AiPD: Autoinhibited Protein Database

Q86XE3

Gene name	MICU3 (EFHA2)
Protein name	Calcium uptake protein 3, mitochondrial
Names	EF-hand domain-containing family member A2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:286097
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

63-139 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

63-139 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q86XE3

Entry ID	Method	Resolution	Chain	Position	Source
6AGI	X-ray	280 A	A/B	133-512	PDB
6AGJ	X-ray	300 A	A/B	133-512	PDB
AF-Q86XE3-F1	Predicted				AlphaFoldDB

484 variants for Q86XE3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA370393412 rs1296715614	2	A>G		No	ClinGen gnomAD
rs1216590907 CA370393407	2	A>T		No	ClinGen gnomAD
CA370393415 rs199831377	3	A>E		No	ClinGen ExAC gnomAD
rs199831377 CA4641798	3	A>G		No	ClinGen ExAC gnomAD
CA4641797 rs781466293	3	A>S		No	ClinGen ExAC TOPMed gnomAD
CA370393413 rs781466293	3	A>T		No	ClinGen ExAC TOPMed gnomAD
rs199831377 CA370393416	3	A>V		No	ClinGen ExAC gnomAD
rs1210156287 CA370393417	4	L>M		No	ClinGen TOPMed gnomAD
CA370393419 rs770288058	4	L>P		No	ClinGen ExAC TOPMed gnomAD
CA4641799 rs770288058	4	L>R		No	ClinGen ExAC TOPMed gnomAD
CA370393418 rs1210156287	4	L>V		No	ClinGen TOPMed gnomAD
CA370393428 rs745401676	6	R>K		No	ClinGen ExAC gnomAD
rs745401676 CA4641801	6	R>M		No	ClinGen ExAC gnomAD
CA4641803 rs775181372	6	R>S		No	ClinGen ExAC TOPMed gnomAD
CA4641802 rs745401676	6	R>T		No	ClinGen ExAC gnomAD
CA370393440 rs1479949848	8	L>F		No	ClinGen gnomAD
rs760297492 CA4641804	8	L>S		No	ClinGen ExAC TOPMed gnomAD
CA4641805 rs763938987	11	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1174010179 CA370393458	11	P>S		No	ClinGen TOPMed gnomAD
CA370393457 rs1174010179	11	P>T		No	ClinGen TOPMed gnomAD
rs776637688 CA4641806	12	P>L		No	ClinGen ExAC TOPMed gnomAD
CA4641809 rs750483107	13	R>L		No	ClinGen ExAC TOPMed gnomAD
rs750483107 CA4641810	13	R>P		No	ClinGen ExAC TOPMed gnomAD
rs761777555 CA4641808	13	R>W		No	ClinGen ExAC TOPMed gnomAD
CA370393480 rs1289744910	15	S>F		No	ClinGen TOPMed gnomAD
rs766419108 CA4641811	17	P>T		No	ClinGen ExAC gnomAD
rs751793250 CA4641812	19	C>Y		No	ClinGen ExAC gnomAD
rs1223762357 CA370393511	21	H>N		No	ClinGen gnomAD
rs755220439 CA4641813	21	H>P		No	ClinGen ExAC gnomAD
rs374933358 CA172882928	21	H>Q		No	ClinGen Ensembl
CA4641814 rs781551166	23	P>L		No	ClinGen ExAC gnomAD
rs756560810 CA4641816	24	L>F		No	ClinGen ExAC gnomAD
CA4641817 rs778280523	25	L>F		No	ClinGen ExAC TOPMed gnomAD
CA4641818 rs749829944	25	L>P		No	ClinGen ExAC gnomAD
CA370393543 rs1450605800	26	G>A		No	ClinGen TOPMed gnomAD
CA370393542 rs1450605800	26	G>E		No	ClinGen TOPMed gnomAD
rs1406760492 CA370393550	27	P>Q		No	ClinGen TOPMed
rs986186451 CA370393554	28	W>*		No	ClinGen TOPMed
CA172882999 rs986186451	28	W>L		No	ClinGen TOPMed
CA4641820 rs771593237	29	G>V		No	ClinGen ExAC TOPMed gnomAD
rs2705203 CA172883009	30	R>P		No	ClinGen Ensembl
CA370393564 rs1405883152 COSM1455810	30	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs746673506 CA4641822	33	V>M		No	ClinGen ExAC gnomAD
CA4641826 rs769814462	35	T>I		No	ClinGen ExAC TOPMed gnomAD
CA172883063 rs966272199	36	L>V		No	ClinGen gnomAD
CA172883073 rs992682130	37	G>S		No	ClinGen TOPMed gnomAD
CA172883093 rs550558198	40	G>D		No	ClinGen 1000Genomes TOPMed
rs550558198 CA370393621	40	G>V		No	ClinGen 1000Genomes TOPMed
CA4641830 rs751593608	41	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1358247719 CA370393623	41	R>W		No	ClinGen gnomAD
CA4641831 rs759742770	42	P>R		No	ClinGen ExAC TOPMed gnomAD
CA4641833 rs767653174	43	F>L		No	ClinGen ExAC gnomAD
rs1180831636 CA370393649	45	S>F		No	ClinGen gnomAD
CA370393650 rs753015967 COSM3698991	46	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA4641834 rs753015967	46	R>G		No	ClinGen ExAC gnomAD
CA370393680 rs1585123540	50	E>*		No	ClinGen Ensembl
rs375812507 CA370393693	52	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs375812507 CA4641837	52	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4641838 rs570359880	53	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs909672237 CA172883165	55	E>D		No	ClinGen TOPMed
rs1047234266 CA172883142	55	E>K		No	ClinGen TOPMed gnomAD
rs1047234266 CA172883149	55	E>Q		No	ClinGen TOPMed gnomAD
CA4641839 rs779552849	55	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1469019412 CA370393713	56	A>T		No	ClinGen TOPMed
CA172883178 rs1049404322	59	R>K		No	ClinGen TOPMed gnomAD
CA370393737 rs1049404322	59	R>M		No	ClinGen TOPMed gnomAD
rs1421363759 CA370393744	60	R>L		No	ClinGen TOPMed
rs941015734 CA172883193	61	R>L		No	ClinGen TOPMed
CA4641844 rs781023389	64	W>*		No	ClinGen ExAC TOPMed gnomAD
CA172883208 CA4641843 rs781023389	64	W>C		No	ClinGen ExAC TOPMed gnomAD
CA4641842 rs540076192	64	W>L		No	ClinGen 1000Genomes ExAC TOPMed
rs1461946616 CA370393760	64	W>R		No	ClinGen TOPMed
rs1037229859 CA370393765	65	G>R		No	ClinGen TOPMed gnomAD
CA172883210 rs1037229859	65	G>W		No	ClinGen TOPMed gnomAD
CA172883212 rs905070817	66	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA370393771 rs905070817	66	E>Q		No	ClinGen TOPMed gnomAD
CA4641845 rs769698861	67	L>V		No	ClinGen ExAC TOPMed gnomAD
CA172883227 rs1056279904	69	V>G		No	ClinGen TOPMed
CA370393791 rs1416547367	69	V>L		No	ClinGen TOPMed gnomAD
CA370393812 rs1356591854	72	A>V		No	ClinGen gnomAD
CA370393829 rs1270578746	75	G>A		No	ClinGen TOPMed gnomAD
CA370393827 rs1195055446	75	G>W		No	ClinGen gnomAD
CA370393835 rs1245333273	76	G>A		No	ClinGen TOPMed
CA370393842 rs1585124091	78	V>I		No	ClinGen Ensembl
CA172883231 rs892290241	81	V>A		No	ClinGen Ensembl
CA370393873 rs1440813567	83	Y>H		No	ClinGen TOPMed gnomAD
rs535636469 CA4641848	87	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA370393906 rs1234782646	88	D>N		No	ClinGen TOPMed gnomAD
CA370393907 rs1234782646	88	D>Y		No	ClinGen TOPMed gnomAD
rs781247725 CA370393918	89	P>L		No	ClinGen TOPMed
rs781247725 CA172883244	89	P>R		No	ClinGen TOPMed
CA370393916 rs1585124239	89	P>S		No	ClinGen Ensembl
CA370393928 rs1475190512	91	A>D		No	ClinGen gnomAD
CA370393927 rs555567883	91	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4641850 rs555567883	91	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs28539976 CA4641851	92	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	95	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA172883297 rs966239714	97	G>E		No	ClinGen gnomAD
CA370393966 rs1404527433	98	R>*		No	ClinGen gnomAD
rs966874094 CA172883314	99	P>H		No	ClinGen TOPMed gnomAD
rs966874094 CA370393974	99	P>L		No	ClinGen TOPMed gnomAD
rs1449900154 CA370393978	100	S>*		No	ClinGen gnomAD
CA172883321 rs976292433	101	K>E		No	ClinGen TOPMed gnomAD
CA172883330 rs919535030	101	K>N		No	ClinGen TOPMed gnomAD
rs925463221 CA172883340	102	S>G		No	ClinGen TOPMed gnomAD
rs1226181509 CA370393999	103	A>V		No	ClinGen TOPMed gnomAD
CA172883347 rs950882637	105	T>K		No	ClinGen TOPMed gnomAD
CA370394009 rs950882637	105	T>M		No	ClinGen TOPMed gnomAD
CA172883353 rs950882637	105	T>R		No	ClinGen TOPMed gnomAD
rs985742069 CA172883365	106	E>A		No	ClinGen TOPMed
rs912229512 CA172883367	107	P>H		No	ClinGen TOPMed
rs985011168 CA172883366	107	P>S		No	ClinGen Ensembl
CA4641853 rs557690233	108	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1433226753 CA370394035	109	D>E		No	ClinGen TOPMed gnomAD
rs1205694951 CA370394029	109	D>H		No	ClinGen TOPMed gnomAD
rs918346741 CA172883405	110	P>R		No	ClinGen TOPMed
rs545378498 CA4641854	110	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs545378498 CA370394037	110	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs865800668 CA172883418	111	P>L		No	ClinGen TOPMed gnomAD
rs200500624 CA4641855	111	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs926289022 CA370394045	112	R>C		No	ClinGen TOPMed gnomAD
CA172883447 rs926289022	112	R>S		No	ClinGen TOPMed gnomAD
CA370394057 rs1261983239	114	R>Q		No	ClinGen TOPMed
CA172883460 rs1056375512	115	G>V		No	ClinGen Ensembl
CA370394067 rs1278243718	116	M>L		No	ClinGen TOPMed
CA370394076 rs1563253020	117	L>Q		No	ClinGen Ensembl
CA172883504 rs892424669	118	P>S		No	ClinGen TOPMed gnomAD
CA370394092 rs1173844780	120	P>A		No	ClinGen gnomAD
rs1405546205 CA370394097	121	V>M		No	ClinGen TOPMed
CA172883534 rs903914752	122	A>V		No	ClinGen Ensembl
rs1422134702 CA370394108	123	A>T		No	ClinGen Ensembl
rs1007657526 CA172883538	124	A>P		No	ClinGen TOPMed
rs1007657526 CA370394114	124	A>T		No	ClinGen TOPMed
CA370394120 rs1441466450	125	K>E		No	ClinGen gnomAD
CA370394123 rs1381308782	125	K>R		No	ClinGen gnomAD
CA4641858 rs751040827	126	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1156788370 CA370394128	126	E>Q		No	ClinGen TOPMed
CA370394137 rs1368588877	127	T>K		No	ClinGen TOPMed gnomAD
CA370394138 rs1368588877	127	T>M		No	ClinGen TOPMed gnomAD
rs1025283314 CA172924581	128	V>A		No	ClinGen TOPMed gnomAD
CA370396005 rs1246036896	128	V>I		No	ClinGen gnomAD
CA370396025 rs1479956768	131	G>D		No	ClinGen TOPMed gnomAD
rs1479956768 CA370396027	131	G>V		No	ClinGen TOPMed gnomAD
rs142411600 CA4641889	132	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142411600 CA4641888	132	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4641890 rs539913797	133	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA4641891 rs765515151	134	D>G		No	ClinGen ExAC gnomAD
CA172924594 rs201988057	134	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA gnomAD
CA370396047 rs1178352566	135	I>S		No	ClinGen TOPMed
rs773630135 CA4641892	135	I>V		No	ClinGen ExAC gnomAD
TCGA novel	139	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA172924617 rs528346767	140	L>V		No	ClinGen Ensembl
CA370396091 rs1405754085 COSM181910	141	Y>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1398985165 CA370396088	141	Y>H		No	ClinGen TOPMed
rs962518330 CA172924641	144	S>F		No	ClinGen TOPMed
CA370396120 rs962518330	144	S>Y		No	ClinGen TOPMed
CA4641896 rs755652013	145	R>P		No	ClinGen ExAC TOPMed gnomAD
CA4641897 rs755652013	145	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs752211068 CA4641895	145	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM239678 CA370396157 rs1333364327	148	R>*	Variant assessed as Somatic; 0.0 impact. endometrium prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	148	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200154899 CA172924669	150	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs201654618 CA4641899	150	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA4641900 rs201654618	150	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs750233627 CA4641901	151	L>S		No	ClinGen ExAC gnomAD
rs542651228 CA4641902	153	A>P		No	ClinGen 1000Genomes ExAC gnomAD
CA4641905 rs532037829	155	I>M		No	ClinGen 1000Genomes ExAC gnomAD
rs746990587 CA4641904	155	I>V		No	ClinGen ExAC gnomAD
rs781391727 CA4641906	156	E>D		No	ClinGen ExAC TOPMed gnomAD
rs992040526 CA172924717	157	C>R		No	ClinGen TOPMed
CA849266121 rs1245640547	158	E>*		No	ClinGen TOPMed
rs748250877 CA4641907	158	E>G		No	ClinGen ExAC gnomAD
rs151288641 CA4641908	159	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1240680025 CA370396291	159	G>R		No	ClinGen TOPMed gnomAD
CA370396295 rs1240680025	159	G>W		No	ClinGen TOPMed gnomAD
CA370396301 rs1428782071	160	Q>K		No	ClinGen TOPMed
rs1344676115 CA370396309	160	Q>R		No	ClinGen TOPMed
rs773398520 CA4641909	161	L>*		No	ClinGen ExAC gnomAD
CA370396322 rs773398520	161	L>S		No	ClinGen ExAC gnomAD
CA172924752 rs981248910	162	F>L		No	ClinGen Ensembl
TCGA novel	162	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370396353 rs1446784861	164	T>S		No	ClinGen gnomAD
CA4641912 rs771460585	165	P>A		No	ClinGen ExAC gnomAD
CA4641913 rs760174468	165	P>L		No	ClinGen ExAC TOPMed gnomAD
rs771460585 CA4641911	165	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1475266365 CA370396366	166	Y>*		No	ClinGen gnomAD
CA370396364 rs1419543943	166	Y>C		No	ClinGen gnomAD
CA4641915 rs753397356	168	F>I		No	ClinGen ExAC gnomAD
CA370396401 rs1360906828	171	A>V		No	ClinGen gnomAD
rs527903891 CA172924808	172	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs527903891 CA4641916	172	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA370396411 rs764968370	173	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4641917 rs764968370	173	T>K		No	ClinGen ExAC TOPMed gnomAD
rs1183221536 CA370396413	174	T>A		No	ClinGen TOPMed
rs200905352 CA4641919	175	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1484644985 CA370396419	175	D>H		No	ClinGen TOPMed
CA370396431 rs1345467000	176	E>D		No	ClinGen gnomAD
CA4641920 rs779875407	176	E>K		No	ClinGen ExAC gnomAD
rs751485839 CA4641921	177	P>R		No	ClinGen ExAC gnomAD
CA370396886 rs1554519388	180	A>S		No	ClinGen Ensembl
CA172929749 rs867600533	180	A>V		No	ClinGen Ensembl
CA4641947 rs749515238	183	W>*		No	ClinGen ExAC gnomAD
rs1336826678 CA370396977	185	S>L		No	ClinGen TOPMed
rs1261814654 CA370397003	188	K>R		No	ClinGen gnomAD
TCGA novel	192	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770467999 CA4641974	195	L>V		No	ClinGen ExAC gnomAD
rs767335819 CA4641977	196	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4641979 rs760599266	197	E>G		No	ClinGen ExAC gnomAD
rs1322928167 CA370395658	200	P>A		No	ClinGen TOPMed
CA4641980 rs764152116	202	W>G		No	ClinGen ExAC
CA370395673 rs1554522647	202	W>L		No	ClinGen Ensembl
CA4641982 rs373857886	203	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs574837028 CA4641981	203	K>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4641983 rs537594168	205	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA370395698 rs1189801220	206	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA370395701 rs1475324747	207	K>E		No	ClinGen gnomAD
CA4641986 rs780400878	208	L>V		No	ClinGen ExAC gnomAD
COSM109721 CA4641988 rs150021056	210	R>*	liver oesophagus large_intestine endometrium skin Variant assessed as Somatic; 4.632e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs565232734 COSM1173397 CA4641989	210	R>Q	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed
rs748701997 CA4641991	211	N>K		No	ClinGen ExAC gnomAD
CA4641992 rs770410801	212	L>V		No	ClinGen ExAC TOPMed gnomAD
rs199805391 CA370395746	214	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs199805391 CA4641994	214	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA172867133 rs953602800	216	G>D		No	ClinGen gnomAD
CA370395759 rs1353708770	216	G>R		No	ClinGen TOPMed gnomAD
rs1288602778 CA370396118	217	V>M		No	ClinGen gnomAD
CA370396217 rs1340472368	224	L>F		No	ClinGen TOPMed
TCGA novel	226	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4642011 rs199871743	226	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1209779652 CA370396269	228	C>R		No	ClinGen gnomAD
rs1563346586 CA370396306	230	L>*		No	ClinGen Ensembl
CA4642039 rs769668921	234	H>L		No	ClinGen ExAC TOPMed gnomAD
rs769668921 CA370396581	234	H>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	234	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA172870757 rs200859456	234	H>Y		No	ClinGen 1000Genomes
CA4642041 rs148666305	239	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA172870783 rs866660906	240	A>T		No	ClinGen Ensembl
rs1483930814 CA370396677	242	N>T		No	ClinGen TOPMed
CA4642042 rs770911769 COSM1552237	243	M>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA172870788 rs999282260	246	T>N		No	ClinGen TOPMed
rs1220938256 CA370396753	248	G>D		No	ClinGen gnomAD
CA370396782 rs1306252152	251	M>V		No	ClinGen TOPMed gnomAD
CA370396806 rs1208795403	253	D>H		No	ClinGen gnomAD
CA370396877 rs1585411000	257	F>V		No	ClinGen Ensembl
rs1397780422 CA370396939	259	V>A		No	ClinGen TOPMed
CA370397261 rs1351011558	261	Q>*		No	ClinGen gnomAD
TCGA novel	261	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1284632926 CA370397273	262	E>D		No	ClinGen gnomAD
rs1321060985 CA370397277	263	I>L		No	ClinGen gnomAD
CA172872468 rs112253967	263	I>M		No	ClinGen Ensembl
CA4642068 rs777059323	264	F>L		No	ClinGen ExAC gnomAD
rs1248380625 CA370397283	264	F>Y		No	ClinGen gnomAD
