B1H2N3

PR
Gene name
micu1 (cbara1, TGas034p18.1)
Protein name
Calcium uptake protein 1, mitochondrial
Names
Calcium-binding atopy-related autoantigen 1 homolog
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100127574
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1H2N3

Entry ID Method Resolution Chain Position Source
AF-B1H2N3-F1 Predicted AlphaFoldDB

No variants for B1H2N3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1H2N3

No associated diseases with B1H2N3

4 regional properties for B1H2N3

Type Name Position InterPro Accession
domain EF-hand domain 215 - 250 IPR002048-1
domain EF-hand domain 392 - 440 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 228 - 240 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 418 - 430 IPR018247-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
  • Mitochondrion intermembrane space
  • The topology is subject to debate
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of mitochondrial membrane The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
uniplex complex A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.

1 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).

5 GO annotations of biological process

Name Definition
calcium import into the mitochondrion A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
calcium ion import The directed movement of calcium ions into a cell or organelle.
mitochondrial calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
mitochondrial calcium ion transmembrane transport The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
positive regulation of mitochondrial calcium ion concentration Any process that increases the concentration of calcium ions in mitochondria.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0IIL1 MICU1 Calcium uptake protein 1, mitochondrial Bos taurus (Bovine) PR
Q86XE3 MICU3 Calcium uptake protein 3, mitochondrial Homo sapiens (Human) PR
Q8VCX5 Micu1 Calcium uptake protein 1, mitochondrial Mus musculus (Mouse) PR
Q6P6Q9 Micu1 Calcium uptake protein 1, mitochondrial Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MFRLRFIPAV AGLAAVSRRY HGVANHARSR RRLMMAAFVG ATAVSASAGL LWKRANAEAQ
70 80 90 100 110 120
SSVKHSMREE TSEKEKEDAD QAVESSDEDQ PQEGKKKKAR VGFRDRKVME YENRIRAYST
130 140 150 160 170 180
PDKIFRYFAT LKVIHESGES EVFMTPQDFV RSITPNEKQP ENLGLDQFII KRYDGKKISQ
190 200 210 220 230 240
EREKFADEDS IFYSLGECGL ISFSDYIFLT TVLSTPQRNF EIAFKMFDLN GDGEVDMEEF
250 260 270 280 290 300
EQVQSIIRSQ TSMGMRHRDR STTGNTLKTG FSSALTTYFF GADLKGKLTI KNFLEFQRKL
310 320 330 340 350 360
QHDVLKLEFE RHDPVDGHIT ERQFGSMLLA YSGVQSKKLT HMLKQLKKRF KDAEGLTFEE
370 380 390 400 410 420
VENFFTFLKN INDVDTALSF YHMAGASLDK VTMQQVARTV AKVELSDHVC DVVFALFDCD
430 440 450 460 470
GNGELSNKEF IAIMKQRLMR GLEKPKDMGF TRLMRAMWKC AQETAWDFAM PKQ