain	THIF-type NAD/FAD binding fold	450 - 945	IPR000594-2
conserved_site	Ubiquitin-activating enzyme E1, conserved site	410 - 418	IPR018074
domain	Ubiquitin-activating enzyme E1, C-terminal	922 - 1053	IPR018965
domain	Ubiquitin-activating enzyme, SCCH domain	637 - 884	IPR019572
domain	Ubiquitin-activating enzyme E1, FCCH domain	226 - 295	IPR032418
domain	Ubiquitin-activating enzyme E1, four-helix bundle	297 - 365	IPR032420
active_site	Ubiquitin-activating enzyme E1, Cys active site	629 - 637	IPR033127

		Description
EC Number	6.2.1.45	Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin activating enzyme activity	Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
protein modification by small protein conjugation	A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P22314	UBA1	Ubiquitin-like modifier-activating enzyme 1	Homo sapiens (Human)	PR
Q02053	Uba1	Ubiquitin-like modifier-activating enzyme 1	Mus musculus (Mouse)	PR
Q8VE47	Uba5	Ubiquitin-like modifier-activating enzyme 5	Mus musculus (Mouse)	PR
Q9Z1F9	Uba2	SUMO-activating enzyme subunit 2	Mus musculus (Mouse)	PR
Q8C878	Uba3	NEDD8-activating enzyme E1 catalytic subunit	Mus musculus (Mouse)	PR
Q5U300	Uba1	Ubiquitin-like modifier-activating enzyme 1	Rattus norvegicus (Rat)	PR