TCGA novel	265	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762169541 CA4642070	266	K>E		No	ClinGen ExAC gnomAD
CA4642071 rs141246387	266	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs751076440 CA4642072	266	K>N		No	ClinGen ExAC gnomAD
rs1159644897 CA370397301	267	K>E		No	ClinGen gnomAD
rs199759760	268	N>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1403954297 CA370397325	270	K>E		No	ClinGen gnomAD
rs578221124 CA4642076	270	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1474915602 CA370397336	271	R>S		No	ClinGen TOPMed
rs1046694910 CA172872551	272	E>G		No	ClinGen Ensembl
CA4642078 rs752287110	277	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA370397385 rs1190249320	278	E>V		No	ClinGen TOPMed
CA4642079 rs751018914	280	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4642080 rs370647732	280	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs199936197 CA4642081	281	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1000042305 CA172872597	281	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	282	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4642082 rs144959956	282	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA370397407 rs1291996121	282	M>T		No	ClinGen gnomAD
CA4642083 rs144959956	282	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs867237206 CA172872612	283	L>P		No	ClinGen Ensembl
CA4642105 rs755116160	284	R>C		No	ClinGen ExAC gnomAD
rs781446782 CA4642106	284	R>H		No	ClinGen ExAC TOPMed gnomAD
CA370397431 rs1202298652	285	L>V		No	ClinGen Ensembl
rs1383128857 CA370397455	288	Y>C		No	ClinGen TOPMed
rs1412349887 CA370397452	288	Y>H		No	ClinGen gnomAD
CA4642107 rs577425703	290	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	290	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1486064067 CA370397473	291	H>D		No	ClinGen TOPMed gnomAD
rs773715005 CA4642109	291	H>R		No	ClinGen ExAC TOPMed gnomAD
rs886125078 CA370397483	292	S>C		No	ClinGen TOPMed gnomAD
rs886125078 CA172875933	292	S>F		No	ClinGen TOPMed gnomAD
rs1443419785 CA370397479	292	S>T		No	ClinGen TOPMed
rs886125078 CA370397482	292	S>Y		No	ClinGen TOPMed gnomAD
rs1296318896 CA370397485	293	P>A		No	ClinGen gnomAD
rs1444900666 CA370397492	294	T>A		No	ClinGen TOPMed
rs1228288595 CA370397500	295	N>S		No	ClinGen gnomAD
CA4642111 rs771583400	296	S>N		No	ClinGen ExAC gnomAD
CA4642134 rs761401227	297	V>I		No	ClinGen ExAC gnomAD
CA4642135 rs764891589	300	T>R		No	ClinGen ExAC gnomAD
CA172883951 rs985146618	300	T>S		No	ClinGen TOPMed
CA370397993 rs1326614144	301	D>V		No	ClinGen gnomAD
CA370398041 rs1376465671	306	V>I		No	ClinGen TOPMed gnomAD
rs766139081 CA4642138	310	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs892574757 CA172883997	312	D>N		No	ClinGen gnomAD
CA4642140 rs200222701	313	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4642141 rs200222701	313	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA370398140 rs1337911579	314	L>P		No	ClinGen gnomAD
CA4642143 rs756364772	314	L>V		No	ClinGen ExAC gnomAD
rs778110266 CA4642144	315	R>K		No	ClinGen ExAC TOPMed gnomAD
CA370398149 rs778110266	315	R>T		No	ClinGen ExAC TOPMed gnomAD
rs202243126 CA4642145	316	R>C		No	ClinGen 1000Genomes ExAC gnomAD
COSM145358 CA4642147 rs779213885	316	R>H	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4642146 rs202243126	316	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA4642149 rs772470650	318	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1341409491 CA370398186	319	S>I		No	ClinGen TOPMed
CA4642150 rs780632265	321	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4642152 rs747691787	325	D>E		No	ClinGen ExAC gnomAD
CA4642153 rs772831859	326	L>V		No	ClinGen ExAC TOPMed gnomAD
CA4642156 rs369698557	327	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369698557 CA4642155	327	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	328	E>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759465150 CA4642157	328	E>K		No	ClinGen ExAC gnomAD
