AiPD: Autoinhibited Protein Database

Gene name	Micu1 (Cbara1)
Protein name	Calcium uptake protein 1, mitochondrial
Names	Calcium-binding atopy-related autoantigen 1 homolog
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:216001
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

31-124 (Predicted disordered autoinhibitory region) PR

31-124 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8VCX5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs46150407	6	T>A	No	EVA
rs243494634	14	A>T	No	EVA
rs1133889889	24	S>*	No	EVA
rs217351599	27	T>A	No	EVA
rs51587057	71	E>G	No	EVA
rs260471982	75	R>K	No	EVA
rs47887789	85	R>H	No	EVA
rs3389109621	87	G>R	No	EVA
rs224945249	100	D>E	No	EVA
rs3401264454	126	P>S	No	EVA
rs3389109633	129	I>N	No	EVA
rs3389105454	189	K>Q	No	EVA
rs3389102235	194	G>S	No	EVA
rs233594451	199	S>T	No	EVA
rs3389096642	203	C>F	No	EVA
rs3389096587	206	I>M	No	EVA
rs3389094272	222	Q>R	No	EVA
rs3389100171	224	N>I	No	EVA
rs3389096586	265	R>P	No	EVA
rs3389096625	274	S>P	No	EVA
rs3389096651	326	E>V	No	EVA
rs3389074582	327	R>S	No	EVA
rs3412901640	334	L>*	No	EVA
rs258871951	416	D>N	No	EVA
rs3389094348	438	I>S	No	EVA
rs3389074531	471	W>C	No	EVA

Type	Name	Position	InterPro Accession
domain	EF-hand domain	220 - 255	IPR002048-1
domain	EF-hand domain	397 - 445	IPR002048-2
binding_site	EF-Hand 1, calcium-binding site	233 - 245	IPR018247-1
binding_site	EF-Hand 1, calcium-binding site	423 - 435	IPR018247-2

		Description
EC Number
Subcellular Localization	Mitochondrion inner membrane ; Single-pass membrane protein Mitochondrion intermembrane space	The topology is subject to debate
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
calcium channel complex	An ion channel complex through which calcium ions pass.
integral component of mitochondrial membrane	The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space	The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
uniplex complex	A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
identical protein binding	Binding to an identical protein or proteins.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.

Name	Definition
calcium import into the mitochondrion	A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
calcium ion import	The directed movement of calcium ions into a cell or organelle.
mitochondrial calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
mitochondrial calcium ion transmembrane transport	The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
positive regulation of mitochondrial calcium ion concentration	Any process that increases the concentration of calcium ions in mitochondria.
protein homooligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of cellular hyperosmotic salinity response	Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0IIL1	MICU1	Calcium uptake protein 1, mitochondrial	Bos taurus (Bovine)	PR
Q86XE3	MICU3	Calcium uptake protein 3, mitochondrial	Homo sapiens (Human)	PR
Q6P6Q9	Micu1	Calcium uptake protein 1, mitochondrial	Rattus norvegicus (Rat)	PR
B1H2N3	micu1	Calcium uptake protein 1, mitochondrial	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR