Q6P6Q9

PR
Gene name
Micu1 (Cbara1)
Protein name
Calcium uptake protein 1, mitochondrial
Names
Calcium-binding atopy-related autoantigen 1 homolog
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:365567
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

26-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P6Q9

Entry ID Method Resolution Chain Position Source
AF-Q6P6Q9-F1 Predicted AlphaFoldDB

No variants for Q6P6Q9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P6Q9

No associated diseases with Q6P6Q9

4 regional properties for Q6P6Q9

Type Name Position InterPro Accession
domain EF-hand domain 220 - 255 IPR002048-1
domain EF-hand domain 397 - 445 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 233 - 245 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 423 - 435 IPR018247-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
  • Mitochondrion intermembrane space
  • The topology is subject to debate
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
calcium channel complex An ion channel complex through which calcium ions pass.
integral component of mitochondrial membrane The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
uniplex complex A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
identical protein binding Binding to an identical protein or proteins.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

7 GO annotations of biological process

Name Definition
calcium import into the mitochondrion A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
calcium ion import The directed movement of calcium ions into a cell or organelle.
mitochondrial calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
mitochondrial calcium ion transmembrane transport The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
positive regulation of mitochondrial calcium ion concentration Any process that increases the concentration of calcium ions in mitochondria.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of cellular hyperosmotic salinity response Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0IIL1 MICU1 Calcium uptake protein 1, mitochondrial Bos taurus (Bovine) PR
Q86XE3 MICU3 Calcium uptake protein 3, mitochondrial Homo sapiens (Human) PR
Q8VCX5 Micu1 Calcium uptake protein 1, mitochondrial Mus musculus (Mouse) PR
B1H2N3 micu1 Calcium uptake protein 1, mitochondrial Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MFRLNALSAL AELAVGSRWY HGTSQPTQTK RRLMLVAFLG ASAVTASTGL LWKKAHAESP
70 80 90 100 110 120
PSVNSKKTDA GDKGKSKDTR EVSSHEGSAA DTAAEPYPEE KKKKRSGFRD RKVMEYENRI
130 140 150 160 170 180
RAYSTPDKIF RYFATLKVIN EPGETEVFMT PQDFVRSITP NEKQPEHLGL DQYIIKRFDG
190 200 210 220 230 240
KKIAQEREKF ADEGSIFYTL GECGLISFSD YIFLTTVLST PQRNFEIAFK MFDLNGDGEV
250 260 270 280 290 300
DMEEFEQVQS IIRSQTSMGM RHRDRPTTGN TLKSGLCSAL TTYFFGADLK GKLTIKNFLE
310 320 330 340 350 360
FQRKLQHDVL KLEFERHDPV DGRISERQFG GMLLAYSGVQ SKKLTAMQRQ LKKHFKDGKG
370 380 390 400 410 420
LTFQEVENFF TFLKNINDVD TALSFYHMAG ASLDKVTMQQ VARTVAKVEL SDHVCDVVFA
430 440 450 460 470
LFDCDGNGEL SNKEFVSIMK QRLMRGLEKP KDMGFTRLMQ AMWKCAQETA WDFALPK