rs201776772 CA4642194	329	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4642195 rs374645079	329	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA370398393 rs1190162442	330	A>V		No	ClinGen gnomAD
rs146521840 CA4642196	333	I>F		No	ClinGen ESP ExAC gnomAD
CA172889913 rs112454980	335	S>G		No	ClinGen Ensembl
rs746886073 CA4642198	336	L>S		No	ClinGen ExAC TOPMed gnomAD
CA4642200 rs776733635	337	V>L		No	ClinGen ExAC gnomAD
rs951154615 CA172889973	338	T>A		No	ClinGen gnomAD
CA172889974 rs982716276	339	D>G		No	ClinGen Ensembl
CA4642203 rs765410229	340	T>N		No	ClinGen ExAC gnomAD
CA4642202 rs765410229	340	T>S		No	ClinGen ExAC gnomAD
rs1189515796 CA370398458	341	T>A		No	ClinGen gnomAD
CA370398468 rs1454833613	343	L>I		No	ClinGen gnomAD
rs909813617 CA172889982	344	V>I		No	ClinGen TOPMed gnomAD
CA172889983 rs866300143	345	H>N		No	ClinGen Ensembl
rs766670510 CA4642205	346	F>L		No	ClinGen ExAC gnomAD
CA172890012 rs199588638	349	K>M		No	ClinGen 1000Genomes TOPMed gnomAD
rs751940168 CA4642208	350	K>*		No	ClinGen ExAC gnomAD
CA4642210 rs755434329	352	K>I		No	ClinGen ExAC TOPMed gnomAD
rs1441103844 CA370398531	352	K>N		No	ClinGen gnomAD
CA4642209 rs755434329	352	K>R		No	ClinGen ExAC TOPMed gnomAD
rs953765889 CA172890052	353	A>G		No	ClinGen TOPMed gnomAD
rs1263483158 CA370398533	353	A>T		No	ClinGen TOPMed
rs953765889 CA370398537	353	A>V		No	ClinGen TOPMed gnomAD
CA4642212 rs753295478	354	E>D		No	ClinGen ExAC gnomAD
CA4642213 rs778551274	355	L>F		No	ClinGen ExAC gnomAD
rs1336478515 CA370398556	356	N>K		No	ClinGen TOPMed
rs745443351 CA4642214	357	F>V		No	ClinGen ExAC gnomAD
rs779947528 CA4642216	361	Y>H		No	ClinGen ExAC gnomAD
CA4642217 rs746832652	361	Y>S		No	ClinGen ExAC gnomAD
TCGA novel	362	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768612883 CA4642218	362	R>K		No	ClinGen ExAC TOPMed gnomAD
rs551599148 COSM1455812 CA4642241	363	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1218116954 CA370398619 COSM1455812	363	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA4642242 rs374778246	365	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs769790279 CA4642243	367	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1280791196 CA370398656	368	Q>H		No	ClinGen TOPMed
CA370398662 rs1278175361	369	T>I		No	ClinGen gnomAD
rs777672936 CA4642244	371	V>I		No	ClinGen ExAC TOPMed gnomAD
CA172891266 rs1055575487	372	L>P		No	ClinGen TOPMed gnomAD
CA370398677 rs1213434414	372	L>V		No	ClinGen gnomAD
rs964742035 CA172891276	374	I>L		No	ClinGen gnomAD
CA4642245 rs749330695	374	I>T		No	ClinGen ExAC gnomAD
CA4642246 rs771044367	376	F>L		No	ClinGen ExAC gnomAD
rs1325168926 CA370398704	376	F>Y		No	ClinGen TOPMed
rs759821592 CA4642248	378	S>C		No	ClinGen ExAC gnomAD
CA4642247 rs571367838	378	S>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1432674372 CA370398721	379	Y>S		No	ClinGen gnomAD
CA370398731 rs1399223039	380	S>L		No	ClinGen TOPMed
rs1175237622 CA370398734	381	N>D		No	ClinGen gnomAD
CA4642250 rs775935983	382	G>R		No	ClinGen ExAC gnomAD
rs371257325 CA4642251	383	M>K		No	ClinGen ESP ExAC gnomAD
rs996220180 CA172891350	383	M>V		No	ClinGen TOPMed
rs764695159 CA4642252	386	I>V		No	ClinGen ExAC gnomAD
rs754436884 CA4642253	387	S>N		No	ClinGen ExAC gnomAD
CA370398790 rs1345948527	389	E>G		No	ClinGen TOPMed gnomAD
rs866963641 CA172891369	392	A>G		No	ClinGen Ensembl
CA172891377 rs769530723	393	H>Y		No	ClinGen Ensembl
rs1477765575 CA370398835	395	L>R		No	ClinGen TOPMed
rs762531405 CA4642255	397	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4642257 rs374157850	397	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4642256 rs374157850	397	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1286936671 CA370398854	399	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA370398863 rs1193232221	400	N>S		No	ClinGen gnomAD
CA370398895 rs1378914290	405	S>P		No	ClinGen gnomAD
rs780794939 CA4642259	407	F>I		No	ClinGen ExAC TOPMed gnomAD
rs780794939 CA370398907	407	F>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	408	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752565476 CA4642260	408	L>S		No	ClinGen ExAC TOPMed gnomAD
rs143132509 COSM1097444 CA4642263	412	R>C	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs774411224 COSM301255 CA4642264	412	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA370398954 rs567535872	414	S>G		No	ClinGen 1000Genomes ExAC gnomAD
rs567535872 CA4642266	414	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA370398974 rs1375713637	417	E>K		No	ClinGen TOPMed
rs775679044 CA4642268	418	E>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772359765 CA4642267	418	E>K		No	ClinGen ExAC gnomAD
rs761070942 CA4642270 CA4642269	419	K>N		No	ClinGen ExAC gnomAD
CA172901033 rs992288658	420	G>D		No	ClinGen Ensembl
rs760248542 CA4642296	420	G>R		No	ClinGen ExAC gnomAD
CA4642297 rs763818030	422	T>K		No	ClinGen ExAC gnomAD
rs371778607 CA172901039	424	D>E		No	ClinGen ESP TOPMed
rs1585562661 CA370399312	424	D>G		No	ClinGen Ensembl
rs1585562698 CA370399355	427	R>K		No	ClinGen Ensembl
CA4642299 rs757144737	427	R>S		No	ClinGen ExAC TOPMed gnomAD
rs765129609 CA4642300	429	F>S		No	ClinGen ExAC gnomAD
CA4642301 rs750378199	432	F>Y		No	ClinGen ExAC
TCGA novel	433	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370399415 rs1194599310	434	N>D		No	ClinGen gnomAD
CA370399419 rs1554539276	434	N>K		No	ClinGen Ensembl
CA4642302 rs758491843	434	N>T		No	ClinGen ExAC gnomAD
CA172901064 rs1041369945	435	N>D		No	ClinGen TOPMed
CA370399429 rs1252683583	436	L>V		No	ClinGen gnomAD
rs936156878 CA172901081	440	A>E		No	ClinGen TOPMed
rs1188760895 CA370399464	441	I>V		No	ClinGen gnomAD
rs1356016244 CA370399472	442	A>D		No	ClinGen TOPMed
TCGA novel	442	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748490146 CA4642307	444	N>I		No	ClinGen ExAC gnomAD
rs748490146 CA4642308	444	N>S		No	ClinGen ExAC gnomAD
rs1434524738 CA370399499	446	Y>F		No	ClinGen gnomAD
rs150331831 CA172901136	446	Y>N		No	ClinGen ESP
CA370399516 rs137987082	448	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4642310 rs368515926	450	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA370399531 rs1415869159	451	R>C	Variant assessed as Somatic; 9.263e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs771542307 CA4642311	451	R>H		No	ClinGen ExAC gnomAD
TCGA novel	453	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1265594232 CA370399543	453	I>V		No	ClinGen TOPMed
rs774875424 CA4642312	454	G>R		No	ClinGen ExAC gnomAD
rs760323323 CA4642313	455	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs368153367 CA4642332	456	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA370399807 rs1455009490	457	E>G		No	ClinGen gnomAD
CA4642333 rs371647973	459	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4642334 rs376559239	460	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs190057007 CA4642335	460	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs190057007 CA4642336	460	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs182707903 CA4642339	462	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs182707903 CA4642338 COSM1204987	462	V>I	Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA4642340 rs759671104	463	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA370399899 rs1585572829	464	V>A		No	ClinGen Ensembl
rs377251314 CA172903598	469	K>R		No	ClinGen ESP gnomAD
TCGA novel rs1225465073 CA370399938	470	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
CA172903601 rs868734350	471	S>L		No	ClinGen Ensembl
CA4642343 rs774331215	472	P>L		No	ClinGen ExAC TOPMed gnomAD
CA370399950 rs1450227153	472	P>T		No	ClinGen gnomAD
CA370399958 rs1194948094	473	H>P		No	ClinGen gnomAD
rs1425489177 CA370399957	473	H>Y		No	ClinGen TOPMed
rs756417776 CA4642344	475	V>G		No	ClinGen ExAC gnomAD
rs1387359775 CA370399976	476	N>Y		No	ClinGen TOPMed
rs778148766 CA4642345	477	T>A		No	ClinGen ExAC gnomAD
CA370400006 rs1563400692	480	K>R		No	ClinGen Ensembl
CA4642347 rs757679706	481	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1183608300 CA370400034	484	V>F		No	ClinGen gnomAD
CA4642348 rs779266835	486	K>R		No	ClinGen ExAC gnomAD
CA370400057 rs1162113390	487	D>G		No	ClinGen gnomAD
TCGA novel	487	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370400058 rs1162113390	487	D>V		No	ClinGen gnomAD
CA4642349 rs143438471	489	Q>E		No	ClinGen ESP ExAC gnomAD
CA370400073 rs1449301957	489	Q>P		No	ClinGen TOPMed
CA370400071 rs1449301957	489	Q>R		No	ClinGen TOPMed
CA370400085 rs1487805214	491	S>C		No	ClinGen TOPMed
CA370400086 rs1419957087	491	S>N		No	ClinGen gnomAD
COSM1097445 rs747744646 CA4642352	494	E>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA172903663 rs1039735415	494	E>D		No	ClinGen TOPMed
rs747744646 CA172903658	494	E>K		No	ClinGen ExAC TOPMed gnomAD
CA370400107 rs747744646	494	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs769356501 CA4642353	496	I>T		No	ClinGen ExAC TOPMed gnomAD
CA370400121 rs1308596629	496	I>V		No	ClinGen gnomAD
rs773024367 CA4642354	500	K>E		No	ClinGen ExAC TOPMed gnomAD
CA370400151 rs1295139725	500	K>R		No	ClinGen gnomAD
TCGA novel	501	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370400175 rs1307795188	503	L>R		No	ClinGen TOPMed
CA4642355 rs749009081	504	H>R		No	ClinGen ExAC TOPMed gnomAD
CA370400178 rs1217354532	504	H>Y		No	ClinGen TOPMed
rs998374987 CA172903683 CA370400190	506	G>R		No	ClinGen TOPMed gnomAD
CA4642358 rs573999467	508	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4642356 rs770814241	508	R>W		No	ClinGen ExAC TOPMed gnomAD
CA370400573 rs1379161056	509	G>A		No	ClinGen TOPMed
CA370400569 rs1240027792	509	G>S		No	ClinGen TOPMed gnomAD
CA370400583 rs1450885706	511	K>E		No	ClinGen gnomAD
rs377123072 CA4642384	511	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA172905887 rs201985725	512	T>I		No	ClinGen 1000Genomes TOPMed gnomAD
CA370400612 rs1452328045	515	K>T		No	ClinGen gnomAD
TCGA novel	516	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1174296667 CA370400636	518	T>I		No	ClinGen gnomAD
CA4642387 rs766844621	520	K>I		No	ClinGen ExAC gnomAD
rs1442128550 CA370400675	524	K>R		No	ClinGen TOPMed
CA4642389 rs755572210	525	K>R		No	ClinGen ExAC gnomAD
TCGA novel	526	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1369301862 CA370400695	527	L>F		No	ClinGen gnomAD
CA370400729 rs1186295801	531	R>Y		No	ClinGen TOPMed

No associated diseases with Q86XE3

3 regional properties for Q86XE3

Type	Name	Position	InterPro Accession
domain	EF-hand domain	232 - 267	IPR002048-1
domain	EF-hand domain	451 - 505	IPR002048-2
binding_site	EF-Hand 1, calcium-binding site	483 - 495	IPR018247

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
uniplex complex	A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.

1 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).

2 GO annotations of biological process

Name	Definition
calcium import into the mitochondrion	A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
mitochondrial calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0IIL1	MICU1	Calcium uptake protein 1, mitochondrial	Bos taurus (Bovine)	PR
Q8VCX5	Micu1	Calcium uptake protein 1, mitochondrial	Mus musculus (Mouse)	PR
Q6P6Q9	Micu1	Calcium uptake protein 1, mitochondrial	Rattus norvegicus (Rat)	PR
B1H2N3	micu1	Calcium uptake protein 1, mitochondrial	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MAALRRLLWP	PPRVSPPLCA	HQPLLGPWGR	PAVTTLGLPG	RPFSSREDEE	RAVAEAAWRR
70	80	90	100	110	120
RRRWGELSVA	AAAGGGLVGL	VCYQLYGDPR	AGSPATGRPS	KSAATEPEDP	PRGRGMLPIP
130	140	150	160	170	180
VAAAKETVAI	GRTDIEDLDL	YATSRERRFR	LFASIECEGQ	LFMTPYDFIL	AVTTDEPKVA
190	200	210	220	230	240
KTWKSLSKQE	LNQMLAETPP	VWKGSSKLFR	NLKEKGVISY	TEYLFLLCIL	TKPHAGFRIA
250	260	270	280	290	300
FNMFDTDGNE	MVDKKEFLVL	QEIFRKKNEK	REIKGDEEKR	AMLRLQLYGY	HSPTNSVLKT
310	320	330	340	350	360
DAEELVSRSY	WDTLRRNTSQ	ALFSDLAERA	DDITSLVTDT	TLLVHFFGKK	GKAELNFEDF
370	380	390	400	410	420
YRFMDNLQTE	VLEIEFLSYS	NGMNTISEED	FAHILLRYTN	VENTSVFLEN	VRYSIPEEKG
430	440	450	460	470	480
ITFDEFRSFF	QFLNNLEDFA	IALNMYNFAS	RSIGQDEFKR	AVYVATGLKF	SPHLVNTVFK
490	500	510	520
IFDVDKDDQL	SYKEFIGIMK	DRLHRGFRGY	KTVQKYPTFK	SCLKKELHSR